@HughesDC_Muscle profile picture
Dave Hughes @HughesDC_Muscle

Assistant Professor | @AM_OMRF | Skeletal Muscle, Atrophy, Aging, Protein Quality Control (PQC) | Views my own | 📚💪🏼🇬🇧 #myotwitter

Joined August 2011
  • Tweets 22,259
  • Following 303
  • Followers 10,896
417 Photos and videos
Pinned Tweet
Dave Hughes
@HughesDC_Muscle
20 Nov 2025
Final Version of our article on UBR-box E3 ubiquitin ligases, protein synthesis and skeletal muscle size now online 🚨 | @AJPCellPhys @CraigAGoodman1 @DrAdamPSharples | journals.physiology.org/doi/… Review in this area recently published here: journals.lww.com/acsm-essr/f… #Myotwitter
4
12
2,692
Dave Hughes retweeted
OMRF@OMRF
Jun 3
👏 Way to go!!!
Dr. Chi Fung Lee@ChiFungLeePhD
Jun 3
Great work from @w_zarzycka for the young Investigator award and @HinaLateef for travel award and great talks @ISHR_NAS. we are proud mentors @ChiFungLeePhD @AnnChiaoPhD @OMRF @OUHSC_GPiBS
2
6
674
Dave Hughes retweeted
Harrison Finn, PhD@HarrisonFinn
May 28
In Memoriam: V. Reggie Edgerton - Lieber - The Journal of Physiology - Wiley Online Library physoc.onlinelibrary.wiley.c…

In Memoriam: V. Reggie Edgerton

Click on the article title to read more.

physoc.onlinelibrary.wiley.com
5
16
1,783
Dave Hughes retweeted
Craig A. Goodman@CraigAGoodman1
May 28
Multicellular senescence impairs skeletal muscle recovery following disuse in aging science.org/doi/10.1126/scia…

Multicellular senescence impairs skeletal muscle recovery following disuse in aging

Senescent interstitial cells accumulate in aged muscle and are related to impaired cellular remodeling.

science.org
7
19
1,709
Dave Hughes retweeted
OMRF@OMRF
May 21
We welcomed two new Board Directors and awarded multiple scientists for their research at yesterday's spring Board meeting. Read more: omrf.org/omrf-board-welcomes…
1
2
490
MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo | #myotwitter pubmed.ncbi.nlm.nih.gov/4212…

MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo - PubMed

Since MyoRep detects only pathological atrophy anticipating wasting, it represents an unprecedented tool to predict it early in diseases with local or systemic atrophy. It could also be useful to...

pubmed.ncbi.nlm.nih.gov
1
1
485
Dave Hughes retweeted
Simone Porcelli@PorcelliSimone
May 10
Finally out the data we collected in the over90 200m world record holder. Read if you are interested in knowing how aging can be modified by lifelong training #longevity #physiology journals.physiology.org/doi/… journals.physiology.org/doi/…

One half of the sprinting coin: the oxygen transport cascade of a 91-yr-old female world-record...

A 91-yr-old female set the W90 world record in the 200-m sprint in 2024, surpassing her previous record by 1.13 s. This study characterized her cardiorespiratory fitness, skeletal muscle oxidative...

journals.physiology.org
1
8
39
3,425
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine cell.com/trends/biochemical-…
1
18
49
3,417
Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway #myotwitter pubmed.ncbi.nlm.nih.gov/4210…

Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77...

The maintenance of skeletal muscle mass relies on mitochondrial quality control, including balanced dynamics and mitophagy. Dynamin-related protein 1 (Drp1), a central mediator of mitochondrial...

pubmed.ncbi.nlm.nih.gov
3
4
680
Dave Hughes retweeted
AJP-Cell Physiology@AJPCellPhys
May 7
Brand new #ArticleinPress today! Overactive PDGFRα and PDGFRβ promote distinct phenotypes of skeletal muscle #fibrosis and stiffness, with PDGFRβ also driving #muscle growth (Mariola Gimla et al. @OMRF): ow.ly/Z3xq50YVv10
1
6
16
1,324
Dave Hughes retweeted
Gilles Gouspillou@GGouspillou
May 1
The final version of our latest paper is now online: BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics. sciencedirect.com/science/ar…
1
12
40
2,398
Dave Hughes retweeted
OMRF@OMRF
Apr 30
OMRF's Dr. Sue Bodine was elected and installed as the society’s 99th president. With nearly 10,000 members, the @APSPhysiology is the world’s largest association of physiologists. Read more: omrf.org/omrf-scientist-to-l…
1
4
601
Dave Hughes retweeted
Craig A. Goodman@CraigAGoodman1
Apr 28
Mitochondrial protein import stress causes lysosomal damage and progressive tissue atrophy link.springer.com/article/10…

