A prestigious journal for omics and bioinformatics areas. 20 years of excellence since 2003.
Joined January 2020
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158 Photos and videos
Nature research paper: Whole-genome duplication shaped cell-type evolution in the vertebrate brain
go.nature.com/4uwfDAB
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Genomics Proteomics Bioinformatics retweeted
A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency go.nature.com/4mgXR0C
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Genomics Proteomics Bioinformatics retweeted
New online! Single-cell four-omics with CHARM dlvr.it/TT1Fsx
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Nature research paper: Mitochondria directly interact with the nuclear pore complex
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1/3 Excited to share our paper in #GPB
We analyzed obesity genetics in 93,673 Korean individuals using BMI, waist circumference, and obesity severity, revealing shared and distinct genetic features of obesity and related diseases.
doi.org/10.1093/gpbjnl/qzaf1…
#Genetics #Obesity
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2/3 We found East Asian-specific genetic features of obesity. Notably, East Asian populations showed stronger genetic correlations between abdominal obesity and related diseases, highlighting the importance of ancestry-specific studies.
#GPB #HumanGenetics #ObesityResearch
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3/3 Both single-trait and multiple-trait PRS models stratified risk for obesity, hypertension, and type 2 diabetes, with the multiple-trait model performing especially well.
These findings support the value of multiple-trait PRS in precision medicine.
#PRS #PrecisionMedicine
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A GPB study employs spatial ATAC-seq to construct chromatin accessibility landscapes in breast cancer, revealing three cross-patient functional modules and two spatial subclones with divergent epigenetic profiles that correlate with patient prognosis.
doi.org/10.1093/gpbjnl/qzag0…
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A GPB study presents a single-cell transcriptomic atlas of the mouse thymus, revealing age-related decline of CD8 T cells and Smad4/Smad7, and dendritic cell–DP-2 T cell interactions via MHC-II that promote T cell development.
doi.org/10.1093/gpbjnl/qzag0…
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A GPB study introduces wellDR-seq, a Nanowell-based method for direct co-sequencing of CNAs and transcriptomes in single cells, revealing ancestral subclones, epithelial lineages, and gene dosage effects in ER breast cancer. @Ruli_Gao
doi.org/10.1093/gpbjnl/qzag0…
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A GPB study introduces MetaDIA, a DDA-free database reduction strategy for DIA gut metaproteomics, which leverages taxonomic abundance and peptide detectability to drastically shrink search space while maintaining DDA-library-level accuracy.
doi.org/10.1093/gpbjnl/qzag0…
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A GPB study about urinary proteomics biological basis, analytical strategies, DDA/DIA roles, cross-disease signatures, and AI-driven multi-omics integration toward precision medicine.
doi.org/10.1093/gpbjnl/qzag0…
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A GPB study introduces a protein language model (MPCutter) to predict protease-specific substrate cleavage sites.
doi.org/10.1093/gpbjnl/qzaf1…
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Excited to share that our collaborative work with Prof. Chuan He’s team at the University of Chicago that developed the first spatial RNA modification sequencing technology (m6A-ARTR-DBiT) has been published in @naturemethods 🥳🥳
nature.com/articles/s41592-0…
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Nature research paper: αKG-mediated carnitine synthesis drives DNA repair via histone acetylation
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Nature research paper: Cold-induced peptide signalling secures pollen resilience and crop yield
go.nature.com/4x5kCKY
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A GPB study about in situ multi-omics system that reveals bacterial cell symbiosis and development in deep-sea mussels
doi.org/10.1093/gpbjnl/qzaf1…
mp.weixin.qq.com/s/NgNIula7J…
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Artificial intelligence is not replacing human intuition in maths and physics, but reimagining how questions are asked, explored and understood
go.nature.com/4vG4Vsl
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Researchers say they have used a precise genome-editing technique called base editing to alter the genome of human embryos for the first time
go.nature.com/3RLdK5v
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A GPB study expands the "ubiquitin code," revealing how atypical K6 ubiquitin chains regulate serine uptake, transporter endocytosis, and nutrient sensing via the Tor1-Npr1-Par32-Gnp1 axis.
doi.org/10.1093/gpbjnl/qzag0…
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