Genomes are constantly exposed to damage. Failure to repair DNA lesions leads to mutations, which can contribute to neurodegeneration, aging, and cancer!
Congratulations to Ali El Zein for his Master's Thesis on "Characterizing the role of nucleases in a Nucleotide Excision Repair-independent pathway in response to UV damage" @SarahSertic1981 ππ
"Protein factors regulating genome stability at non canonical chromosomal structures in normal and cancer cells" Prof. Marco Muzi Falconi project approved by Call for proposals 2024 at AIRC Foundation #AIRC#Unimi#bioscienze_Unimi#lastatalemilano#innovation πππ
The research group will work on a new gene involved in tumor development and understand the role of structural modifications of chromosomes in genomic instability and tumorigenesis.
A very nice conclusion for 2024!
doi.org/10.1093/narmme/ugae0β¦
A good collaboration between different labs! Thanks for reaching a great milestone π
Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!
You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond
Registration will open by June 2025
Very excited to share our new publication on direct detection of rNMPs embedded in DNA by Nanopore sequencing π
@nanopore keeps on revolutionizing science π
Thank you so much @GPathologies for this great opportunity! This has been the most important experience of my career β€οΈ
Direct detection of ribonucleotides embedded in DNA molecules by Oxford Nanopore sequencing, based on ribonucleotides-induced alterations in basecalling features, currents, and dwell times: nature.com/articles/s42003-0β¦@GPathologies@lavinia_grasso
A new review from the @GPathologies group! β‘οΈ Summarizing all the relevant aspects of G-quadruplex biology by combining/discussing results from different works expecially cutting-edge experimental evidence.
Take a look!
Great news today! Muzi-Falconi's lab is happy to share is work on Haspin and its important role during spindle orientation and tissue morphogenesis together with ARHGAP11Aπππ
If you missed the live webinar, here is the recorded @NIH VideoCast:
"DNA Repair: Functional studies of APE1/2 in genome integrity and cancer"
videocast.nih.gov/watch=4629β¦
Glad to have an opportunity to have a video conference talk to the NIH DNA Repair Interest Group on June 13, 2023 at 12:30pm.
"Functional studies of APE1/2 in genome integrity and cancer etiology" @EMGSUS@FASEBorg@UNCCBiologyoir.nih.gov/sigs/dna-repair-β¦