Max-Planck Research Group at MPI for Multidisciplinary Science (@mpi_nat) | Autophagy initiation | Structural biochemistry | Reconstitution | Views are my own.
Joined August 2018
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6 Photos and videos
4 Aug 2025
Feedforward auto-activation: activated ATG101 subsequently quickly activates non-activated ATG101 molecules to create a positive feedforward reaction and supports the local fast assembly of a key complex in autophagy initiation.
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4 Aug 2025
Thanks to all the authors for their hard work! This work was done by @mpi_nat. We thank @CompBioPhys and Urlaub laboratory for their help, and @dfg_public and @maxplanckpress for funding. Check it out for many more surprises!
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FaesenLab retweeted
29 Jun 2025
Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics biorxiv.org/content/10.1101/… #biorxiv_biochem
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29 Jun 2025
Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics
biorxiv.org/content/10.1101/…
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23 Sep 2024
Waiting for you @StorkLab in spectacular Sorrento... I've had worse views while reading literature in preparation. #EMBOautophagy24
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12 Sep 2024
Do not forget to apply!
3 Sep 2024
PhD or postdoc position in biochemistry, biophysics & structural biology @FaesenLab! Join the project focusing on the reconstitution and structural-functional characterization of newly identified and purified macromolecular super-complexes. 👇
mpinat.mpg.de/4787445/27-24
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3 Sep 2024
Place to be for scientists studying quality control mechanisms in life processes. Impressive line-up of speakers. Thx to @HMWK_Hessen @EnableFrankfurt and @dfg_public @SFB1177.
Students and postdocs are invited to apply for selected talks👍🤗
@goetheuni #ubiquitin #autophagy
3 Sep 2024
#FCQC2025: Registration open fcqc.de/
Join us for a high-caliber line-up of talks on quality control mechanisms & networks, the interplay of autophagy & ubiquitin in health & disease, novel therapeutics using the ubiquitin system.
#proteostasis #autophagy
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FaesenLab retweeted
3 Sep 2024
PhD or postdoc position in biochemistry, biophysics & structural biology @FaesenLab! Join the project focusing on the reconstitution and structural-functional characterization of newly identified and purified macromolecular super-complexes. 👇
mpinat.mpg.de/4787445/27-24
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29 Aug 2024
Link for ad: mpinat.mpg.de/27-24?c=250103…
29 Aug 2024
We are recruiting new labmembers @mpi_nat for DFG funded projects!
#Biochemistry, #biophysics and #structuralbiology on metamorphic proteins and new autophagy initiation super-complexes. #PhDposition #Postdocposition #proteins #sciencejobs
Details: mpinat.mpg.de/4787445/27-24
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29 Aug 2024
We are recruiting new labmembers @mpi_nat for DFG funded projects!
#Biochemistry, #biophysics and #structuralbiology on metamorphic proteins and new autophagy initiation super-complexes. #PhDposition #Postdocposition #proteins #sciencejobs
Details: mpinat.mpg.de/4787445/27-24
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FaesenLab retweeted
18 Jul 2024
#PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules” – Interested in theoretical and computational #biophysics? Check out the #JobAlert & apply here ⬇️: Shares welcome! #hiring #job
mpinat.mpg.de/4588467/60-23?…
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11 Jun 2024
🤔Ever wonder why Atg8 has a C-terminal overhang that is always cleaved? Why conserve it? In this mini piece on @JMolBiol Saskia dives into these questions. Thanks to
@AutophagyAarhus
and Prof. Hofmann for the collaboration!
sciencedirect.com/science/ar…
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FaesenLab retweeted
5 Jun 2024
Model of the regulation of autophagosome biogenesis by AMPK. @BarnabaCarlo, @DavidGBroadbent, @jenscs83 et al. clarify AMPKs regulatory role in #autophagy and highlight its potential as a therapeutic target to reduce autophagy. hubs.la/Q02y6LsL0
#CellMetabolism #Cancer
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4 Jun 2024
I am excited to share updated information. FINALLY, our paper has been published in eLife! What happens in autophagosomal maturation? We revealed that autophagosomal membranes become negatively charged by PI4P enrichment during maturation. elifesciences.org/articles/9…
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4 Jun 2024
Eat less to live longer? #Autophagy degrades damaged or toxic cellular material to keep cells in good shape. We discovered how #ATG16L1 shapes phagophores. Our article was published today in @NatureSMB ! thanks to all the authors !! Check it out:
nature.com/articles/s41594-0…
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