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Genetics News @GeneticsRoundup

The latest genetics research and news, including journal and media articles. #Genetics @GeneOfTheDay @IMPC

Joined May 2018
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Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes journals.plos.org/plosgeneti… #Trypanosoma #Genetics #openaccess #AfricanSleepingSickness

Identification of a novel base J binding protein complex involved in RNA polymerase II transcript...

Author summary Trypanosoma brucei is a parasitic protozoan that causes African sleeping sickness in humans. The genome of T. brucei is organized into polycistronic gene clusters that contain multiple...

journals.plos.org
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Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome journals.plos.org/plosgeneti… #Genetics #RareDisease #morphometry #development #OpenAccess

Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology...

Author summary Craniofacial anomalies are extremely common, accounting for one third of all birth defects, but even when the responsible genes are known, it often remains to be determined exactly how...

journals.plos.org
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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans nature.com/articles/s41588-0… #genetics #metabolism #kidneydisease #GWAS
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Incremental data integration for tracking genotype-disease associations #genetics #mousemodels #diseaseresearch journals.plos.org/ploscompbi…

Incremental data integration for tracking genotype-disease associations

Author summary Human diseases are often caused or influenced by genetic factors. The link between a particular gene and a specific disease is well-established in some cases. However, the roles of...

journals.plos.org
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Genetics News retweeted
IMPC@impc
5 Feb 2020
Missed the @emblebi release? Check out our article on how IMPC researchers are using new categorisation systems to find new candidate genes associated with #raredisease. #genetics #data #mouseresearch mousephenotype.org/news/how-…
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The @impc has been 'shining a powerful light' on the dark genome. #darkgenome #genetics #raredisease
IMPC@impc
4 Feb 2020
The Deep Genome Project: experts outline how mouse genetics holds a vital role in disease research and precision medicine. Read how this project could transform #biology, #medicine, and global health. #genetics #mouseresearch mousephenotype.org/news/impc…
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Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes #genetics #breastcancer #GWAS nature.com/articles/s41588-0…
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FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease #genetics #mousemodels #Alzheimers nature.com/articles/s41467-0…
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Genetics News retweeted
IMPC@impc
4 Oct 2019
"This study would not have been possible without the IMPC" mousephenotype.org/blog/2019…

Study Uncovers 198 Genes Associated With Brain Morphogenesis in Mice | IMPC | International Mouse...

With a contribution from the IMPC, recent research, published in Nature Communications, has identified 198 genes associated with brain morphogenesis in mice – 83% of these constitute genes newly...

mousephenotype.org
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Gene Ontology Causal Activity Modeling (GO-CAM) moves beyond GO annotations to structured descriptions of biological functions and systems nature.com/articles/s41588-0… #genetics

Gene Ontology Causal Activity Modeling (GO-CAM) moves beyond GO annotations to structured descrip...

Nature Genetics - To increase the utility of Gene Ontology (GO) annotations for interpretation of genome-wide experimental data, we have developed GO-CAM, a structured framework for linking...

nature.com
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Synergistic effects of common schizophrenia risk variants nature.com/articles/s41588-0… #genetics
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Genetic behavioral screen identifies an orphan anti-opioid system science.sciencemag.org/conte…
MNS1 variant associated with situs inversus and male infertility nature.com/articles/s41431-0… #genetics

MNS1 variant associated with situs inversus and male infertility

European Journal of Human Genetics - MNS1 variant associated with situs inversus and male infertility

nature.com
Evaluation of methods to assign cell type labels to cell clusters from single-cell RNA-sequencing data rna-seqblog.com/evaluation-o… #genetics

Evaluation of methods to assign cell type labels to cell clusters from single-cell RNA-sequencing...

Identification of cell type subpopulations from complex cell mixtures using single-cell RNA-sequencing (scRNA-seq) data includes automated steps from normalization to cell clustering. However,...

rna-seqblog.com
Genetics News retweeted
Gene Of The Day@GeneOfTheDay
20 Sep 2019
Today’s #GeneOfTheDay is #Got1. Human diseases associated with this gene include Atrial Fibrillation. Mice with this gene inactivated exhibit prolonged RR interval and decreased heart rate. More data here: bit.ly/Got1gene
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Ultrarare variants drive substantial cis heritability of human gene expression nature.com/articles/s41588-0… #genetics
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From a database of genomes to a forest of evolutionary trees nature.com/articles/s41588-0… #genetics

From a database of genomes to a forest of evolutionary trees

Nature Genetics - Inferring adaptation, migration and population history would be profoundly easier if we could use the genomes that we sequence to infer the true genealogical history of each...

nature.com
A reference genome for pea provides insight into legume genome evolution nature.com/articles/s41588-0… #genetics
Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers nature.com/articles/s41588-0… #genetics
Adaptation of host transmission cycle during Clostridium difficile speciation nature.com/articles/s41588-0… #genetics

Adaptation of host transmission cycle during Clostridium difficile speciation

Nature Genetics - Genomic analysis of 906 Clostridium difficile strains shows that this enteropathogen is undergoing speciation, which is linked to the selection of genes involved in sporulation...

nature.com
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