Lab of Daniel Flaherty, Ph.D. Associate Professor of Medicinal Chemistry and Molecular Pharmacology at Purdue University.
Joined August 2015
- Tweets 822
- Following 449
- Followers 516
- Likes 796
180 Photos and videos
29 Aug 2025
First author J. Med. Chem. paper released and defending your PhD on the same day?! That’s a great day @Katrina_Holly98!
Very proud of our newly minted PhD from the lab!
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29 Aug 2025
New paper out today from @Katrina_Holly98 and Prabhakara Rao Tharra on their work on development of bacterial carbonic anhydrase inhibitors against vancomycin-resistant Enterococci. They produced an analog with oral efficacy rescuing mice in a septicemic peritonitis model.
Bacterial carbonic anhydrase inhibitors with improved PK and efficacy in VRE septicemia mouse model. #JMedChem @flahertylab @DrugDiscoveryPU @Purdue_MCMP
go.acs.org/d4V
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25 Nov 2024
So proud of @Purdue_MCMP and @FlahertyLab grad student @molly_youse for successfully defending her PhD today! She did an amazing job and we are super excited for her next steps in her scientific career!
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6 Nov 2024
Very proud of @Purdue_MCMP grad student and lab member @molly_youse for being awarded the Jenkins-Knevel Award for Outstanding Graduate Research! This is the highest honor in the Purdue COP for grad research. Very well deserved!
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Flaherty Lab retweeted
Design strategy from @FlahertyLab yields improved solubility for AC1 inhibitors with in vivo efficacy in rat model for inflammatory pain. #JMedChem
go.acs.org/bu1
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Flaherty Lab retweeted
25 Oct 2024
Our postdoc position is still open! #malaria #ubiquitin #proteasome #protein degradation #UPR #artemisinin #resistance #drug resistance
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15 Oct 2024
Our newest paper led by Dr. Shri Annadka presenting modifications on the pyrimidinone scaffold to improve solubility and AC1 inhibition with a new lead molecule with efficacy in a rat model for inflammatory pain.
pubs.acs.org/doi/10.1021/acs…
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15 Oct 2024
This project in collab with Dr. Val Watts and @Purdue_MCMP grad student @tiffany_summerr has gone from hit identification to through two manuscripts. The current scaffold had solubility liabilities and we took an approach to break up the molecular planarity to improve solubility
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Flaherty Lab retweeted
New ethoxzolamide analogs from @FlahertyLab show improved PK properties and efficacy in mouse model for gonococcal infection. #JMedChem
go.acs.org/aDw
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14 Aug 2024
Our new paper from @Purdue_MCMP grad student @molly_youse is out. Molly designed new analogs of Ethoxzolamide with improved PK properties and anti-gonococcal activity leading to molecules with oral efficacy in a mouse model for N. gonorrhoeae infection.
pubs.acs.org/doi/10.1021/acs…
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20 May 2024
New paper from the lab led by @Purdue_MCMP grad student @Katrina_Holly98 in collab with Groshong lab at NIAID Rocky Mountain Laboratories. Targeting the oligopeptide transport system in B. burgdorferi.
frontiersin.org/articles/10.…
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Flaherty Lab retweeted
Covalent UCHL1 inhibitor with crystal structure and anti-metastatic properties from @FlahertyLab @WendtLab_Cancer @KesslerlabOx
Read in #JMedChem here ➡ go.acs.org/8LT
ALT abstract image from linked article
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4 Apr 2024
New paper from the lab covalently targeting UCHL1. Great collab with @WendtLab_cancer @kesslerlabox and Das Lab @ClydeDadChitta! Screening, med chem, crystallography, Ub-proteomics, cellular activity all come together to tell the story. @Purdue_MCMP
pubs.acs.org/doi/full/10.102…
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28 Feb 2024
Purdue @Purdue_MCMP grad student @molly_youse was awarded 1st Place in the Poster Competition at the 2nd Annual Antimicrobial Resistance Conference for her work in lead opt/studying small molecule properties that affect accumulation in Neisseria gonorrhoeae! Congrats!
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19 Feb 2024
I am honored to receive this title. Thank you to Chip and Jane Rutledge and to @purduepharmacy for the support!
19 Feb 2024
Chip and Jane Rutledge have a history of impactful service to Purdue. The duo shares a passion for supporting early career faculty that inspired them to endow a new professorship. Daniel Flaherty is the inaugural recipient. Full story: loom.ly/kLB-aqY #pharmacysgiantleap
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8 Nov 2023
Several Flaherty Lab and @Purdue_MCMP students were recognized at the @purduepharmacy Grad Student Research Day today. Congrats to Ryan Imhoff on the Jenkins-Knevel Award and Molly and Menna for poster awards! Thank you to the grad students in lab for all your contributions!
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4 Nov 2023
Congrats to @Purdue_MCMP and Flaherty lab grad students @molly_youse and @Katrina_Holly98 for winning best oral presentation and best poster, respectively, at the second annual Purdue University - Notre Dame Symposium! Tons of hard work paid off. Proud of these ladies.
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28 Sep 2023
Our department is hiring two positions. One in chemical biology and one in translational neuroscience. Come join a fantastic department with great colleagues!
27 Sep 2023
@Purdue_MCMP is hiring for Faculty Positions in Translational Neuroscience and Chemical Biology careers.purdue.edu/job-invit…
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Flaherty Lab retweeted
27 Sep 2023
@Purdue_MCMP is hiring for Faculty Positions in Translational Neuroscience and Chemical Biology careers.purdue.edu/job-invit…
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25 Aug 2023
New paper from my group and @nglab_malaria on the identification of covalent inhibitors against P. falciparum UCHL3. Keep an eye on this work in the future from our groups 😉 @Purdue_MCMP @DrugDiscoveryPU @UNMC_PathMicro
sciencedirect.com/science/ar…
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