The Journal of Cell Biology (JCB) publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress
Joined September 2009
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TMEM175 does not function as a proton-selective ion channel to prevent lysosomal over-acidification/ From Erika Riederer, Dejian Ren and colleagues: hubs.la/Q04gcWRN0
📕 In #Lysosomes 2026: hubs.la/Q04gcWTK0
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Isabella M. Gaeta, Shuangshuang Du, Sara Wickström, Valentina Greco et al. show that the epidermal stem cell layer retains its capacity for proliferation despite significant fibroblast depletion during both adult and neonatal stages in vivo. hubs.la/Q04lbZDM0
#StemCells
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Shuji Wakatsuki, Toshiyuki Araki @NCNP_PR et al. show that neurons repurpose the mitotic kinase Aurora-A for synapse formation through localized redox regulation. hubs.la/Q04ldMMB0
#CellSignaling #Neuroscience
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New #tools: Lecourieux, Bardou, Garcia, and Bousso (Institut Pasteur) present Met-Vision, an imaging and machine-learning approach enabling single-cell profiling of cellular energy #metabolism. hubs.la/Q04ld8yJ0
#CellMetabolism #Immunology
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Homocysteine disrupts lysosomal function by V-ATPase inhibition. From Yang Yang, Qianjin Kong, Chaolian Liu, Mei Yang, Chonglin Yang and colleagues: hubs.la/Q04gcR4s0
📕 In #Lysosomes 2026: hubs.la/Q04gcL_20
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Journal of Cell Biology retweeted
Mighty pleased with this one. My first paper from my postdoc at the Malhotra lab @CRGenomica. We challenge how 'bulky' cargo are organised in the ER lumen and propose a new model for their export. Big thanks to the good people at @JCellBiol for their handling of the paper!
In contrast to prevailing dogma, @afororange et al. report that procollagen 1 assembles into a liquid condensate within cells, resolving the long-standing problem of how cells accommodate and export high concentrations of these bulky molecules from the ER. hubs.la/Q04l3yPd0
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.@CytoLabKoc show PCM1 multimerization scaffolds centriolar satellite assembly & drives stepwise client recruitment. Disrupting this homeostasis impairs ciliary signaling & #mitosis. Key insights into how this membraneless organelle forms & remodels hubs.la/Q04l3fVz0
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In contrast to prevailing dogma, @afororange et al. report that procollagen 1 assembles into a liquid condensate within cells, resolving the long-standing problem of how cells accommodate and export high concentrations of these bulky molecules from the ER. hubs.la/Q04l3yPd0
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Kim, @spencerSK1 et al. describe a mechanism for lysosomes to sense and respond to acute increases in their #membrane tension by relieving hydrostatic pressure via the outward transport of major osmoticants hubs.la/Q04gcVHS0
📕 In #Lysosomes 2026: hubs.la/Q04gcTyL0
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Journal of Cell Biology retweeted
Thank you very much Nicola Diny and @JCellBiol for highlighting our work on intestinal eosinophils !🙏
Spotlight: Nicola Diny @UniklinikBonn previews a study from @petrovalab et al. (hubs.la/Q04kvJwJ0) which reveals that #eosinophils drive a developmental program for postnatal intestinal remodeling and maturation. hubs.la/Q04ks9f70
#Development
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Are you attending #GRC meeting on #Lysosomes and Endocytosis? Interested in submitting your research on the endolysosomal system to JCB? Be sure to get in touch with our Deputy Editor Andrea Marat, who will be there!
📩 Email Andrea to book a time: hubs.la/Q04gGk-W0
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See our collection of recent advances related to #lysosomes, focusing on their maintenance, regulation, and relevance to human health and biology. 👉 rupress.org/jcb/collection/6…
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This collection showcases recent advances related to #lysosomes, focusing on their maintenance, regulation, and relevance to human health and biology. Explore new research to accompany the upcoming #GRC @GordonConf meeting on Lysosomes and Endocytosis:
👉 hubs.la/Q04gG2z90
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“This recognition validates years of meticulous imaging and cell biology work uncovering a novel organelle critical for meiotic fidelity,” says Julien Dumont of being included in The Year in Cell Biology: 2025. JCB is where the world meets your research: hubs.la/Q04dbGp10
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Read An interkinetic envelope surrounds chromosomes between #meiosis I and II in #Celegans oocytes rupress.org/jcb/article/224/…
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Spotlight: Nicola Diny @UniklinikBonn previews a study from @petrovalab et al. (hubs.la/Q04kvJwJ0) which reveals that #eosinophils drive a developmental program for postnatal intestinal remodeling and maturation. hubs.la/Q04ks9f70
#Development
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Marjana Ndoci, @DeshwalSoni et al. show that #mitochondria prioritize survival over safety: when resources are low, they stop exporting Coenzyme Q to keep respiration running, at the cost of antioxidant protection. hubs.la/Q04kwgfH0
#CellMetabolism #Organelles
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Endo, Saeki, Komada et al. demonstrate that USP8 is a gatekeeper of misdirected #ubiquitin signals to prevent immune and stress responses. hubs.la/Q04gcT-P0
📕 In #Lysosomes 2026: hubs.la/Q04gcXwN0
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Hämälistö, Del Valle Batalla, @LabYuseff, and @mattilalab review how #BCells have adopted specialized ways to use endolysosomal vesicles to promote adaptive immune responses. hubs.la/Q04ghTj-0
📕 In #Lysosomes 2026: hubs.la/Q04ghMfw0
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.@Rachid_Thiam and Carpentier review seipin's role in directing lipid fate, proposing it as a multinode rheostat that manages PA, ceramide, and Ca²⁺ flux at organelle contact sites to control metabolic branchpoints. hubs.la/Q04jXmy_0
#LipidDroplets #LipidMetabolism
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