Excited to share our new paper out today in @NatureMetabolism! "Hyperglycosylation is a metabolic driver of Alzheimer’s disease" *We bridged spatial metabolomics (MALDI-MSI glycomics lipidomics isotopic pulse-chase tracing) directly to experimental biochemistry (genetic knockdown of glycan enzymes glucosamine supplementation in AD models) and real-world public health data (EHR analysis showing glucosamine use linked to faster MCI-to-AD progression and worse survival). **Key takeaway: The AD brain shows conserved hyperglycosylation driven by ramped-up glycan biosynthesis — not just a byproduct, but a causal driver. Reducing it helps cognition; boosting it (e.g., via glucosamine) worsens outcomes. ***We applied cutting-edge spatial tech to functional validation and clinical translation. Full open-access paper: nature.com/articles/s42255-0… Huge thanks to the incredible team, collaborators (incl. Matt Gentry, Stefan Prokop, @ji0ngbi0n , Yi Guo, @lichenbiostat, Ralph Deberardinis & others), and the patients/families who make this work possible.

Great piece by @UFMBI way to go Elias !!

Congratulations to MBI researcher Dr. Elias Sayour, who was one of three scientists worldwide honored this week at the 2026 BioInnovation Institute & Science Prize for Innovation ceremony in Copenhagen. Learn more: bit.ly/4dLGhAI

Funniest post I seen all week ! We should all stop posting depressing shit and make this the future of academic X. Lol…

New paper on this coming out very soon, stay tuned !

this is so fucking wholesome guy used AI to save his cancer-ridden dog by sequencing its DNA and creating a CUSTOM cure. the tech behind this is fucking awesome (well done @demishassabis and the google team): - used CHATGPT to sequence dogs DNA discovers mutations - ran the mutations through Google’s Alphafold (AI protein sequencer) which CREATED A CUSTOM VACCINE TO TREAT THEM. - treated dog and reduced tumour by 50% in WEEKS. dog is alive and well. - this is the 1st time AI has been used to create a custom vaccine for a dog (and it worked) - dude is now working on similar vaccines for humans using AI! 2026 is definitely the year we see AI change personalised medicine in a HUGE way so sick

Stealing @ishahjain figure to show the power of spatial metabolomics in embryonic research ! We sectioned straight across the skull and negated the need of brain resection and complicate metabolism in post mortem manipulation !

thx for the highlight! we aim to double our knowledge in metabolism and produce major breakthroughs in cancer and AD treatments in the next 5 years !

Congratulation @ishahjain, beautiful study, and you are amazing to work /workout with lol!

CS Lewis understood

Tune in to today's #UFMedResearch symposium at 12:40 p.m. to learn more about the work of Ramon Sun, Ph.D., who was named the 2026 @UF College of Medicine Research Innovator and Pioneer. Visit research.med.ufl.edu/events/… for symposium details and more information.

Excited to share “Orofacial behaviors, not eye movements, govern neural activity in mouse visual cortex” biorxiv.org/content/10.64898… Summary below...

lol

Early bird registration for METPHYS2026 ends January 31st You don't need an abstract at the time of registration! Multiple short talks will be selected from abstracts sablesys.com/metphys-the-met…

Fantastic visit to PCCM at @UF—great to see the outstanding research infrastructure my colleague and friend @RCSunlab has built, and to interact with fellows and faculty. Until next time.

NEW: Jelly Roll breaks down in tears after his lifelong dream of being invited to become a member of the Grand Ole Opry came true at the end of Joe Rogan's show. Rogan surprised the singer with a message from country music artist Craig Morgan. Jelly Roll threw his headphones to the side when he realized what was happening. "That's like ... it don't get no bigger in country music, bubba." Congrats!

After years of work, we proved lung cancer doesn’t just burn glucose like people thought… It secretly HOARDS it as glycogen — like building a massive internal sugar vault. Normal lung → almost no glycogen Earliest precancerous lesions → glycogen already piling up Full invasive lung adenocarcinoma → tumors absolutely stuffed with stored sugar KRAS-mutant cancers → glycogen levels off the charts The craziest part? When WE knocked out the ability to store glycogen, tumor initiation and progression nearly stopped. Cancer needs that hidden sugar stockpile to grow and spread. This flips everything we thought we knew: it’s not just about glucose uptake — it’s about cancer turning itself into a glycogen warehouse to survive stress, chemotherapy, and metastasis. Selective glycogen-targeting drugs could starve tumors while normal cells (which barely store any) stay perfectly safe. nature.com/articles/s42255-0… #CancerResearch #LungCancer #Glycogen #Oncology #CancerMetabolism (RT if you want cancer to run out of its secret sugar stash) 🚨

Hope everyone is having an awesome Xmas season!!

Was a pleasure to be part of this study led by Maria Grant, we helped imaging the the gut-bacterial metabolite IPA in the retina (eye), how cool is that ?!?! gut.bmj.com/content/early/20…