News from the John Gross Lab at @UCSF. We study the structural biology of proteins involved in RNA metabolism and HIV infection.
Joined September 2016
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41 Photos and videos
John Gross Lab retweeted
12 Oct 2024
UCSF Department of Pharmaceutical Chemistry is hiring faculty! Seeking candidates in #chemicalbiology, #computationalchemistry, #AI, #drugdiscovery and more. Apply now! aprecruit.ucsf.edu/JPF05273
#UCSF #QBI #FacultyJobs #academicjobs #UCSFPharmacy
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9 Sep 2024
End of summer, chocolate cake, and birthday celebrations.
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18 Dec 2023
Congratulations to Victor Lam who defended his thesis on how 'SIV/HIV-1 Vif overcomes host defenses with one small trick'
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10 Aug 2023
Interested in enzyme regulation in biological condensates? Want to live the California Dream? If yes, and yes, consider applying to our lab!
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8 Feb 2023
Congratulations to post-doc Yen-Li Li for her work on the structure of HIV-1 Vif in complex with human A3G. A fantastic collaboration with @__caro__line___ , @nchesarino, @memerman of #FredHutch and @ig_ech, @caleighmazumaya, @yifan_ucsf of #UCSF. rdcu.be/c5bst
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18 Jan 2023
Check out this review article by former graduate student Ryan Tibble dedicated to Gerhard Wagner for his 75th Birthday on the challenges and opportunities for NMR spectroscopy in biological condensates. authors.elsevier.com/sd/arti…
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22 Sep 2022
We are grateful for post-docs Xi Liu @XiLiu8 and Yen-Li Li as they tackle challenging problems in host-pathogen interactions and help train the next generation of scientists in our lab. #NPAW22 #ucsfNPAW #UCSFpostdocs
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5 May 2022
Thank you @SC_in_lab and Vincent Maciej for the Preview of @JPbiochemist work that was published in Structure.
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15 Apr 2022
Congratulations @JPbiochemist , beautiful biochemical and structural studies of the Pox Virus mRNA decapping enzyme D9 with @JemielityLab!
doi.org/10.1016/j.str.2022.0…
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11 Dec 2021
Celebrating Dr. Ryan Tibble's thesis research today, prompting us to think deeply about how phase separation regulates enzyme activity.
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6 Oct 2021
SO to @JPbiochemist
for beautiful work on structure and mechanism of pox virus decapping enzyme D9 biorxiv.org/content/10.1101/… with fantastic cap analog chemistry from
@JemielityLab.
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16 Jun 2021
Congratulations to lab member Leandrew Dailey who just passed his qualifying exam! Great day to celebrate with Detroit Pizza and cake from Hahdough.
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John Gross Lab retweeted
28 Mar 2021
Phase-separated Edc3 Condensates amplify m7G-RNA Decapping!
Dcp1/2 Enzymes partition into Edc3 Droplets & are catalytically activated.
Using a Fluorescein-m7G Conjugate to study P-body Enzyme Kinetics.
By Ryan Tibble &
@JDGrossLab.
Now in:
nature.com/articles/s41589-0…
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10 Jul 2020
Check out preprint by graduate student Ryan Tibble showing how conformational control of mRNA decapping is coupled to the formation of biological condensates. Fantastic collaboration with @Jacek93345390 lab at Univ of Warsaw CeNT.
biorxiv.org/content/10.1101/…
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2 Jul 2020
Congratulations to Joe Lobel for recent publication on how the mRNA decay factor Pat1 increases range of RNA substrates bound by the Lsm1-7 complex! Wishing Joe best of luck as he departs for work with @nickingolia. rnajournal.cshlp.org/content…
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2 Jul 2020
And see companion paper with structural work by @SamuelEButcher and colleagues suggesting a gated mechanism for Lsm1-7 access to internal RNA binding sites. Both studies point to Pat1 as the gatekeeper!
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John Gross Lab retweeted
12 Dec 2019
Check out our recent publication from the @JDGrossLab and @memerman lab. @nchesarino and I teamed up on this project describing the SIVrcm Vif structure and adaptations that allowed this Vif to antagonize human A3G. sciencedirect.com/science/ar…
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5 Nov 2019
Congratulations to graduate student Joe Lobel for recent publication showing how intrinsically disordered regions of the scaffolding protein Pat1 contribute to mRNA decay! pnas.org/content/early/2019/…
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25 Oct 2019
Celebrating recent publications and good health at Thee Parkside SF.
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