2. Combining L-asparaginase with ASX-173, a newly developed ASNS inhibitor, significantly delays disease progression in ASNS-high ALL models in vivo, without prohibitive toxicity.
1. Despite initial efficacy of GCN2 inhibition in sensitizing acute lymphoblastic leukemia (ALL) cells to L-asparaginase treatment, a subset of Gcn2-deficient cells express ASNS at high levels in a Gcn2-independent manner, which eventually drives therapeutic resistance.
Congratulations to Rodney Claude @ScienceGuyRod . You are officially a doctor now. I am so proud of you. I hope you will enjoy the next stage of your career journey as a PhD.
Several undergraduate students joined us @IUDeptPeds this summer for 8-week internships with our faculty and research experts, gaining hands-on experience in the world of science and medicine. Read about some of their experiences: medicine.iu.edu/blogs/pediat…
With a new $3.2M NHLBI grant to study low oxygen's benefits on blood stem cells, @IUMedSchool@IUDeptPeds scientists aim to expand the reach of advanced stem cell therapies and develop new strategies for treating a range of blood disorders. Read the news: medicine.iu.edu/news/2025/01…
The 3rd Midwest Metabolism Meeting is officially announced @LurieCancer! This exciting event is set to take place @NUFeinbergMed in Chicago on Sept 19th. All postdocs and students from the Midwest region are invited to submit their abstracts by March 1st! cancer.northwestern.edu/even…
Big congratulations to Rodney Claude @ScienceGuyRod , my 2nd graduate student, who passed his qualifying exam today. Now, you are officially a Ph.D. candidate. I am so proud of you. @IUWellsCenter@IUSM_Biochem
Online now! Asparagine restriction enhances CD8 T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response dlvr.it/StKN8j
Join us tomorrow & Thursday to hear final presentations from 40 interns from the Wells Summer Internship and Medical Physician Engineers, Scientists and Clinicians Preparatory (MPESC-Prep) programs. We can't wait to discover what they learned this summer! 🧬🔬🥼
📣 Symposium Announcement
Please join us in Ann Arbor @UMich on May 25th for a 1-day meeting on “Metabolic and Immunological Impacts on Ferroptosis and Cell Death”. See the awesome speaker line-up below. Register for FREE at link: tinyurl.com/2023CellDeathReg…
Please spread the word!
Congratulations to Sankalp Srivastava @darwinpwndyou for a solid defense today. Now, we can officially call you Dr. Srivastava. I am very proud of being your mentor. @IUWellsCenter@IUCancerCenter
Join us today for the thesis defense of Sankalp Srivastava. He will present his work on "The essential role of the non-essential amino acid asparagine in lymphoid malignancies" performed under the mentorship of Dr. Ji Zhang. 1pm, R3 C203. @IUCancerCenter@IUMedResearch
ALT Cartoon of a female scientist looking through a microscope. Accompanied by text that reads, "Wells Center 2023 Summer Internship. Hands-on experience in pediatric bench research. Undergrad students are eligible. 8-week program from June 5 to July 28, 2023. Applications close on January 21, 2023.
Ji Zhang (@JiZhang32146855), PhD, and his colleagues identify two distinct metabolic subclasses among neoplastic populations within individual human and mouse tumors and what it means for pancreatic cancer in @NatureCancer. Learn more: ow.ly/3CKA50LRk7H.
ALT Cartoon of a female scientist looking through a microscope. Accompanied by text that reads, "Wells Center 2023 Summer Internship. Hands-on experience in pediatric bench research. Undergrad students are eligible. 8-week program from June 5 to July 28, 2023. Applications close on January 21, 2023.
Sophia joined our Summer Internship Program and had a great experience! If you're like Sophia and want to gain hands-on experience in pediatric research, now's your time to apply for our 2023 program. Applications are open for undergrads until Jan. 21: medicine.iu.edu/research-cen…