Infectious Diseases physician-scientist @UCSF| Fascinated by protein synthesis and TB. Occasional out of the box thinker. Bahá’í , father, husband. Own views.
Joined March 2020
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Jun 4
My lab used to publish in Frontiers for a number of reasons, but for the last few years I've avoided them for worsening predatory practices and don't review for them either.
Seen a few recent papers there and all/ most of the reviewers are postdocs and certainly not experts...
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Jun 4
... Not that postdocs are unable to do peer review... But it is subtly different.
Not sure it's preferable to just preprinting if I'm honest.
With the recent NIH noises about OA fees, I suspect OA only journal days may be numbered.
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Extended Shine-Dalgarno motifs govern translation initiation in Staphylococcus aureus nature.com/articles/s41467-0… 🦠
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Ribosome heterogeneity in E. coli : ribosomal RNA (rRNA) sequence and modifications, r-protein stoichiometry and PTMs, and ribosome-associated proteins pubs.acs.org/doi/10.1021/jac… 🦠
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Decoding universal principles of codon-mediated regulation of gene expression => model "codon weights" from transcriptomic data, for prediction of mRNA/prot abundance "species-specific environments for gene expression are encoded in codon weights" doi 10.64898/2026.05.27.728126v1
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May 28
Mapping the avoid-ome: a systematic open-science approach to predictive ADMET | Nature Communications share.google/rhUycDs2cuZZKzW…
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May 21
Transformative work from the @mbarnalab Ribo-Tweezer enables direct interrogation of ribosomal protein (RP) function in mature ribosomes, revealing that distinct RPs control unique translatomes and that RACK1 removal rewires translation and stem cell identity. Congrats to all!
May 21
I’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.
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May 14
Thrilled to share my @Blender video of my paper in @Nature with Maciej (with supervision of @SimoneMattei19 & @jomaa_lab) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹
Despite its name, SNOR, a newly discovered protein, is hardly asleep on the job.
EMBL researchers’ newest technologies allowed them to discover this tiny protein with a big role that awakens cells from dormancy to restart protein synthesis.
embl.org/news/science-techno…
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May 13
Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group @UVA and @simonemattei @EMBLHeidelberg
nature.com/articles/s41586-0…
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Pancreatic cancer is one of the most dire diagnoses in medicine with few available treatments. Until now, thanks to university research, including @UCSF scientists, and federal investment in science research. Read about this huge breakthrough via @nytimes nyti.ms/4wfziXs
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May 13
Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis
biorxiv.org/content/10.64898…
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Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution
nature.com/articles/s41467-0…
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Ever wondered why only inflammasomes that use ASC, but not those that do not use ASC, can mature IL-1β? ASC helps to recruit pro-IL-1β to ASC for caspase-1 processing! See: "Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation" pnas.org/doi/10.1073/pnas.25…
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May 8
We have developed a cysteine-free, highly thermostable tagging system, UTag, that enables single-mRNA translation tracking in live cells. You may wonder how different tagging systems affect translation kinetics—we addressed this by performing a systematic comparison.
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May 7
The mechanism by which macrophage cells sense danger to drive an immune response and inflammation has been elusive. A new report highlights change in cell volume as the signal @JCellBiol
rupress.org/jcb/article/225/…
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May 7
Sad to hear about Barry's recent passing. He was an amazing mentor who always advocated for jnr scientists.
Remembering public health pioneer Barry Bloom: a scientist, a mentor, a mensch statnews.com/2026/03/30/barr… via @statnews
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Ribosome collisions trigger tmRNA-mediated rescue through mRNA disengagement biorxiv.org/content/10.64898… 🦠
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In @MolecularCell: RNA polymerase, the enzyme that synthesizes RNA from DNA during transcription, has been captured mid-reaction for the first time by scientists in Seth Darst's lab at Rockefeller.
🔗: bit.ly/4ur3Vaz
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