Ever wonder what’s happening at centromeres in resting cells? Our latest study, led by @xssaayman and in collab with @nussenza, demonstrates striking enrichment of DNA breaks at centromeres in quiescent human cells. Excited to share this work @MolecularCell now!
Thank Dr. Wan for an exciting talk. This week, Dr. Fumiko Esashi @EsashiLab will discuss centromere instability. Sign up and check out the 2nd half of the year schedule at cancer.columbia.edu/research…
We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports.
cell.com/cell-reports/fullte…
This study, conceived 8 years ago, was made possible by a global collab across the UK, USA, Japan and Turkey. The team efforts of Emily and Lucia, relayed by Brian, Jacob, Emoke and Ramazan @rguendogdu, and invaluable assistance from many others, brought this research to life.
Huge thanks to everyone involved and the support from the community. We will be moving to another place 🦋- follow us there (@esashilab.bsky.social) if you are curious about what is going on in the Esashi lab!
We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home…
We find interesting DNA repair mechanisms that are regulated differently in quiescent cells. Excellent work by two talented PhD students, Brian and Jacob, who have contributed equally. There is definitely a lot more to learn and we welcome any feedback you may have!
This is our contribution to the Special Issue 'Cutting Edge Perspectives in Genome Maintenance XI' @repair_dna, edited by Penny Jeggo. We thank Penny for this great opportunity!
#1 Happy to share our work “Specialized replication mechanisms maintain genome stability at human centromeres” @MolecularCell from A. Scelfo, A. Angrisani and T. Wilhelm @institut_curie@CNRS where we provide the causes of centromere fragility.
authors.elsevier.com/a/1iba6…
Happy to share our review article, discussing DNA strand breaks at centromeres🧬Are they all toxic? We explore their origins and impact across cell cycle stages and quiescence - open access⬇️
doi.org/10.1016/j.semcdb.202…
Ever wonder what’s happening at centromeres in resting cells? Our latest study, led by @xssaayman and in collab with @nussenza, demonstrates striking enrichment of DNA breaks at centromeres in quiescent human cells. Excited to share this work @MolecularCell now!
🔬Excited to share the much-requested step-by-step exo-FISH protocol, now in @STARProtocols! Led by @xssaayman, meticulously tested by Emily & Brian, and enriched through peer reviews. 📝 DNA breaks at repetitive regions🧬 Let's advance together! 🚀🚀sciencedirect.com/science/ar…
🎓🎉 Huge congratulations to Emily on successfully defending her DPhil thesis! 🙌🥳Special thanks to the brilliant examiners, Peter Thorpe (@Thorpelab) and Chris Norbury (@NorbsOx), for their insightful discussion. Well done, Emily! 🍾🥂
And another postdoc opportunity!
Join the Gromak lab and help investigate the role of R-loop biology in health and disease. More info about the group here: sites.google.com/view/gromak…
Deadline: 12th May
Advert: my.corehr.com/pls/uoxrecruit…
Please share!