@Go3than profile picture
Ethan Goldberg @Go3than

Pediatric neurologist; Neurogeneticist; Neurobiologist; Fantasy Baseball player; Amateur chess enthusiast; Dad.

Joined May 2013
  • Tweets 121
  • Following 164
  • Followers 535
9 Photos and videos
Ethan Goldberg retweeted
David R. Liu
@davidrliu
May 13
This work was a wonderful three-institution collaboration among @broadinstitute, @jacksonlab, and @ChildrensPhila co-led by @Andrew_TNelson, Sophie Hill, and Matthew Simon, with key contributions from Jérôme Clatot, @HoltSakai, Jun Xie, @AlexanderASousa, @meirui_an, Guangping Gao. This project was co-directed by Cat Lutz and Ethan Goldberg (@Go3than) . Congratulations to the team! 12/13 science.org/doi/10.1126/scit…

In vivo adenine base editing ameliorates Dravet syndrome phenotypes in a mouse model

Through direct correction of a mutation causing Dravet syndrome, adenine base editing alleviates epileptic and premature mortality phenotypes in mice.

science.org
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We have 2 Research Tech positions to support research related to mechanisms of neurodevelopmental disorders: careers.chop.edu/us/en/job/1… Please share the link. This would be great for a few years prior to applying to MD, PhD, or MD/PhD programs, or transitioning to industry.
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Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons biorxiv.org/content/10.64898…
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New study led by postdoc Sophie Hill in collaboration @GordFishell @YatingWang1 et al: Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome biorxiv.org/content/10.64898…
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Job Alert! Administrative Manager for new Center for Brain Research in Development, Genetics, and Engineering (BRIDGE Center) at the Children's Hospital of Philadelphia to provide admin leadership and support Center operations. Apply here: tinyurl.com/4s5j747p
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Job Alert! Technical Director to lead the Behavioral Evaluation of Advanced Model Systems (BEAMS) Hub of the BRIDGE Center research.chop.edu/bridge at Children's Hosp of Philadelphia. Great for a senior postdoc or research associate w/ expertise in behavior tinyurl.com/ywbhckj9

Center for Brain Research in Development, Genetics, and Engineering

The Center for Brain Research in Development, Genetics and Engineering (BRIDGE) applies innovative technology and advanced model systems to understand basic mechanisms of brain development and...

research.chop.edu
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Ethan Goldberg retweeted
Attila Losonczy@attila_losonczy
24 Jan 2025
Please consider applying for the 2025 Gordon Conference on Inhibition and the preceding Gordon Research Seminar on Inhibitory Cascades in the CNS.  grc.org/inhibition-in-the-cn……Great lineup
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Rare variants in epilepsy- and autism-linked gene SCN2A are associated with malformation of cortical development, supporting role of NaV1.2 in early brain development: doi.org/10.1111/epi.18234 Fun collaboration w/ @nupharm1 @NicolaSpecchio_ @r_guerrini Supported by @NIH_NINDS

Rare dysfunctional SCN2A variants are associated with malformation of cortical development

Objective SCN2A encodes the voltage-gated sodium (Na ) channel α subunit NaV1.2, which is important for the generation and forward and back propagation of action potentials in neurons. Genetic...

onlinelibrary.wiley.com
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New collaboration with @davidrliu to pursue base editing in a Dravet syndrome model. Thanks to @curedravet for your leadership and vision and continued support of our work to improve the lives of patients with Dravet Syndrome. einpresswire.com/article/769…

Dravet Syndrome Foundation Funds Five New Research Grant Awards totaling $1.4M

Dravet Syndrome Foundation announced the recipients of their 2024 research grants at their 15th annual Research Roundtable on December 5th in Los Angeles.

einpresswire.com
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Rising star @ZPRosenthal PGY-3 Resident @PennPsych uses a novel mouse model of electroconvulsive therapy (ECT) and DCS/FD-DOS in humans to show that: ECT generates a hidden wave - CSD - after seizure biorxiv.org/content/10.1101/…

Electroconvulsive therapy generates a hidden wave after seizure

Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to genera...

biorxiv.org
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From postdoc Sophie Hill in a fun collaboration w/ EAP expert @TheyelLab supported by @curedravet : Attenuated Ectopic Action Potential firing in PV interneurons in a mouse model of Dravet Syndrome biorxiv.org/content/10.1101/… The function of EAPs remains under investigation...
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Postdoc Eric Wengert (brain slice physiologist educator extraordinaire) teams up with @PennNGG MDPhD student @sophie_liebs and three @Penn undergrads: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy: biorxiv.org/content/10.1101/…
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We are recruiting to two (2) Tenure-Track Assistant Professor positions in the new BRIDGE Center (Brain Research In Development, Genetics, & Engineering) at The Children's Hospital of Philadelphia/University of Pennsylvania. Details here: apply.interfolio.com/148361
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Ethan Goldberg retweeted
Amy Salovin@ASalovin
21 Mar 2024
Excited for Neuroscience 2024: Mechanisms and Emerging Therapies for Brain Disorders of Childhood. All @CHOPResearch and Penn faculty, staff and trainees are welcome. Join us to celebrate groundbreaking research and network with peers! Learn more: pdss.research.chop.edu/agend…

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Superstar @PennNGG student @sophie_liebs throws the kitchen sink at Layer 1 Ndnf cells to show unique preservation of Ndnf interneuron excitability among the major neocortical GABAergic interneuron subtypes in a mouse model of Dravet syndrome. jneurosci.org/content/early/…

Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome

Dravet syndrome (DS) is a neurodevelopmental disorder characterized by epilepsy, developmental delay/intellectual disability, and features of autism spectrum disorder, caused by heterozygous loss-o...

jneurosci.org
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From postdoc Jade Feng: Kv3 modulator targets cell dysfunction in vitro motor impairment/seizure susceptibility in vivo in mouse model of Progressive Myoclonus Epilepsy Type 7 (EPM7) doi.org/10.1016/j.xcrm.2023.… This preclinical data supported ClinicalTrials.gov ID NCT05873062

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Another fun collaboration w/ @ChrisCurrin & @TPVogels plus @DelemotteLab and Manuel Covarrubias: Jerome Clatot et al. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction | PNAS pnas.org/doi/10.1073/pnas.23…

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Our new paper studying SCN3A Epilepsy in an IPSC system by postdoc Guojie Qu, @PennNGG superstar Julie Merchant, and sodium channel maestro Jerome Clatot is in @Brain1848 at tinyurl.com/37xve8nr Great collaboration w/ the lab of Stewart Anderson @CHOP_Research
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Postdoctoral Fellowship for Academic Diversity at The Children's Hospital of Philadelphia: - $65K salary in Yr 1, increasing in $2K yearly increments - Annual travel ($2K) allowance and supplies ($4K) - Relocation bonus ($5K) - Supervised research training research.chop.edu/services/p…
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When will I stop having to write things like <i>I</i><sub>NaP</sub> in the Figure Legend dialog box when I am uploading manuscripts for review? <b>This wastes <i>a lot</i> of time!</b> The Figure Legends are already included in the Main Text, where they are formatted correctly.
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