Mitochondrial protein import stress causes lysosomal damage and progressive tissue atrophy

EMBO Reports - Mitochondrial and lysosomal abnormalities co-occur in aging-related diseases with progressive tissue atrophy. It remains unclear whether these two pathogenic pathways affect tissue...

link.springer.com
13
36
2,596
Dave Hughes retweeted
SofiaZaganelli@SofiaZaganelli
Apr 24
5.5 years and two babies later, my postdoctoral work is finally out in Cell today! So very grateful to everyone who made this possible. Nuclear envelope budding enables export of large transcripts in muscle... sciencedirect.com/science/ar…

5
10
100
9,704
Dave Hughes retweeted
Craig A. Goodman@CraigAGoodman1
Apr 23
It was a privilege to have played a role in this groundbreaking work of @Ma_Jochem, @cobbold_simon & David Komander showing in vivo ubiquitination of glycogen & metabolites in tissues, incl. skeletal muscle, that re-writes the textbooks. @WEHI_research nature.com/articles/s41586-0…

Ubiquitination of glycogen and metabolites in cells and tissues

Nature - Integration of ubiquitin clippases with sortase-based labelling and mass spectrometry reveals that a wide range of non-peptide molecules are ubiquitinated in vivo, and points to a...

nature.com
8
28
1,289
Dave Hughes retweeted
Centre for Muscle Research@UniMelbCMR
Apr 23
Congrats to @Ma_Jochem, @cobbold_simon & David Komander for their new Nature paper, "Ubiquitination of glycogen and metabolites in cells and tissues", that also involved the CMR's @CraigAGoodman1 & @pgregorevic #myotwitter #ubiquitin @WEHI_research nature.com/articles/s41586-0…

Ubiquitination of glycogen and metabolites in cells and tissues

Nature - Integration of ubiquitin clippases with sortase-based labelling and mass spectrometry reveals that a wide range of non-peptide molecules are ubiquitinated in vivo, and points to a...

nature.com
7
11
991
Looking forward to being at #APS2026 later this week 👍🏼🧑🏼‍🔬
American Physiological Society@APSPhysiology
Apr 20
This week at APS: #APS2026 starts this week! ➡️Register (there’s still time!): ow.ly/jUkE50YHfAW ➡️Mobile app: ow.ly/CyQ450YHfFn ➡️Program: ow.ly/Spy350YHfPC ➡️Game changers: ow.ly/5PS250YHfQt ➡️More ow.ly/Spy350YHfPC #WeArePhysiology
1
1
2
833
Dave Hughes retweeted
Craig A. Goodman@CraigAGoodman1
Apr 17
Autophagy selectively clears ER in TNF-α-induced muscle atrophy tandfonline.com/doi/full/10.…

Autophagy selectively clears ER in TNF-α-induced muscle atrophy

Skeletal muscle atrophy is a pathological condition characterized by the progressive loss of muscle mass and function, driven by factors such as disuse, inflammation, and aging. While the ubiquitin...

tandfonline.com
6
11
750
Dave Hughes retweeted
Gilles Gouspillou@GGouspillou
Apr 15
Excited to share our new paper showing that BCL6, a transcriptional repressor, regulates skeletal muscle mass, mitochondrial bioenergetics & may mediate endurance training adaptations. Fantastic collaboration with @MinnaWoo, @JeanPhilippeLG2 & many others! sciencedirect.com/science/ar…

1
9
29
1,929
Dave Hughes retweeted
Craig A. Goodman@CraigAGoodman1
Apr 14
Single-Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity During Human Skeletal Muscle Aging onlinelibrary.wiley.com/doi/…

Single‐Nucleus RNA Sequencing Reveals Muscle Fiber Cell Heterogeneity During Human Skeletal Muscle...

Aging was characterized by a state transition, accompanied by denervation and fatty infiltration. The aged microenvironment was globally altered. BMP and Laminin signaling were involved in enhanced...

onlinelibrary.wiley.com
2
33
1,771
Dave Hughes retweeted
Hailey A Parry, PhD@parry_hailey
Apr 10
New paper dropped! Very excited to share this review I started during COVID. It made its home in my graduate school files for a few years before @phc_mesquita, @Wendy_R_Hood, @kangnianyap, and I got back to it. Check it out! journals.biologists.com/jeb/…

Expanding endurance exercise physiology research: insights from animal migration

Summary: This Review provides a comprehensive comparison of pre-exercise food intake necessary to facilitate fat mobilization and oxidation during exercise in migratory birds, insects, fish and...

journals.biologists.com
3
16
1,357
Load more