We study how cells sort important stuff around their insides and to their outsides | Golgi aficionados | @Cornell & @CornellMBG | Tweets by lab members
Joined October 2021
- Tweets 162
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- Followers 878
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Jan 6
Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @ryan_vignogna about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!
Mind the GAP 🚧🕳️🚧
Excited to share the latest preprint from the @Fromme_Lab showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵:
biorxiv.org/content/10.64898…
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Fromme Lab retweeted
13 Nov 2024
Really proud of this paper just out in JCB. At almost every turn, SURF4 surprised us. Amazing PhD student, @jmaldutyte, sleuthed it out.
rupress.org/jcb/article/224/…
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4 Oct 2024
Awesome new paper from @Fran_Bottanelli lab!
4 Oct 2024
ARF1 compartments direct cargo flow via maturation into recycling endosomes
nature.com/articles/s41556-0…
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Fromme Lab retweeted
18 Sep 2024
Columbia will award the 2024 Louisa Gross Horwitz Prize to Scott Emr and Wesley Sundquist for discovering the ESCRT pathway and revealing how it works.
Read more: columbiamed.link/47uD4jS
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Fromme Lab retweeted
17 Sep 2024
Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute.
Please share and apply!
academicjobsonline.org/ajo/j…
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Fromme Lab retweeted
8 Jul 2024
New preprint. More on non-canonical motifs for DDR kinases.
Here we find that Tel1 (yeast ATM) targets D/E-S/T.
... more prevalent than S/T-Q
... NOT shared with Mec1.
May explain how Tel1 plays specialized roles in DNA repair and telomere maintenance.
biorxiv.org/content/10.1101/…
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26 Jun 2024
Big congratulations to @ryan_vignogna on his NIH F32 Postdoctoral Fellowship award!!!
24 Jun 2024
F32 NOA ✔️
Very grateful for mentors @jcfromme & @gregoryianlang and thankful to work in such an awesome place @weillinstitute @Fromme_Lab
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Fromme Lab retweeted
11 Jun 2024
Final version of our latest Kramer story is out! Congrats to @Hongyan_S for leading this effort & Adnan, Dylan, Alessandro, & @nicobuchon too! Read on to learn how Wnt signaling in surprisingly many cell types promotes stem cell proliferation in the gut: sciencedirect.com/science/ar…
22 Feb 2023
New preprint: It's about a gene called Kramer 😉 that controls #WntSignaling & stem cell proliferation in the fruit fly intestine. Congrats to @Hongyan_S @weillinstitute & @nicobuchon @cornellento @cihmid! cc: @SeinfeldTV @Seinfeld2000 @JerrySeinfeld doi.org/10.1101/2023.02.21.5… 1/n
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7 Jun 2024
Super impressive membrane-bound Arf1-AP3 cryoEM structures from the Baker lab!🤩
6 Jun 2024
Check out the latest work from my lab, courtesy of soon-to-be Dr. @Biochem_Batman , who determined multiple #cryoEM structures of the human AP-3 adaptor complex. This was a years-long effort to reconstitute active Arf1-AP3 complexes on lipid nanodiscs biorxiv.org/content/10.1101/…
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26 May 2024
lab alum @FeathersRyan is a DRaGoN master
24 May 2024
Dream team Rish and @FeathersRyan giving a cryoDRGN❄️🐉 lecture and tutorial at #CryoNet in Stockholm! 🤩
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Fromme Lab retweeted
23 May 2024
Happy to share the newest preprint from @HollopeterLab @cornellvet: biorxiv.org/cgi/content/shor…. We propose the Inversin complex works via a dimerization mechanism. You’re probably thinking, “What the $%@! is the Inversin complex?” Let me explain:
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Fromme Lab retweeted
10 May 2024
I'm so excited to finally share the results of my PhD work! Check out this thread for all of the highlights!
Ric1-Rgp1-Rab6 has been the most difficult #cryoEM project I've worked on so far, but I'm so happy with how it came together and what we learned about Rab6 activation!
7 May 2024
We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)
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8 May 2024
Fittingly, the URL for the new AlphaFold3 server is:
GOLGI.sandbox.google.com
#GolgiTime
*apparently it also works for proteins that do not localize to the Golgi, although we don't know why anyone would use it that way
8 May 2024
Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/go…
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7 May 2024
We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)
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7 May 2024
Taken together, our findings allow us to model the orientation of Ric1-Rgp1 on the Golgi membrane and understand how it activates Rab6. (8/9)
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7 May 2024
@ryan_vignogna provided important contributions after @FeathersRyan started his postdoc training with @ZhongingAlong and @HughsonLab. We are grateful for help from @cryomariena and @ktspoth with #cryoEM data collection. #GolgiTime (9/9)
bioRxiv: tinyurl.com/mrk2wk72
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