Our preprint, "Read mismapping from segmental duplications drives spurious trans associations," is out!
We argue that RNA & DNA read mismapping can lead to false signals in QTLs, Hi-C, GWAS, and gene co-expression.
And there is a way to identify them!
biorxiv.org/content/10.1101/…
NEW PAPER in GBE! Saliva is key for digestion, teeth, immunity & oral health, but how did saliva proteins evolve? We show that SCPP genes expressed in salivary glands evolved rapidly via duplications, losses, & regulatory shifts, esp. in primates, with signs of positive selection
✨ one of the proudest achievements of my lab. Oldie but Goldie. we delineated the sex- and diet-dependent effects of an ancient deletion (>Neanderthal–human divergence) in the 3rd, highly conserved exon GHR (GHRd3). science.org/doi/10.1126/scia…#BioRenderForGrants#ScienceAdvances
Great write-up by Technology Networks on our recent work on switch-like gene expression in humans. It is short, clear, and just a 4-min read. If transcriptomic variation interests you, please give it a look!
Paper: nature.com/articles/s41467-0…
Write-up: technologynetworks.com/genom…
#UBuffalo researchers found nearly 500 human genes that act like light switches—either fully on or off! 💡🧬
Led by Omer Gokcumen, Alber Aqil & Naoki Masuda, the study uncovered genetic patterns linked to fertility, COVID-19, cancer & more.
Read more:
arts-sciences.buffalo.edu/ne…