Joined June 2012
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🧵(1/7) Proud that our new study is finally out after years of work! šŸŽ‰ Did you know even short-term #sleep loss šŸ’¤ can result in a molecular fingerprint linked to increased future #cardiovascular disease risk? šŸ«€ ā¤ļøā€šŸ©¹ biomarkerres.biomedcentral.c… Also timing & #exercise šŸƒā€ā™‚ļø matter ->
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Tips for how to not wreck your #sleep and still be able to enjoy the World cup soccer games from European time zones @SvD svd.se/a/ArEXBj/somnforskare…
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Online now!✨Iiams, Skinner et al explore the effect of early-onset, lifelong time-restricted feeding in >500 male and female mice, and report extended healthspan in male and female mice, and extended lifespan in male mice @SamIiamsClever @CircadianClocks nature.com/articles/s43587-0…
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A study published last month in #JBR shows that humans exhibit seasonal changes in sleep, oxygen levels, and respiratory indices. Environmental rhythms and human biology are tightly linked! journals.sagepub.com/doi/10.…
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In a randomized trial of a PCSK9 inhibitor [for LDL cholesterol lowering] vs placebo for patients with diabetes and no known heart disease, there was significant reduction of major cardiovascular events including deaths #ACC26 @JAMA_current jamanetwork.com/journals/jam…
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Our collaboration with Dr. Lisa Chow and her team found that TRE (without dietary advice) produced similar outcomes in food and nutrient intake as instructed caloric restriction. sciencedirect.com/science/ar…

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Joseph T. Bass, MD, PhD, joins the Mind & Matter podcast with Host Nick Jikomes to discuss circadian clock mutations and disruptions, hormone rhythms, and weight management. Listen to the full episode: rss.buzzsprout.com/1535644.r…
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Our new study in @NatureComms with Applied Cognition used computational PK modeling and a 2‑site crossover clinical study to show that during sleep, glymphatic clearance - not synaptic release - drives overnight changes in plasma Aβ and tau in people. nature.com/articles/s41467-0…
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Thank you to Drs @JCedernaes, Bettina Sielaff & Christian Benedict for an aptly named and excellently written Editorial summarizing and contextualizing the study: Time to regularize sleep regularity academic.oup.com/sleep/advan…
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The Sleep Regularity Index (SRI) is a strong predictor of health & disease In SLEEP, we report: āž¤šŸ“ˆSRI use āž¤>50% non-disclosure of SRI methods āž¤Two calculators produced discrepant SRIs Introducing the Reporting Items for Regularity Indices (RIRI)🧵 academic.oup.com/sleep/advan…
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Congratulations Joe, @JoeBass91471540!! Incredibly well deserved - you're such an amazing scientist, inspiration and mentor. This is a great recognition for all the pioneering work that Dr. Bass has done in the field of #circadian biology, metabolism and endocrinology.
We are delighted to celebrate the election of our esteemed colleague, Dr. Joe Bass, @JoeBass91471540 to the @theNAMedicine. This honor recognizes his outstanding contributions to the field of Endocrinology, Metabolism, and Molecular Medicine, and his pioneering research elucidating the critical links between the body’s circadian rhythms and metabolic regulation. Dr. Bass’s groundbreaking work has revealed how disruptions in the circadian system contribute to metabolic diseases such as diabetes and obesity. This election represents a well-deserved and long-overdue recognition of Dr. Bass’s exceptional scientific achievements and his profound impact on the field. Congratulations, Joe, on this remarkable and richly merited honor. @NU_BMG_SQE @NUFeinbergMed @theNASciences
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Jonathan Cedernaes retweeted
We are delighted to celebrate the election of our esteemed colleague, Dr. Joe Bass, @JoeBass91471540 to the @theNAMedicine. This honor recognizes his outstanding contributions to the field of Endocrinology, Metabolism, and Molecular Medicine, and his pioneering research elucidating the critical links between the body’s circadian rhythms and metabolic regulation. Dr. Bass’s groundbreaking work has revealed how disruptions in the circadian system contribute to metabolic diseases such as diabetes and obesity. This election represents a well-deserved and long-overdue recognition of Dr. Bass’s exceptional scientific achievements and his profound impact on the field. Congratulations, Joe, on this remarkable and richly merited honor. @NU_BMG_SQE @NUFeinbergMed @theNASciences
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Light at night and heart disease! Published today in JAMA Network Open. We found that those with the brightest nights had higher risks of coronary artery disease, myocardial infarction, heart failure, atrial fibrillation, and stroke. jamanetwork.com/journals/jam…
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This is great news for the U.S.! While we support abolishment of the biannual switching of the clocks, permanent Standard Time is the better option for our sleep😓, health āš•ļø, and even for the safety of our children on the way to school in the mornings šŸš
🚨Just in: A Senate bill to make Daylight Savings Time permanent in the U.S. has failed today
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Thanks for sharing my invited commentary @CircadianClocks šŸ™ Regarding the new study by Windred et al on how greater objective #light exposure at night is associated with increased risk of #cardiovascular disease (n~89000, 8 yrs follow up) #sleep #myocardialinfarction #stroke
Illuminating the Risks of Nighttime Light for Cardiovascular Health jamanetwork.com/journals/jam…
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The evidence for these is quite weak: - #melatonin: minor sleep effect, (<8 min.) but ā¬†ļø quality , *actually* a #circadian hormone -substandard for recommending magnesium clinically -no objective (conflicted with subjective) improvements from theanine -lack of support for others
One of the most common things I'm asked about is sleep supplements. Here's my list (and why I take them): • Melatonin - 3 mg or less 1-3 hours before bed. Best reserved for travel/jet lag or when you *really* need sleep. • Magnesium glycinate - calms the nervous system especially when stressed (which depletes magnesium). I take 120 mg before bed but some research uses 200-400 mg. • L-theanine - non-sedating amino acid that helps to calm the brain. A dose of 200-400 mg can improve sleep latency and sleep quality, especially if you're dealing with anxiety/insomnia. • Glycine - when taken about 30-60 minutes before bed, it may improve subjective sleep quality due to its nervous system effects. • Myo-inositol - not strongly evidenced as a sleep aid but I've found it helps me calm the "mental chatter" before bed.
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Think babies are born without a body clock? ā° Not true! By the time they’re born, infants already have a working circadian system that responds to light. Here’s the timeline of how their internal clock develops before birth šŸ‘‡@LauraKervezee frontiersin.org/journals/neu…
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25 Aug 2025
How can we reduce the risk of Type 2 diabetes by 31% A randomized trial of the Mediterranean (MED) diet, weight loss (avg 7 lbs) and moderate exercise vs the MED diet alone acpjournals.org/doi/full/10.…
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I support this message! The goofy ā€œbiological ageā€ tests are largely just a scam perpetuated by those that sell the tests and then subsequent supplements based on the stupid tests
meaningful health outcomes are things like walking speed, endurance, recovery from cuts and scrapes when you have biomarkers that outperform functional test, let us know
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Today in 1945, George Orwell published a devastating critique of Communism. Animal Farm reveals why every communist revolution follows the same tragic pattern: liberation to corruption to oppression. Here are 10 truths from Animal Farm Orwell warned us never to forget šŸ§µšŸ‘‡šŸ¼
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