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Ora Furman Lab πŸŽ— @FurmanLab
Joined August 2020
  • Tweets 418
  • Following 479
  • Followers 1,155
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Ora Furman Lab πŸŽ—@FurmanLab
12 May 2024
AlphaFold3 is out (and closed source 🀯😠)! So … how well does it do on peptide-protein complexes? A continuing thread as we run predictions...
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πŸ¦‹ Find us also on bluesky πŸ¦‹ furmanlab.bsky.social
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🚨 actifpTM is now in AF3 🚨 Since our new metric, actifpTM, was determined to be the best for predicting success in designed proteins refolded by AF2 (biorxiv.org/content/10.1101/… by @TimothyPJenkins), we made it available also in AF3!

Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally...

Designing high-affinity de novo protein binders has become increasingly tractable, yet in vitro prioritisation continues to depend on heuristics in the absence of systematic analysis. Here, we...

biorxiv.org
Ora Furman Lab πŸŽ—@FurmanLab
27 Feb 2025
Our work on refining AlphaFold2’s ipTM has been accepted for publication in Bioinformatics @OxfordJournals We have been questioning why ipTM worsens when docking peptides with disordered flanking regions, and modified the calculation to remove this effect. Let’s dive in! πŸ‘‡
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If you want to integrate it in your own AF3 installation, check the 3 files which only need a slight modification (model.py, confidences.py and confidence_types.py): github.com/Kuhlman-Lab/alpha…

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Try it and let us know how it goes! @BenLehner @xiaotianliao @sokrypton @amoseslab
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Ora Furman Lab πŸŽ— retweeted
Clay Kosonocky@kosonocky
2 Sep 2025
🚨The Bits to Binders Competition has concluded!🧬 One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20 tumors Spoiler: They work!
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Ora Furman Lab πŸŽ— retweeted
GAMA Miguel Angel πŸ¦β€β¬›πŸ”‘@miangoar
27 Aug 2025
1/13 🧡 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
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Ora Furman Lab πŸŽ— retweeted
Martin Pacesa@MartinPacesa
25 Jul 2025
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
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1/ 🚨Excited to share our new work in Cell Reports! We reveal how SARS-CoV-2 nucleocapsid protein (NP) directs complement attack on uninfected cells, a surprising immune evasion twist. πŸ”— cell.com/cell-reports/fullte…

Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-media...

Using a cell-culture model, Fahoum et al. demonstrate SARS-CoV-2 nucleocapsid protein (NP) spread from infected to neighboring non-susceptible cells. This elicits NP-driven, antibody-dependent...

cell.com
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4/ πŸ’‘ Heparin analogs (like Enoxaparin) block NP surface binding, preventing immune complex formation and rescuing cells from complement attack. A possible path to reduce immunopathology.
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5/ This was an amazing collaboration with the @lab_wiener and @RouvinskiLab - thank you! πŸ™Œ Graphical abstract below ⬇️ #SARSCoV2 #COVID19 #Virology #CellReports #ComplementSystem #Immunology
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Ora Furman Lab πŸŽ— retweeted
Tomer Tsaban@TomerTsaban
1 Jun 2025
Our paper is out on biorxiv! Very excited to share our results - we find signal peptides might be structurally important for quite a few protein isoforms. Full thread soon!
bioRxiv Bioinfo@biorxiv_bioinfo
31 May 2025
Signal peptides as potential structural modulators of human splice isoforms biorxiv.org/content/10.1101/… #biorxiv_bioinfo
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Ora Furman Lab πŸŽ— retweeted
Boston Protein Design and Modeling Club@ProteinBoston
16 May 2025
If you missed out on Sarel Fleishman's extraordinary talk last night, have no fear - you can check out the recording πŸ‘‡ youtu.be/2aaWh8yVq8U

Designing new and improved functions in natural protein folds

Presented on May 15th 2025 by Sarel Fleishmanabstract:Natural pr...

youtube.com
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Starts in 10 minutes! This will be exciting, join us!
PMC Protein Modules Community@PMC_modularity
24 Apr 2025
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. JesΓΊs Alvardo Valverde (@imbmainz). Register to attend:Β  tinyurl.com/PMCseminar2Β  (1/2)
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Come join for this exciting talk!
PMC Protein Modules Community@PMC_modularity
9 May 2025
Remember to tune in at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. JesΓΊs Alvarado-Valverde (@imbmainz). Register to attend:Β  tinyurl.com/PMCseminar2
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Ora Furman Lab πŸŽ— retweeted
PMC Protein Modules Community@PMC_modularity
9 May 2025
Remember to tune in at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. JesΓΊs Alvarado-Valverde (@imbmainz). Register to attend:Β  tinyurl.com/PMCseminar2

Welcome! You are invited to join a webinar: PMC seminar series. After registering, you will receive...

Welcome! You are invited to join a webinar: PMC seminar series. After registering, you will receive a confirmation email about joining the webinar.

uu-se.zoom.us
PMC Protein Modules Community@PMC_modularity
24 Apr 2025
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. JesΓΊs Alvardo Valverde (@imbmainz). Register to attend:Β  tinyurl.com/PMCseminar2Β  (1/2)
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Ora Furman Lab πŸŽ— retweeted
Julia Varga πŸ‡­πŸ‡Ί πŸ‡ͺπŸ‡Ί@jvarga92
15 Apr 2025
Either if you attended or wanted but could not - please tell us how it works for you!
PMC Protein Modules Community@PMC_modularity
15 Apr 2025
Thanks to everyone who has attended the PMC seminars! We have decided to review the timing of the seminar series. If you have any thoughts about the timing of the seminars (currently 6-7pm CET every 2nd Mon of the month), please fill out this form: forms.gle/VZkU2fWkswxYbrZf8
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Ora Furman Lab πŸŽ— retweeted
PMC Protein Modules Community@PMC_modularity
11 Apr 2025
Remember to join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@UofT) and Dr. Veronica Venafra. Register to attend: tinyurl.com/register-pmc-sem… You can find recordings of previous seminars here: youtube.com/@PMCModularity

PMC Seminar Series Attendee Registration

The Protein Modules Community (PMC) organises seminars every second Monday of the month at 18:00 hr CET, featuring: A senior researcher presenting for 25 minutes 10 minutes for questions. A junior...

docs.google.com
PMC Protein Modules Community@PMC_modularity
25 Mar 2025
Join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@UofT) and Dr. Veronica Venafra. Register to attend: tinyurl.com/register-pmc-sem… (1/2)
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