@GeschwindLab profile picture
Geschwind Lab @ UCLA @GeschwindLab
Joined September 2019
  • Tweets 55
  • Following 63
  • Followers 1,185
8 Photos and videos
Thanks to Pico Caroni, @AllenInstitute and other organizers/sponsors for a great inaugural conference on the Neurobiology of Mental health. Fantastic program and setting in Thun, Switzerland. @LakeConferences
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Geschwind Lab @ UCLA retweeted
Michael Gandal@mikejg84
24 May 2024
New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment. Major developmental shifts in #genetic reg., New colocalized risk genes at ~60% of #psych #GWAS loci. #PsychENCODE24 science.org/doi/10.1126/scie…

Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain

Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain....

science.org
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Geschwind Lab @ UCLA retweeted
Nadav Ahituv@NadavAhituv
24 May 2024
Characterizing >100,000 sequences in primary neurons and organoids and deep learning to decode regulatory activity. Amazing work from @Chengyu_Deng_, @seawhalen, Katie Pollard, @LabNowakowski and others as part of #PsychENCODE in @ScienceMagazine. science.org/doi/10.1126/scie…

Massively parallel characterization of regulatory elements in the developing human cortex

Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation...

science.org
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Excited to announce our new pivotal work on autism in the latest #PsychENCODE collection, science.org/doi/10.1126/scie… see also @MarkGerstein, @mikejg84 #autism #genomics

Molecular cascades and cell type–specific signatures in ASD revealed by single-cell genomics

Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they relate to genetic susceptibility in this...

science.org
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This represents the culmination of years of work by the @NIMHgov #PsychENCODE consortium! furthering our understanding into the genetic and molecular mechanisms of neuropsychiatric conditions🧠🧬 Read more in @ScienceMagazine: science.org/collections/psyc… #Genomics #Neuroscience

PsychENCODE2 | Science | AAAS

science.org
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Proud of our UCLA CART colleagues!
UCLA CART@UCLACART
24 May 2024
A study co-led by researchers at UCLA CART has found distinct brain connectivity patterns in six-week-old infants at risk for developing autism spectrum disorder (ASD). uclahealth.org/news/release/…
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Our latest publication led by Yonatan Cooper identifying new dementia risk genes using MPRAs to screen noncoding GWAS variants of neurodegenerative disorders w/ functional validation in neurons and microglia @MartinUCSF @srikosuri @giovannicoppoIa science.org/doi/10.1126/scie…

Functional regulatory variants implicate distinct transcriptional networks in dementia

High-throughput functional analysis reveals cell-type-specific regulatory networks that mediate genetic risk for dementia.

science.org
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Our latest publication from Chris Hartl characterizing brain-wide and brain region-specific gene co-expression, providing a framework to contextualize neuropsychiatric genetic risk, supporting polygenic models of disease go.nature.com/3iBPvkL @kasper_lage @alexisjbatte

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Dr. Geschwind recently served as a witness in a congressional hearing coordinated by Congresswoman Karen Bass. His testimony focused on introducing Autism Spectrum Disorder. Take a few minutes to listen to Dr. Geschwind's statement: youtu.be/V7qgpVf-_EI?t=887.

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Geschwind Lab @ UCLA retweeted
Jordan Smoller@jorsmo
4 Jun 2021
Announcing the 1st Annual Conference on Precision Psychiatry! Grateful to our amazing speakers @NIMHDirector @AllofUsCEO @WrayNaomi @royperlis @GregSimonKPWHRI @clesemartin @CRodriguezMDPhD @GeschwindLab @tanzeemc @Stanford_PMHW more! RT & Register here: mghcme.org/precision-psychia…
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Geschwind Lab @ UCLA retweeted
Aaron Gordon@Aaron_Gordon1
22 Feb 2021
Our paper looking at the long-term maturation of cortical organoids is out! rdcu.be/cfDQt #organoids #brainorganoids TL;DR - human cortical organoids start to resemble postnatal cortical development after 250-300 days of culturing

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Thrilled to share that UCLA received a $29M gift to establish a center within the Institute for Precision Health (IPH). which will enable Scientists & physicians to work side by side to examine the role of genetics in disease and develop therapies that improve patients’ lives.
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Dr. Geschwind leads IPH and played a major role in securing this gift. We are very thankful to our donors, Dr. Allen and Charlotte Ginsburg! Read more: newsroom.ucla.edu/releases/u…

UCLA Health receives $29 million gift to establish center in precision genomic medicine

The Ginsburg Center builds on teamwork among scientists and physicians to advance research, enhance patient care for genetic conditions.

newsroom.ucla.edu
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Geschwind Lab @ UCLA retweeted
WashU Medicine Genetics@WashUGenetics
11 Feb 2021
Don't forget to join us for the Spring 2021 Seminar Series today at noon! Speaker is Daniel Geschwind, MD, PhD, from @UCLA. Here's the Zoom webinar link: wustl-hipaa.zoom.us/j/925888… #WashUGen @GeschwindLab
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Geschwind Lab @ UCLA retweeted
Finding Genius Podcast@finding_genius
16 Jan 2021
Replying to @UCLAHealth
@UCLAHealth @GeschwindLab Making Sense of Sequencing: Exome Sequencing Analysis and What's Next. Listen to it here: bit.ly/2XIgOA4 Episode also available on @ApplePodcasts: apple.co/30PvU9C #geneexpression #genetics #genomics #sequencing #Findinggeniuspodcast
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Geschwind Lab @ UCLA retweeted
Biological Psychiatry@BiologicalPsyc1
10 Nov 2020
Now out! From @GeschwindLab @UCLA : Abnormal social and repetitive behaviors and elevated striatal dopamine, a molecular hallmark of human psychosis, in a Maternal Immune activation non-human primate model biologicalpsychiatryjournal.…
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Geschwind Lab @ UCLA retweeted
Gokul Ramaswami@Gokul_Ramaswami
25 Sep 2020
Proud and excited to share our work on multi-omic integration in Autism! 1/4 nature.com/articles/s41467-0…

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Geschwind Lab @ UCLA retweeted
Dr. Rebecca Walker@RebLWalker
24 Aug 2020
My commentary on integrative genomics for the interpretation of genetic loci implicated in neurodevelopmental disorders is out today in @BiologicalPsyc1!! I had a lot of fun writing this and reflecting on all that I’ve learned from the great @GeschwindLab authors.elsevier.com/a/1bdLV…
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Geschwind Lab @ UCLA retweeted
Jerry Wang@jerrywangbio
18 Aug 2020
Very privileged to have completed this project with @Gokul_Ramaswami and @GeschwindLab. We applied gene co-expression network analysis to the human spinal cord to identify the processes and cell-types most susceptible in ALS. biorxiv.org/content/10.1101/…

Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotro...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease defined by motor neuron (MN) loss. Multiple genetic risk factors have been identified, implicating RNA and protein metabolism and...

biorxiv.org
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Excited to share our publication by @vivekenigma and @timschang where we use a multi-omic, multi-cohort approach to identify robust early and late proteomic changes in Alzheimer's disease and other neurodegenerative dementias, and find that genetic risk is differentially enriched
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across disorders. Link: cell.com/cell-reports/fullte…
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