@GroupAzuma profile picture
Azuma Group @GroupAzuma

We seek to uncover the protein cage’s potentials as powerful tools for molecular and synthetic biology @ Małopolska Center of Biotechnology, Kraków, Poland

Joined May 2020
  • Tweets 103
  • Following 264
  • Followers 228
18 Photos and videos
Our new paper is out @NatureComms🎉Mushrooms are a good source of #VitaminB2, but did you know some bacteria produce the same nutrient in #protein 'cages'? Our #CryoEM study reveals their elegant mechanism of enzyme #compartmentalization. @MCB_UJ doi.org/10.1038/s41467-026-7…
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Our story of building a research group in Krakow, now shared with the Japanese community - putting Polish science on their radar. @Yodosha_EM @MCB_UJ doi.org/10.18958/7833-00006-…
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Azuma Group retweeted
Malopolska Centre of Biotechnology UJ@MCB_UJ
6 Oct 2025
#newpaper A new study from the Glatt Lab @MCB_UJ shows that the rare tRNA modification queuosine is added before RNA splicing — not after! 🧬 tinyurl.com/8n4y8p49 @JagiellonskiUni @igorkaczm @science_PhD_UJ @SOLARIS_science
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Azuma Group retweeted
Malopolska Centre of Biotechnology UJ@MCB_UJ
15 Sep 2025
#newpaper @GroupAzuma created a protein cage that safely produces therapeutic peptides like lixisenatide inside bacteria ✅ fully active, ✅ cost-effective, ✅ scalable. Congrats! Full text: url-shortener.me/4ZGQ Press release: url-shortener.me/4ZGT @JagiellonskiUni
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Finally out🎉 We've established a robust and customizable system for otherwise troublesome #RecombinantProtein production. Our #ProteinCage-based method can be a game-changer for your lab work. Check it out>> pubs.rsc.org/en/content/arti… #SyntheticBiology #PeptideTherapeutics @MCB_UJ

Encapsidic production and isolation of degradation-prone polypeptides

Degradation during production and delivery is a significant bottleneck in developing biomolecular therapies. Protein cages, formed by engineered variants of lumazine synthase, present an effective...

pubs.rsc.org
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Oh yeah, another academic degree...@MCB_UJ
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4 days of intensive scientific discussion, supplemented with good food and wine, at a beautiful coast-side village in Cataluna. #EMBOPhysicalVirology @EMBOevents @EMBO @FEBSnews
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Azuma Group retweeted
Alena Khmelinskaia@khmelinskaia
26 Feb 2025
Now online and just in time for WRCon! It was a great journey with a fantastic team across boarders that survived several moves. A big thank you to all involved, and a special shoutout to Neil @KingLabIPD and the @akhmelinlab 🧵 to come…
NatureStructMolBiol@NatureSMB
26 Feb 2025
New online! Local structural flexibility drives oligomorphism in computationally designed protein assemblies bit.ly/4kiM6WW
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ACS Nano@acsnano
25 Feb 2025
.@KoziejLukasz et al @GroupAzuma @MCB_UJ show how a pentameric protein can controllably assemble into #nonquasiequivalent, hollow spherical and cylindrical #proteincages with defined #geometries Read it here 🔗 go.acs.org/cke
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Are you disappointed or frustrated by seeing your #recombinantproteins are truncated or degraded? Here, we have a solution. Encapsidic protein production is now available @biorxiv_bioeng. biorxiv.org/content/10.1101/…

Encapsidic production and isolation of degradation-prone polypeptides

Degradation during production and delivery is a significant bottleneck in developing biomolecular therapies. Here, we show that encapsulation in protein cages formed by engineered variants of a...

biorxiv.org
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thrilled to share the molecular mechanism and the geometrical theory underlying the dynamic, polymorphic assembly of pentamer-based #proteincages and #proteinnanotubes, now published in @acsnano. @MCB_UJ @UniOfYork @CPBM_heddlelab pubs.acs.org/doi/10.1021/acs…

Dynamic Assembly of Pentamer-Based Protein Nanotubes

Hollow proteinaceous particles are useful nanometric containers for delivery and catalysis. Understanding the molecular mechanisms and the geometrical theory behind the polymorphic protein assemblies...

pubs.acs.org
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Azuma Group retweeted
Malopolska Centre of Biotechnology UJ@MCB_UJ
7 Jan 2025
#newpaper Excited to share our latest paper in collaboration with @CPBM_heddlelab : engineered protein cages that self-assemble with metal ions and disassemble on demand with triggers like pH changes. Perfect for advanced drug delivery and biomedical innovation. 🚀🧬 Congrats!
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Azuma Group retweeted
Przemyslaw Grudnik@GrudnikPgrudnik
8 Oct 2024
Replying to @MCB_UJ
@MCB_UJ @JagiellonskiUni is looking for a new Director nature.com/naturecareers/job…

Director - University Professor at the Malopolska Biotechnology Center (254.2024) - Kraków (PL)

MCB, Jagiellonian University, is seeking a new director to continue the development of the institute as a centre of research excellence.

nature.com
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Lovely 😍 This is what I, Yusuke, found on my desk after the habilitation colloquium. @MCB_UJ
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Finally!! Here, we show how pentameric proteins dynamically and controllably assemble into diverse hollow structures, including unique #nanotubes. #cryoEM #nonquasiequivalent #proteincage #bionanotechnology @MCB biorxiv.org/content/10.1101/…

Dynamic assembly of pentamer-based protein nanotubes

The molecular mechanisms and the geometrical theory underlying the polymorphic behavior of protein cages provide a basis for designing ones with the desired morphology and assembly properties. We...

biorxiv.org
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@MCB_UJ
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Azuma Group retweeted
bioRxiv Bioengineering@bioRxiv_bioE
19 Aug 2024
Dynamic assembly of pentamer-based protein nanotubes ift.tt/IYJUD7O #biorxiv_bioE
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Maria, Jędrzej, Vishal, and Yusuke presented our latest results @ArtBioAU. Many thanks to the organizers for such an exciting event. Jędrzej received a reward for his active participation in the discussion! @iNANO_AarhusUni, @AarhusUni_int, #ArtBio2024, @MCB_UJ
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Congratulations Maria, a master of biotechnology with an exceptional mark!! @MCB_UJ
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and this is what we do after that on a beautiful summer day.
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