@GregersenLab profile picture
Lea Haarup Gregersen @GregersenLab

Group leader at @UCPH_health, working on RNA-binding proteins and co-transcriptional regulation. Previously at @UPCH_BRIC, @BIMSB_MDC and @TheCrick

Joined November 2020
  • Tweets 69
  • Following 231
  • Followers 436
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❗️5 days left to apply for a PhD position in our group👇
Lea Haarup Gregersen@GregersenLab
Mar 2
🧬 Passionate about transcription? 🚀 We’re recruiting a PhD student in Transcriptional Regulation @UCPH_health in Copenhagen Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab 👩‍🔬👨‍🔬 gregersenlab.com Apply by Apr 10, 2026 tinyurl.com/PhD-CGEN
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🧬 Passionate about transcription? 🚀 We’re recruiting a PhD student in Transcriptional Regulation @UCPH_health in Copenhagen Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab 👩‍🔬👨‍🔬 gregersenlab.com Apply by Apr 10, 2026 tinyurl.com/PhD-CGEN
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What is the function of the RNAPII-interacting SCAF proteins? In our latest work, led by Smaragda Kompocholi, we show that SCAF1 shapes mRNA isoform expression during neuronal differentiation 🧬🧠 Loss of SCAF1 → shorter mRNA transcripts biorxiv.org/content/10.64898…

SCAF1 driven polyadenylation site usage regulates mRNA isoform expression and neuronal differenti...

Accurate co-transcriptional processing is required for correct gene expression of mRNA transcript isoforms under unperturbed conditions, but particularly during development, to ensure tissue-specific...

biorxiv.org
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Thank you to collaborators Gertrud Hjortø, Tom Miller, @JZylicz and support from colleagues at @UCPH_health
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What happens to transcription upon oxidative DNA damage? 🧬💥 RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦 👀 How? Find out in our new preprint👇 biorxiv.org/cgi/content/shor…

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Thank you to everyone involved and support from colleagues at Center for Gene Expression (CGEN), @UCPH_health!
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Key takeaways: 🔍Oxidative damage causes shutdown of transcription, without RNAPII degradation 🔍Stalled RNAPII resumes transcription from within the gene body 🔍PARylation controls early elongation restart 🔍BER and SSBR repair enable RNAPII recovery in the gene body
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This beautiful work, led by Quentin Thomas, revealed a surprising spatial organization of the transcriptional response: • Promoter regions: PARylation governs early RNAPII release • Gene body: DNA damage and repair drive RNAPII stalling
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Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure RNAPII elongation rates across 3,000 genes 🧬genome.cshlp.org/content/ear… Fantastic work led by @liu_haiyue More details below! 👇 #Genomics #Transcription #RNAPII #ElongationRates

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Huge thanks to our amazing team and members with CGEN for fruitful discussions 🙌
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What did we find? ✅ Elongation rates vary between genes ✅…and within genes ✅ Histone marks & elongation factors correlate with rate subclasses
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The computational pipeline independently applies to existing DRB/TTchem-seq datasets - so you can improve the number of genes with single gene elongation rates from existing data, simply by using the new computational pipeline
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Existing methods either rely on indirect estimates or are limited to a handful of long genes. So we built DRB/TTchem-seq2: Short timepoint sampling, new computational framework 📈 leading to a ~7 fold increased individual gene elongation rates measurements!
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❗️One more week to apply for a PhD position in our group! Come join our team of transcription enthusiasts in Copenhagen👩‍🔬👨‍🔬
Lea Haarup Gregersen@GregersenLab
13 Feb 2025
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @uni_copenhagen. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com) Great city and amazing research environment. Deadline March 6 jobportal.ku.dk/phd/?show=16…
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Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @uni_copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com/ Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16…

Gregersen Lab

The aim of the lab is to understand regulation of transcription and co-transcriptional processing in human cells

gregersenlab.com
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We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @uni_copenhagen. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com) Great city and amazing research environment. Deadline March 6 jobportal.ku.dk/phd/?show=16…

Gregersen Lab

The aim of the lab is to understand regulation of transcription and co-transcriptional processing in human cells

gregersenlab.com
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Lea Haarup Gregersen retweeted
Thomas Miller@TCR_Miller
16 Feb 2024
Looking for a #postdoc or #PhD in eukaryotic #DNA replication and #CryoEM? We are recruiting! The positions are fully-funded by the @novonordiskfond and come with access to cutting-edge facilities and fantastic colleagues in #Copenhagen. See links below for more information.
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Happy to be back among old colleagues and friends in Berlin mixed in with amazing science 🧫
MDC-BIMSB@BIMSB_MDC
6 Sep 2023
Proud to showcase a selection of our alumni during session 2 of the Berlin Summer Meeting 2023: Pinar Önal, @baris_tursun @TursunLab, Elena Torlai Triglia, Lea Haarup Gregersen @GregersenLab & @M_Munschauer #mdcBIMSB2023 @MDC_Berlin
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Great opportunity for a postdoc in Copenhagen 👇👇
Kathleen Stewart-Morgan@stewmorganlab
18 Aug 2023
We are recruiting a postdoc for a fully funded position in our group in beautiful Copenhagen! We encourage anyone interested in #DNAmethylation and/or #Bioinformatics to apply. Deadline: 17 September Apply here: employment.ku.dk/faculty/?sh… Please retweet!
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Great opportunity for a PhD position 👇👇
Rune Busk Damgaard@rbdamgaard
7 Aug 2023
📢 PhD scholarship in Copenhagen 🇩🇰 Do you want to... 🧬 study how ubiquitination regulates cellular metabolism in disease states? 👩‍🔬 join an international and ambitious team? ✅Then apply here before 11 Sep to join my team: efzu.fa.em2.oraclecloud.com/…
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