The Gestwicki Lab @UCSF uses #chemicalbiology and #biochemistry to understand the #proteostasis network. This account is student run.
Joined July 2019
- Tweets 147
- Following 262
- Followers 1,068
- Likes 193
10 Photos and videos
3 Jul 2024
Proud to share this publication by our postdoc, Shweta Devi! It offers new insights into the interaction capabilities of the TPR domain to EEVD-like motifs in nonchaperone proteins.
jbc.org/article/S0021-9258%2…
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20 May 2024
Excited to share the work done by @taiawu and Zach Gale-Day on DSFWorld: an online open-source software that streamlines the planning and analysis of DSF experiments!
onlinelibrary.wiley.com/doi/…
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15 May 2024
Interested in learning how dyes might help in characterizing protein activity?
We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding!
go.nature.com/4ajNRNp
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Gestwicki Lab retweeted
1 Jun 2023
First woman to graduate from MIT was a chemist. She applied chemistry to issues like nutrition - a pioneer ahead of her time in many different ways #WomenInSTEM
31 May 2023
Ellen Swallow Richards became MIT’s first female graduate when she earned her BS in chemistry on May 31, 1873 — 150 years ago today.
ALT Black and white portrait photo of Ellen Swallow Richards .
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16 May 2023
We’re thrilled to have Nick joining us!
An alum of Prof. Jeff Kelly's lab, Nicholas Yan looks forward to a postdoc position in @UCSF's @GestwickiLab and @SouthworthLab, where he'll use cryo-electron microscopy to explore the structural basis of small molecules that target amyloid fibrils. More: scripps.edu/2023grads
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26 Oct 2022
Congratulations to our amazing postdoc @proteins_emma on winning a poster award at the Protein Folding Dynamics Gordon Research Conference!!! It’s a well-earned testament to her brilliance & creativity!
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5 Oct 2022
Huge congratulations to @CarolynBertozzi !!! What a well deserved honor.
5 Oct 2022
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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As part of the #QBIChemBio22 Symposium today, @jadoudna, Nobel Laureate, co-inventor of #CRISPR-Cas9 & Professor at @UCSF/@UCBerkeley will participate in a Twitter Space hosted by Jason Gestwicki. Tune in at 1:30 PT to hear about her work!
qbi.ucsf.edu/twitter-space-d…
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Gestwicki Lab retweeted
21 Jul 2022
Jumping around the mutation alphabet to hit cancer! Our new work covalent targeting of KRAS G12S is online: nature.com/articles/s41589-0… Interested in more? The Zhang lab (thezlab.org) at @UCBerkeley is recruiting:)
21 Jul 2022
#G12S The Next #KRAS oncogene targeted by covalent chemistry by @bignerdzzy who just started his lab @UCB_Chemistry (thezlab.org). Next up G12R. nature.com/articles/s41589-0…. @UCSFCancer @HHMINEWS @UCSF
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Gestwicki Lab retweeted
19 Jul 2022
Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way...cell.com/cell-chemical-biolo…
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19 Jul 2022
Another great collaboration out today!
19 Jul 2022
Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way...cell.com/cell-chemical-biolo…
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Gestwicki Lab retweeted
18 Jul 2022
…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome!
cell.com/cell-chemical-biolo…
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19 Jul 2022
It was fun to be a part of this exciting work!
18 Jul 2022
…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome!
cell.com/cell-chemical-biolo…
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Gestwicki Lab retweeted
22 Jun 2022
I concur. I confirm that new PIs will do everything to make their mentees successful! I contend that other hashtags are also cool. I also confess that I’m a new PI @UCB_Chemistry and we are recruiting thezlab.org/
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Gestwicki Lab retweeted
16 Jun 2022
Happy to share the @biorxivpreprint for my first bit of work w/ @aliceyting. Together with @heegwangroh, we built a simple and versatile single-component luminescent biosensor for detecting the SARS-CoV-2 spike protein.
biorxiv.org/content/10.1101/…
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7 Jun 2022
Check out our latest review article on non-canonical Hsp70 interactions—out now in Cell Stress & Chaperones! With the recent explosion of studies mentioning them, @oletaknowsstuff & Jason thought this timely. We hope it inspires new important research! link.springer.com/article/10…
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Gestwicki Lab retweeted
3 Jun 2022
Excited to co-direct the Tau Center Without Walls @tauCWOW with Alison Goate @SinaiBrain and @GeschwindLab, working with awesome colleagues @dlswaney @grinberg_t @timschang @TheBiocheminist and wonderful trainees!
3 Jun 2022
Projects led by our PIs will use multiomics & functional genomics #CRISPR screens to understand molecular & cellular differences in gene expression & cell function due to H1/H2 haplotype inversion leading to new therapeutic targets for treating tauopathies geschwindlab.org/cwow/
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Gestwicki Lab retweeted
2 Jun 2022
Absolutely thrilled to have this work published with RSC! Thank you again to my mentor @BalynZaro and co-authors Sara, Kate, and @Chemystified
Check out my pinned tweet for a more detailed thread!
2 Jun 2022
🔥 New advance article for RSC Chemical Biology! 🔥 @BalynZaro et al @UCSF with the #proteomic characterization of phagocytic primary human monocyte-derived #macrophages! #chembio
🧐Read the #TransparentPeerReview #OpenAccess article 👉ow.ly/ptN550JkYjh
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24 May 2022
That moment when @_heyheyMONET’s #PPGRetreat poster is so good you have to stop & check it out.
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Gestwicki Lab retweeted
23 May 2022
Congrats to Taia Sean Wu @GestwickiLab, winner of the @UCSF Chancellor Award for Public Service. @taiawu decided to pursue a PhD in science after seeing the beauty of a protein structure at age 22. Now she works to give homeless youth the same opportunity.tinyurl.com/mr35aedu
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