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Ying Ge Research Lab @Ge_Lab_UW

Mass spectrometry-based proteomics group studying cardiovascular disease @ UW-Madison. Account handled by the students🫀🧀 ge-lab-uw.bsky.social

Joined March 2019
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  • Followers 2,293
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Ying Ge Research Lab@Ge_Lab_UW
22 Aug 2023
Replying to @Ge_Lab_UW
If you are interested in utilizing our photocleavable surfactant Azo for your protein applications (bottom-up MS, top-down MS, protein extraction), it’s available for purchase below from Sigma!⚡️⬇️ sigmaaldrich.com/US/en/produ…

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The Ge Lab is enjoying the Southern California sunshine at #ASMS2026! ☀️🌊 Be sure to check out our presentations throughout the week 👇
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Huge congratulations to our amazing Hsin-Ju (Ruby) Chan for receiving the highly competitive American Heart Association Predoctoral Fellowship! 🫀🎉
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🎉 Check our our new publication in Circulation: Heart Failure, where @KalinaReese & Dr. Zhan Gao utilized a novel serial extraction workflow for global top-down proteomics to characterize Hypertrophic Cardiomyopathy (HCM) proteoforms. 👇 ahajournals.org/doi/10.1161/…

Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertro...

BACKGROUND: Hypertrophic cardiomyopathy (HCM) has traditionally been regarded as a disease of the sarcomere; however, it is in the midst of a paradigm shift with growing recognition of contributions...

ahajournals.org
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The Ge lab had a great Friday morning welcoming back lab alumni @jakemelby3 & Dr. Melissa Pergande (BU) for the CVRC Career Panel! 🧑‍🔬 Huge thanks to all panelists for sharing their incredible journeys. ❤️
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Ying Ge Research Lab retweeted
Consortium for Top-Down Proteomics@TopDownProteome
1 Oct 2025
Join us Oct. 16 for the VENDOR SHOWCASE at Proteoform Thursday. Great lineup of speakers presenting the latest tech and apps for top-down proteomics. us06web.zoom.us/meeting/regi… #proteomics #massspec #proteoforms #Thermo #Bruker #Sciex #Agilent #NewObjective #ImmPro
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In our newest publication, we reveal the structural heterogeneity of AMPK -a heterotrimeric complex that acts as a master regulator of cellular metabolism- using integrated native and denatured top-down mass spectrometry (TDMS)! Check it out below 👇 pubs.acs.org/doi/full/10.102…

Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated...

Adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric complex (αβγ) that serves as a master regulator of cellular metabolism, making it a prominent drug target for various...

pubs.acs.org
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Congratulations to Dr. Kalina Rossler on a successful thesis defense! Your years of service & friendship to the lab will forever be cherished. You did it, Doctor! 🫀🎓🎉 #ProudMoment
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Huge congratulations to Emily Reasoner on a successful PhD defense! All those years of hard work, research, and perseverance have paid off — Dr. Reasoner is official! 🧠🎓👏 #Lucky18
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Check our our recent collab in @NatureCVR ! Congratulations & many thanks to Ieng Lam Lei & @PaulTangMD for the opportunity to be part of such a great project! 🫀💪
Nature Cardiovascular Research@NatureCVR
22 May 2025
Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. doi.org/10.1038/s44161-025-0… rdcu.be/enbAz
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Ying Ge Research Lab retweeted
Paul C. Tang@PaulTangMD
23 May 2025
Heartfelt thanks to Ienglam Lei & all collaborators on this very exciting trip down the rabbit hole of organ preservation biology. So many impactful avenues for molecular science to explore in modern surgery. We thank all who supported including @AATSHQ @ThoracicSurgFnd and NIH
Nature Cardiovascular Research@NatureCVR
22 May 2025
Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. doi.org/10.1038/s44161-025-0… rdcu.be/enbAz
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🚨Paper Alert🚨 We've developed the first nondenaturing online 2D-LC method for native top-down MS, enabling rapid structural analysis of endogenous protein complexes. 🧬⚡ #MassSpec #Proteomics #nTDP pubs.acs.org/doi/10.1021/acs…

Native Top-Down Proteomics of Endogenous Protein Complexes Enabled by Online Two-Dimensional Liquid...

Protein complexes are essential for virtually all biological processes, yet their structural characterization remains a major challenge due to their heterogeneous, dynamic nature and the complexity...

pubs.acs.org
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#ASMS2025 The Ge Lab wrapped up Wednesday & Thursday with some *popular posters* from Dr. Gao, Emily, Liam, and Anna Grace!
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#ASMS2025 Fantastic talks today from Andrew and Holden! Great job!
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Ying Ge Research Lab retweeted
Females in Mass Spectrometry (FeMS)@FemalesInMS
2 Jun 2025
Thank you all for attending the #FeMS networking session at #ASMS2025! Special thank you to @livia__se for delivering an inspiring keynote! And thank you to our volunteers for helping make this event happen!
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#ASMS2025 Congratulations to Ruby and Matthew on their fantastic oral presentations!
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#ASMS2025 We had some tasty seafood at our Ge Lab reunion dinner last night! So happy to see familiar faces at our favorite conference 🦀🦪🍰
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#ASMS2025 The Monday poster session was a hit for the Ge Group! Thanks to everyone who stopped by to see Rob, Mallory, & our alumnus Jake Melby (now at Astrazeneca)! 🦀
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Ying Ge Research Lab retweeted
Consortium for Top-Down Proteomics@TopDownProteome
29 May 2025
Join us for #Proteoform Thursday June 19 as Juan Vizcaíno presents "The Implementation of Open Science Practices Can Enable A Faster Development Of Top-Down Proteomics" #proteomics #TeamMassSpec #ASMS2025 us06web.zoom.us/meeting/regi…
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#ASMS2025 Congrats to our fearless leader @yingge2121 for a great presentation during Agilent's HRAM User Group Meeting yesterday!
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The Ge Group is enjoying some weekend fun before #ASMS2025 kicks it into high gear tomorrow! #CrabbyForMassSpec
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