Assistant Professor, University of California Irvine. All opinions my own #CryoEM ❄️ #ProteinDesign #Biochemistry #MembraneProteins #UCI ☀️
Joined July 2018
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127 Photos and videos
Pinned Tweet
25 Apr 2019
Very excited to start my new role as an Assistant Professor at the University of California Irvine. A very big thank you to my Postdoctoral advisor Yifan Cheng and the absolutely wonderful people in his lab!
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Shane Gonen retweeted
13 Nov 2024
The Lawrence Lab website (lawrence-lab.org) is live and we are hiring!
We combine high resolution structure🔬 and cell biology🧫🧪 approaches to define mechanisms of stress response signaling in health and disease.
Live postings at technician and postdoc levels: PLZ RT!
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9 Oct 2024
Wow, massive congratulations David! @UWproteindesign
9 Oct 2024
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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1 Oct 2024
Is anyone else having issues with @LeicaMicro ? Our GP2 has had issues for a long time and requests over the last few months have gone nowhere
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9 Sep 2024
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28 Aug 2024
I'm happy to finally present our #cryoEM work on Voltage-gated sodium channel 1.8 (Nav1.8) with a bound Tarantula peptide Protoxin-I!!
Fabulous work from Bryan and Stephen 🥳🎉👌
biorxiv.org/content/10.1101/…
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28 Aug 2024
We also saw some large movements of the linker leading to VSDI and took advantage of graphene grids to get massive amounts of particles imaged from very little starting culture. 🥶🔬
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28 Aug 2024
Full length human Nav yield in HEK cells is low and graphene grids ended up being a great alternative to drastic changes to the prep or construct.
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22 Jul 2024
We combined deep learning and comparative modeling to analyze some wicked disulfide rich ion-channel targeting toxins 🐚🐌 - awesome work from Stephen McCarthy in my lab👌 onlinelibrary.wiley.com/doi/…
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28 Jun 2024
It's once again time to order grids. This time for our slated 2027 projects. 🤞we can get some by then
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Shane Gonen retweeted
14 Jun 2024
First preprint from the Wiles Lab! We used an approach we call "Phollow" to study phage replication and transmission by live imaging!
14 Jun 2024
Phollow: Visualizing Gut Bacteriophage Transmission within Microbial Communities and Living Animals biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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13 Jun 2024
When you give a talk at your institute and a neurosurgeon who attended and works on the same system as you asks to collaborate. @QuinaScience @UCIBioSci
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Shane Gonen retweeted
28 May 2024
Now everyone customize/share protein language models for their custom task/dataset via
@GoogleColab 🤓
Paper: biorxiv.org/content/10.1101/…
Colab: colab.research.google.com/dr…
Credit: @LTEnjoy, Zhikai Li, @ChenchenHa42849, @BonnieSwt, Junjie Shan, @XibinBayesZhou, Dacheng Ma, @duguyuan
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