Hi, my Paper with @Aoto_Lab is Published! Very excited to share our work in which we identify ventral subiculum (a very cool but understudied region of ventral hippocampus that regulates reward and stress) as a sexually... cell.com/cell-reports/fullte… (1/4)
Sardines: Pound for pound the most nutrient dense fish on the planet
An 80/20 health food at its finest
Bless yourself in 7 ways by eating these bad boys 1-3x per week
THREAD
Our paper is out! Ventral subiculum output to NAc exhibits a D2R bias and has distinct synaptic properties from vCA1 output. Cocaine withdrawal potentiates vSUB-D2R synapses.
Emma Boxer's (@EmmaEBoxer) review article is now out in @FrontNeurosci! She covers our current understanding about the functional roles neurexins and their ligands have at inhibitory synapses.
New Research: Neurexins and their ligands at inhibitory synapses: Since the discovery of neurexins (Nrxns) as essential and evolutionarily conserved synaptic adhesion molecules, focus has largely centered on their functional… frontiersin.org/articles/10.…#Synaptic#Neuroscience
Proactive vs Reactive Aggression are driven by unique circuits.
Mounting for Sex/Mating vs Mounting for Dominance are separable too.
More here: hubermanlab.com/dr-david-and…
New Huberman Lab Podcast Out Now:
THE BIOLOGY of MATING, AGGRESSION, FEAR & OTHER MOTIVATED BEHAVIORS.
• Aggression-Mating Combo Circuits
• Mounting in Sex vs Pure Dominance
• Pro- & Anti-Anxiety Peptides
• Estrogen Drives Aggression
• Fetishes
hubermanlab.com/dr-david-and…
Faculty and student (@EmmaEBoxer) research excellence awards from @AMCPharmacology. @CUAnschutz Dean's Doctoral Mentoring Award (2022). Thanks to all current and former Aoto Lab members for their nomination and support letters for the mentoring award!
How is taste info encoded? #JNeurosci research reconstructing the synaptic circuitry of taste buds from @courtthewilson et al @taste_and_smell@CUAnschutz, find that taste cannot entirely be carried along nerve fibers dedicated to single taste qualities. jneurosci.org/lookup/DOI/10.…
Most people think of hippocampal ACh as important for memory encoding or attention, but first we confirm using GRAB-ACh many microdialysis studies showing that stressors induce ACh release in hippocampus (see published data from @TjShors and others)
TIL Cheerios changed its name from Cheery Oats Bc Quaker Oats filed for trademark infringement for the use of “oats” in the name (?)… also Sylvia Plath considered it a garbage breakfast choice
For breakfast most people eat eggs or oatmeal or cold cereal. It is called by various silly names such as “Rice Krispies” and “Cheery Oats” and it always tastes the same - like little pieces of pressed hay or sawdust. 12/20/48
Hi, my Paper with @Aoto_Lab is Published! Very excited to share our work in which we identify ventral subiculum (a very cool but understudied region of ventral hippocampus that regulates reward and stress) as a sexually... cell.com/cell-reports/fullte… (1/4)
We found that this connectivity is directed in part by the presynaptic adhesion molecule, Neurexin-3, which we reveal exhibits synapse- and sex-specific functions at vSUB PV synapses. Interesting implications for understanding the sex differences observed in addiction, (3/4)
schizophrenia, and depression, which exhibit alterations in vSUB activity in rodents and humans, and are associated with Nrxn3 mutations. Thank you to my twitterless co-authors for critical help with imaging and scRNAseq and to our reviewers. (4/4)
So excited to have this work out! Ready for more sex difference stories? Check out our new paper on eLife!
elifesciences.org/articles/6…
Big thanks to my advisor @NicolaGrissom, our awesome collaborator @BecketEbs, my colleagues
@EvanKnep and everyone in lab!