📢📍The Martínez-Rivera Lab focused on (Mal)adaptive & Neurobehavioral Plasticity is opening this summer/fall at @UFNeuroscience @UFMBI. We'll be hiring at all levels, please share! Academia might not be perfect, but it gave me purpose in life. 🙌🏽 💫💎☀️🎉🐊

Excited to share our new paper out today in @NatureMetabolism! "Hyperglycosylation is a metabolic driver of Alzheimer’s disease" *We bridged spatial metabolomics (MALDI-MSI glycomics lipidomics isotopic pulse-chase tracing) directly to experimental biochemistry (genetic knockdown of glycan enzymes glucosamine supplementation in AD models) and real-world public health data (EHR analysis showing glucosamine use linked to faster MCI-to-AD progression and worse survival). **Key takeaway: The AD brain shows conserved hyperglycosylation driven by ramped-up glycan biosynthesis — not just a byproduct, but a causal driver. Reducing it helps cognition; boosting it (e.g., via glucosamine) worsens outcomes. ***We applied cutting-edge spatial tech to functional validation and clinical translation. Full open-access paper: nature.com/articles/s42255-0… Huge thanks to the incredible team, collaborators (incl. Matt Gentry, Stefan Prokop, @ji0ngbi0n , Yi Guo, @lichenbiostat, Ralph Deberardinis & others), and the patients/families who make this work possible.

Deadline fast approaching! ACNP Travel Award Applications are open for the ACNP 65th Annual Meeting: January 10-13, 2027, San Diego, California. Deadline to Submit is May 14, 2026, at 5:00 pm Central. tinyurl.com/5bzaz8va #ACNP2027 #travelawards

Our review on Renewal and Reacquisition of Substance-Associated Relapse is now available! frontiersin.org/journals/psy…

It was a full house Monday for a Lunch & Learn providing the latest info on MBI Molecular Biology Core upgrades, including new technology, services & expertise. Drs. Eduardo Candelario-Jalil & Freddyson Martínez-Rivera delved into how these resources support neuro research at UF.

On Saturday, the MBI welcomed over 30 homeschool students from across Florida for a Brain Awareness Week celebration led by @NcfSfn volunteers. Students enjoyed art projects, lab tours, Q&A sessions with researchers & bike helmet giveaways. Learn more: bit.ly/4bxvgBk

We modeled sequential antidepressant treatment in chronically stressed mice to probe the molecular basis of treatment resistance (TRD). 🧵 1/ Read my latest work here! nature.com/articles/s41386-0…

OUT NOW! Here, researchers @GylesTrevonn @ericMparise @angelica_atb, et al. provide insight into gene networks contributing to #Antidepressant non-response & highlight a mechanistic framework for modeling antidepressant resistance in preclinical systems👉nature.com/articles/s41386-0…

Congratulations to MBI researcher @DrNancyPadilla, who recently received the 2026 @UFMedicine Rising Star Researcher in Basic Science Award! Learn more about her research by watching this short video. @UFNeuroscience

Good morning, it’s #GatorNationGivingDay! For the next 24 hours, Gators everywhere are coming together to make an impact. Thanks to generous donors, gifts made to the MBI today will be matched dollar-for-dollar, up to $3,000, to support our mission: bit.ly/GNGD_MBI

Lo único más poderoso que el odio, es el amor. The Only Thing More Powerful Than Hate is Love. @sanbenito #AppleMusicHalftime

Bad Bunny closed out his #SuperBowl performance with a billboard behind him saying: “The only thing more powerful than hate is love”

Curious how astrocytes in the PFC regulate the negative effects of stress? Read our preprint on Biorxiv now: biorxiv.org/content/10.64898… So excited to start my astrocyte journey with @holtlm90 & @EricJNestler!! 🧠 PS: hear all about it at Winter Brain this Sunday (5-7pm).

Really excited to announce that the Holt lab will be starting in January 2026 @CSARtemplemed @katztemplemed! Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions! DM or email me! l-holt-lab.com/

Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/4140…

Please see this new publication by Leanne Holt and colleagues in @ScienceAdv that defines a role for CREB, acting within astrocytes of the nucleus accumbens, to control the activity of medium spiny neurons and consequently behavioral responses to cocaine. pubmed.ncbi.nlm.nih.gov/4140…

(1/6) We have a new paper out in #eNeuro! How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆 Read more: eneuro.org/content/12/11/ENE…

Thank you for sharing our review!!

Dopamine doesn’t just drive reward; it guides our social lives. This review explores how dopamine regulates social behaviour across species. #PharmRev #Dopamine @DrNancyPadilla @FreddysonJ ow.ly/hx0x50XARUX

Memorias del PR Social! Gracias por el apoyo!🇵🇷

Boricua marca tu calendario SfN PR social! Cc: @albit_caban Aranza Torrado @CBravoRivera,