Click chemist, cell biologist, #chembio & #lipidtime enthusiast, occasional classical pianist (he/him). Also @jeremybaskin@mstdn.science
Joined January 2014
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Feb 6
New paper @JCellBiol! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling — it is an E3 ligase adaptor called SHKBP1 but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team!
rupress.org/jcb/article/225/…
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May 29
How to determine the proteome of cellular compartments?
We established a method to do just that, published in @elife: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLife.111393…
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May 29
Goodbye Dresden and Pillnitz! Had a blast @mpicbg and the ESBOC annual bioorganic chemistry meeting — a #lipidtime #chembio 1-2 👊. Thanks to @nadlerlab and Ben Schumann for the invitation, great to see @FiedlerLab @FedorovaLab and other friends!
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Our May issue is live!
nature.com/nchembio/volumes/…
The cover image depicts the vulnerability of the non-transcribed strand of genes to oxidized guanines and abasic sites
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A new CRISPR-based genetic toolkit enables genome-wide, single-cell gene analysis in fruit flies.
This will speed up gene discovery and reveal insights into brain function, development, and disease. Developed by researchers at @Cornell.
Read more: bit.ly/421Ofi0
ALT A fluorescent microscopy image shows a complex network of glowing green blood vessels against a dark background. The intricate branching pattern resembles tree branches spreading outwards.
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The Booker Lab at the University of Pennsylvania, in Philadelphia, and HHMI is searching for a lab manager. If interested, please apply at the HHMI link below.hhmi.wd1.myworkdayjobs.com/e…
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Apr 25
Thrilled to welcome @mbogyo, @danetteldaniels, @SlavoffL, and Marcey Waters to @CornellChem for today’s annual Chemistry-Biology Interface Symposium!
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Apr 18
I had a blast visiting the @omenndarlingbio @Princeton yesterday! Thanks so much to @tinakim_neuro for hosting my visit! @christhechang @KleinerLabRNA
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Mar 20
Special day @CornellChem: welcoming back PhD alum Xiaoyu Zhang (Hening Lin lab) from @NUChemistry for a phenomenal seminar on targeted protein degradation and chemical immunology!
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Mar 18
I've been leading a big project at Methods in Enzymology over the past year: editing back-to-back-to-back volumes describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇
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Mar 18
Methods in Enzymology, Volumes 726-728: Lipids & Membranes
Vol 726: Detection by Imaging & Lipidomics sciencedirect.com/bookseries…
Vol 727: Dynamics & Interorganelle Transport sciencedirect.com/bookseries…
Vol 728: Metabolism, Lipidation, & Lipid-Protein Interactions: coming soon!
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Feb 23
How moss makes a spiral of leaves through a rotating asymmetric division of the apical cell meristem--our paper is out @CurrentBiology today! @StraussSoe @RichardSmithLab @Joesophila
cell.com/current-biology/ful…
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Feb 14
A Postdoctoral Associate position is available in the Roeder Laboratory at Cornell University in Ithaca, NY with a focus on researching Polyploidy. Apply by March 1. Please spread the word. apps.hr.cornell.edu/recruiti…
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Feb 6
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@RMedzhitov @YaleIBIO
nature.com/articles/s41577-0…
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Lin Luan, Jeremy Baskin @basktastic et al. @weillinstitute @CornellChem identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. hubs.ly/Q04271ml0
#CellSignaling
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Feb 4
Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here @HoganBryceRoge1, @Laura_dta and @tomeveriss describe in detail our assay cascade to identify inhibitors of sterol transport proteins. (1/2) sciencedirect.com/science/ch…
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It was fun writing this book chapter on methods to trace #lipid metabolism.
Congrats to Alec and Helene! Thanks to @basktastic for the invitation to contribute this chapter. #lipidtime
@OHSUNews
sciencedirect.com/science/ch…
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Membrane editing with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles
nature.com/articles/s41589-0…
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