This is a topic I am very passionate about, and something I am learning every day. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic. The mindful scientist network.febs.org/posts/the-m… #FEBSnet

Good Sunday, all. Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/2026… @Bims_BiomedNews #keepreading "If you don’t like something, change it. If you can’t change it, change your attitude."- Maya Angelou

Good morning, mito lovers! Here is another wonderful selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/2026… @Bims_BiomedNews #keepreading "I am not one and simple, but complex and many."-Virginia Woolf

Good Sunday, all. The last week has seen some amazing papers in #cancermetabolism and #mitochondrialbiology. Here is the summary, don't miss these papers biomed.news/bims-camemi/2026… @Bims_BiomedNews #keepreading "The universe is wider than our views of it."-Henry David Thoreau

Good Sunday, mitolovers. There is a fantastic selection of papers in #cancermetabolism and #mitochondrialbiology waiting for you: biomed.news/bims-camemi/2026… @biomednews #keepreading "I am not a thing in the world; I am the space in which the world is happening." -Richard Lang

Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite | Nature share.google/sOn5pHwJR5k80Vk…

New review from our group taking a critical look at OxPhos as a cancer target......and suggestions for where the field goes next. Published in @Biochem_Journal portlandpress.com/biochemj/a…

Good Sunday, all. Here is an exciting weekly issue of papers in #cancermetabolism and #mitochondrialbiology, curated for you: biomed.news/bims-camemi/2026… @Bims_BiomedNews #keepreading "And what importance do I have in the courtroom of oblivion?"-Pablo Neruda

Good Sunday, mitolovers. There is a truly exceptional curated issue of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/2026… Biomed News. Don't miss it #keepreading "You have to do nothing to be who you are. Nothing at all."-H. W. L. Poonja

I am following the recent series of pieces "Thinking as a Scientist" with an article on "How to Ask a Biological Question." network.febs.org/posts/think… @FEBSnews This is often easier said than done, as we receive no formal training in this area. I look forward to your views.

Good Sunday, all! Here is a fantastic selection of papers in #cancermetabolism and #mitochondrialbiology curated for you 💥 : biomed.news/bims-camemi/2026… Biomed News #keepreading "Wisdom tends to grow in proportion to one's awareness of one's ignorance."-Anthony De Mello

💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) embopress.org/doi/full/10.10… 🔬Approach: We used a subcutaneous LCMV infection model, tracking virus-specific CD4⁺ T cells. Surprisingly, we found two T-bet⁺ subsets—one producing granzyme B (GzmB) and another expressing Tcf-1, the latter being a TFHprecursor. (2/10) 🌟Key Finding: IFN-γ from T cells drives the TH1 fate and blocks TFHmaturation. When we blocked IFN-γ early, Tcf-1⁺ “precursor” cells fully developed into TFH, boosting germinal center B cells and antibody responses. (3/10) 📊Mechanism: Rather than acting solely via an “autocrine loop,” IFN-γ shapes the microenvironment by acting on other immune cells—likely dendritic cells—thereby steering CD4⁺ T cells toward a TH1-dominant response at the expense of TFH. (4/10) 📌Infections & Vaccines: We also tested other settings—like systemic infections or even MPLA-based immunizations—and consistently observed that reducing IFN-γ can enhance TFH and humoral immunity. Timing is critical for optimal effect. (5/10) 🧬Broader Impact: Our data help explain why some infections trigger robust TH1activity but limited antibody responses, and highlight how precisely timed IFN-γ modulation could improve immunization strategies. (6/10) 🔑Clinical Relevance: In severe or chronic viral infections, TH1-skewed responses can sometimes block high-affinity antibody production. Targeted IFN-γ blockade might tip the balance toward TFH, aiding pathogen clearance or vaccine success. (7/10) 💡Mechanistic Insights: By tuning IFN-γ signals, we can reprogram local lymph nodes and “unlock” TFH potential. This points toward new avenues to combine T cell and B cell–focused therapies for more effective vaccines. (8/10) 👏Huge congratulations to Mirela Kuka, Eleonora Sala, Maria Nelli and all contributors who co-led the study! (9/10) 📖Dive deeper into our research and its implications for antiviral defense and vaccines. We look forward to your thoughts and questions! Full paper here: embopress.org/doi/full/10.10… @SanRaffaeleMI @MyUniSR @ERC_Research @AIRC_it @EMBO @ArmeniseHarvard (10/10) 💬📚

This is a huge decision from the Guardian. I believe too that X has become a polarised political platform that has lost its purpose and sadly, I no longer support it, despite its initial good intention. I will move my activity to @frezzalab.bsky.social theguardian.com/media/2024/n…

#Circadian disruption in #cancer hallmarks: Novel insight into the molecular mechanisms of tumorigenesis and cancer treatment sciencedirect.com/science/ar…

🥳 Happy to share our new preprint where we describe the molecular machinery regulating iron transport between lysosomes and mitochondria, how it controls the melanoma drug tolerant persister state and the consequences of its perturbation on ferroptosis 👉 researchsquare.com/article/r…

Today in @CellCellPress we report a new pathway of ketone metabolism. This BHB shunt generates an orphan family of anorexigenic ketone metabolites that are chemical cousins of exercise-inducible Lac-Phe. Congratulations @mariadolores_mg @Stanford_ChEMH cell.com/cell/fulltext/S0092…

Fantastic opportunity to work with a great mentor on a very fascinating topic! 🔥🔥🔥

Today we are publishing 2 MANUSCRIPTS in @NatureComms 1. @NataliaPardoL discovers the role of nuclear MTHFD2 in centromere stability 2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response. Nuclear Metabolism is on 🔥

🔬 FEBS Open Bio Webinar: Mitochondrial Biogenesis: An in-depth look into the beating heart of the eukaryotic cell 🗓️19th November at 16:00 CET ➡️zoom.us/webinar/register/WN_… ➡️ network.febs.org/posts/upcom… #mitochondria #webinar #FEBSOpenBio #YoungFEBS #FEBS_JS #febsjuniorsection

Last week's papers on #glutamine #cancer and #metabolism via @Bims_BiomedNews biomed.news/bims-glucam/2024… Top pick: Glutamine modulates neutrophil recruitment and effector functions during sterile inflammation pubmed.ncbi.nlm.nih.gov/3950…

ICYMI. The #hallmarks of #cancer #immunoevasion. After the 3 Es, the #3Cs, a new framework from @ClaudiaGalassi9 @IlioVitale @GeneCollector and co. On the cover of @cancer_cell Beatiful design by Cris Iribarren offtwitter. Available at cell.com/cancer-cell/fulltex… @FoxChaseCancer