Check out their website for more details. abolitionistapproach.com/

How long before Putin Nukes Kiev? What does he have to lose?

JUST IN: 21-year-old dies after workers forget to attach safety rope and push her off 40-meter bridge in São Paulo’s Limeira, Brazil

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The strongest evidence for tadalafil as a longevity candidate is large scale observational. In a propensity matched cohort of 509,788 men with erectile dysfunction, tadalafil over 3 years was associated with 34% lower all cause mortality, 32% lower dementia, 27% lower MI, and 34% lower stroke. Supporting cohorts show the same direction, including a dose dependent gradient: in higher risk men the top PDE5 inhibitor exposure quartile reached a mortality risk reduction of 49%. For a drug discussed as “longevity medicine,” that is close to the ceiling of current human evidence. No drug, tadalafil included, has a completed RCT with lifespan or healthspan as the primary endpoint, so observational signal on hard endpoints is the best the field has, and tadalafil’s is unusually large and consistent. The mechanism is also coherent. PDE5 inhibition raises cGMP, improves endothelial function and NO signaling, and the cardiovascular event data line up with that pathway. That supports causal plausibility for the vascular benefit, though it does not establish a lifespan effect. Disease specific and healthy user bias cannot be ruled out. The disease specific part: ED is itself a sign of vascular disease or dysfunction, which tadalafil’s mechanism can help directly. The healthy user part: wanting to maintain a healthy sex life in older age is a marker of relatively good health. None of this is a recommendation to take tadalafil on your own. It should follow from your individual health and biomarker profile, and only under specialized physician advice and oversight.

JUST IN: Andrej Karpathy, a top AI scientist at Anthropic, is reportedly barred from accessing the company’s most advanced AI model because he is not a U.S. citizen.

هندي يُدعى "دولت جیری جی مهاراج" قرر ترك الدراسة الجامعية والتحول إلى التديّن ونذر نفسه لأمر واحد فقط وهو الوقوف إلى الأبد. السبب؟ هذه العملية الدينية ستوصله في النهاية لرؤية الإله الهندوسي (ماهاديف) حسب اعتقاده. بعض التقارير تقول بأنه منذ 12 عام وهو على هذا الوضع، لم يجلس أو ينم على الأرض بل ينام واقفًا مستخدمًا دعامة. في المقطع أحد المتطوعين يقوم بتنظيف ساقيه بوضع مراهم موضعية ومطهرات للمساعدة في تخفيف التورم والعناية بالحالة الصحية الناتجة عن سنوات الوقوف الطويلة. يُذكر أن الهندي "دولت جیری جی مهاراج" لم يرى الإله المذكور حتى اليوم.

NEW: Amazon researchers are reportedly behind the jailbreak report that led to the U.S. crackdown on Anthropic’s top models.

🚨 UPDATE: 8 people charged in Sex Ring “Underground Bunker” for Paying adults to Rape their Children and Pets — Ages 3-16. Trial delayed as mom pleads guilty and flips on co-defendants In Bibb County, Alabama, eight suspects ran a sex trafficking ring out of an underground bunker where children as young as 3 were drugged, bound, and raped with adults paying to abuse them. Animals were also targeted. Rebecca Brewer and mother of some of the victims, pleaded guilty to sexual torture and nine counts of first-degree kidnapping. As part of the deal she agreed to testify against the other seven defendants. The trial for the remaining suspects has been delayed while the case expands, including a federal investigation into at least one of them. These monsters turned their own kids and pets into victims for profit. How long will it take for every last one of them to face real justice?

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