31 Photos and videos
Ignatova Lab retweeted
24 Oct 2024
The official website for the tRNA2024 Conference has been updated! You can now find the latest presentation schedules, session details, and notification to oral/poster presentation. Stay up to date and plan your presentation:
trna2024kanazawa.jp/
#tRNA2024
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Ignatova Lab retweeted
29 Sep 2024
That's what the pluripotent stem cell field has been waiting for. Own cells, reprogrammed to iPSCs; differentiated into insulin-producing cells, and translanted back into patient, effectively curing type-1 diabetes! One patient. One year. But a tremendous proof-of-concept.
28 Sep 2024
Now online! Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient dlvr.it/TDnc6w
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20 Sep 2024
Highly recommended! PhD students apply
19 Sep 2024
We are looking for a highly motivated PhD student to explore molecular mechanisms of protein synthesis using fast kinetics and cryo-EM. Pls share the link or apply! uu.varbi.com/en/what:job/jobβ¦
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Ignatova Lab retweeted
7 Sep 2024
At Tevard, we're devoted to improving the lives of people with severe genetic diseases like Duchenne muscular dystrophy (DMD). In honor of #WorldDuchenneAwarenessDay, learn more about DMD, and see how you can help raise awareness: bit.ly/3qh209B #WDAD24
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Ignatova Lab retweeted
29 Aug 2024
Preprint alert in collaboration with @fraser_lab !
We identify that deleting GidB, a 16S rRNA methyltransferase, acts as an "automatic braking system" for mistranslation!
Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA biorxiv.org/content/10.1101/β¦
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Ignatova Lab retweeted
29 Aug 2024
We're looking forward to the upcoming RNA Leaders USA Congress. Tevard CEO, Daniel Fisher, will give a presentation on our work to pioneer novel tRNA therapeutics and how our platform is enabling us to advance our pipeline. See the full agenda: bit.ly/3T9n295 #RNALeaders
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Ignatova Lab retweeted
27 Aug 2024
We report many proteins not predicted by the genetic code.
They are stable & abundant O( 10Β³ ) copies / cell.
Generative mechanisms include codon-anticodon mismatches & RNA modifications.
Their abundance depends on codon frequency & protein stability.
biorxiv.org/content/10.1101/β¦
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Ignatova Lab retweeted
27 Aug 2024
Single-cell proteomics helped answer a fundamental question in development:
The molecule mechanisms of symmetry breaking in early mammalian development.
A great collaboration with @MZG_Lab led by @aleks_petelski & @LIwamotoStohl.
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Ignatova Lab retweeted
21 Aug 2024
How to repurpose a #tRNA enzyme into a global stress sensor? Co-led by @CharlesBNader, Swati Gaikwad, Soheila Bahmanjah, w/ Alan Hinnebusch lab, in
@PNASNews, we describe how stress kinase Gcn2 adopts and molds Histidyl-tRNA synthetase as a regulatory hub. bit.ly/3YQbiMk
ALT https://www.pnas.org/doi/10.1073/pnas.2409628121
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Ignatova Lab retweeted
14 Aug 2024
I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer.
nature.com/articles/s41586-0β¦
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Nature research paper: The ribosome lowers the entropic penalty of protein folding go.nature.com/4clH1rM
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1 Aug 2024
Happy (t)RNA day! #RNADay
Thank you to our first author baker Vale @Vblancoca - our terrific guest from @jptosar lab - who orchestrated the baking process.
1 Aug 2024
Happy #RNADay! π
Celebrating in Germany with the incredible scientists/bakers at @IgnatovaLab
Check out our entry for the @RNASociety cake competition! π°π¬
We hope sharing our creation here is as welcomed as uploading a paper on @biorxivpreprintπ€
@jrRNAscientists
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Ignatova Lab retweeted
29 Jul 2024
The time to think and inquire are precious.
Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery.
nature.com/articles/d41586-0β¦
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25 Jul 2024
SMYD5 methylation of rpL40 links ribosomal output to gastric cancer | Nature nature.com/articles/s41586-0β¦
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Ignatova Lab retweeted
18 Jul 2024
How does one #tRNA-mimicking mascRNA from #MALAT1 get one CCA tail and is stable, while menRNA from #NEAT1 receives two marking it for decay? We uncover a #riboswitch-like mechanism where menRNA self-destructs by getting seconds.@IliasSkeparnias @NatureSMB go.nature.com/3WcOGmc
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2 Jul 2024
mRNA location and translation rate determine protein targeting to dual destinations - PubMed pubmed.ncbi.nlm.nih.gov/3750β¦
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Ignatova Lab retweeted
2 Jul 2024
Mistranslating tRNA variants have anticodon- and sex-specific impacts on Drosophila melanogaster biorxiv.org/content/10.1101/β¦
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30 Jun 2024
Discovery of antimicrobial peptides in the global microbiome with machine learning: Cell cell.com/cell/fulltext/S0092β¦
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Ignatova Lab retweeted
25 Jun 2024
Trying to engineer tRNA??? 𧬠We have a created a roadmap πΊοΈ in our newest review. Check it out ππΌππΌππΌππΌ
links.email.frontiersin.org/β¦
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