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JCI insight @JCI_insight

High-quality basic & translational research representative of biomedical specialties & physician-scientists. Bluesky: bsky.app/profile/insight.jci…

Joined October 2016
  • Tweets 5,913
  • Following 2,433
  • Followers 39,802
3,663 Photos and videos
JCI insight retweeted
Peters Lab@lab_peters
Jun 12
Delighted that our study mapping the #proteome in #SLE is now published in @JCI_insight . Great work from the team especially grad student Geoffrey Leung insight.jci.org/articles/vie…

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JCI insight retweeted
ASCI
@the_asci
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Revealing a paradox behind the failure of #Vaccines that target #VirulenceFactors: doi.org/10.1172/jci.insight.… ASCI member George Y. Liu & team @UCSanDiego find the efficacy of vaccines against staphylococcal alpha toxin is markedly reduced in aged mice because of senescence-related loss of toxin virulence function. The figure: Evaluation of Hla as a virulence factor and vaccine target in aged mice.
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Providing a powerful model to improve future therapies for type 1 diabetes: doi.org/10.1172/jci.insight.… Remi J Creusot & team @ColumbiaMed show how the human immune system responds to transplanted stem cell-derived insulin-producing cells via assessing autologous or allogeneic grafts in humanized mice. The image shows proliferative cells in allogeneic grafts. #T1D #BetaCells
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Modeling immune responses to autologous and allogeneic human stem cell–derived islet grafts in vivo: doi.org/10.1172/jci.insight.…
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In vivo characterization of #Candida extracellular vesicles reveals unique infection pathway proteins: doi.org/10.1172/jci.insight.… In this Research Letter, David R. Andes @davidrandes & team @uwsmph describe the in vivo isolation, characterization, and relevance of fungal biofilm extracellular vesicles.
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JCI insight retweeted
Theodore S. Kapellos@KapellosTS
Jun 12
Happy to share that our work together with @SchillerLab, Scott Budinger, Ben Singer and Sasha Misharin from @NorthwesternMed is now online on @JCI_insight. A full tweetorial that summarizes the study follows! @LMU_Muenchen @HelmholtzMunich @LungHealthMUC
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JCI insight retweeted
Herbert B Schiller
@SchillerLab
Jun 12
Happy to see our study out in @JCI_insight - collaborative work with Northwestern Chicago - see a full thread by @KapellosTS below.
Theodore S. Kapellos@KapellosTS
Jun 12
Happy to share that our work together with @SchillerLab, Scott Budinger, Ben Singer and Sasha Misharin from @NorthwesternMed is now online on @JCI_insight. A full tweetorial that summarizes the study follows! @LMU_Muenchen @HelmholtzMunich @LungHealthMUC
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Heterozygous #TBX4 variants are the 2nd most common genetic cause of pediatric #PulmonaryHypertension. doi.org/10.1172/jci.insight.… Ripla Arora & team @michiganstateu establish a mouse model of TBX4 syndrome that avoids embryonic lethality via conditional Tbx4 knockout and find that excessive and ectopic muscularization of the lung may underlie pulmonary hypertension. The video shows echocardiography evidence of PH seen in adult mice, TbxcKO and Tbx4cKO;Tbx5het.
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Hypertension is a risk factor for the progression of arterial stiffness; however, the underlying mediators have remained ill-defined. doi.org/10.1172/jci.insight.… Curt D. Sigmund @curtsigmund & team @MCWPhysiology use cell and mouse models, reporting RhoBTB1 and RbFox2 as regulators of arterial stiffness through a mechanism controlled by the CUL3 E3 ubiquitin ligase that influences cytoskeletal integrity. The image shows vascular RbFox2 Expression (red) in a mouse model for hypertension and arterial stiffness. CD31 (green) indicates endothelial staining; DAPI (blue) shows nuclei. #VascularBiology
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Vascular smooth muscle RbFox2 regulates the cytoskeleton and arterial stiffness by a RhoBTB1/Cullin-3 mechanism: doi.org/10.1172/jci.insight.…
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JCI insight retweeted
Ji Zhang Lab@JiZhangLab
Jun 9
It is a great pleasure to share our recent work by Rodney Claude @ScienceGuyRod and Sankalp Srivastava @darwinpwndyou , published at JCI Insight @JCI_insight insight.jci.org/articles/vie… There are two major findings in this story.

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JCI insight retweeted
Jason Dyck@JasonRBDyck
Jun 9
Excited to highlight our newest study: JCI Insight - Semaglutide-induced loss of skeletal muscle mass is blunted by co-administration of ketone esters insight.jci.org/articles/vie… @UAlberta_FoMD
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Curing diabetes in mice without immunosuppression! doi.org/10.1172/jci.insight.… Here, Seung K. Kim & team @StanfordMed present a non-toxic conditioning regimen with very low-dose radiation that enables stable mixed hematopoietic chimerism and islet allotolerance. The image shows histology of the recovered islet graft at the experimental endpoint in mice showing minimal CD45 immune cell infiltrate; insulin (green), CD45 (magenta), and glucagon (white). #T1D
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JCI insight retweeted
ASCI
@the_asci
Jun 9
From improvised to intentional: Re-Imagining the physician-scientist career path: doi.org/10.1172/jci.insight.… ASCI member Kyu Rhee @WeillCornell with Christopher S. Williams @williams_lab @VanderbiltMSTP et al. discuss the #PhysicianScientist career at its crossroads, drawing from the 2025 ASCI/AAIM/BWF Workshop, which called for intentional investment, flexible funding, mentorship, and institutional commitment to sustain this vital workforce. @ChoateMD @KimrynRathmell @patrickhu @DrChrisPitt
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How do cancer cells remodel their endosomal system under nutrient stress? doi.org/10.1172/jci.insight.… This issue’s Cover features work by Peng et al. showing serum starvation drives extracellular vesicle biogenesis and determines tumor progression. The cover image is a colored transmission electron micrograph of a HeLa cell expressing Rab5Q79L, which induces the formation of enlarged multivesicular body–like vesicles containing multiple small intraluminal vesicle–like structures. #CancerBiology
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Serum starvation drives ALIX-dependent extracellular vesicle biogenesis and determines tumor progression
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From earlier this week: This first-in-disease study supports the use of #GLP1 agonist in pulmonary vascular disease Colm McCabe & team @RBandH show the GLP-1 agonist exenatide causes acute relaxation of lung blood vessels in pulmonary arterial hypertension: doi.org/10.1172/jci.insight.… The figure demonstrates the effects of exenatide in the rat model of pulmonary hypertension. #PAH
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Previously shared: The translational potential of #metformin in #HuntingtonsDisease is compelling: doi.org/10.1172/jci.insight.… Robert M. Friedlander & team report metformin regulates mitochondrial fission, reprograms deregulated metabolism in HD microglia, and controls microglial activation and inflammation in HD transgenic mice. The image shows traced microglial morphology from striatum of the HD mouse model R6/2 treated with Metformin.
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How do lipoproteins become trapped in the arterial wall in type 2 diabetes? doi.org/10.1172/jci.insight.… Bo Angelin & team performed a cross-sectional study in patients with #T2D and controls, finding the increased susceptibility of serum LDL particles to bind arterial proteoglycans is linked to their enhanced transvascular entrapment and ultimately atherosclerosis.
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JCI insight retweeted
Phillips’ Lab@LabPhillips
Jun 3
How does vitamin uptake influence heart disease? In our new JCI Insight paper, we show that disrupted vitamin uptake can lead to cardiomyopathy and that early supplementation can prevent progression. insight.jci.org/articles/vie… @TheBHF @SimonDBamforth @UniofNewcastle @JCI_insight
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