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David Kuster @RNADavid

RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. Phase separation, Aptamers & RNA fun @HymanLab. And birds @Birder_David.

Joined June 2017
  • Tweets 1,133
  • Following 1,830
  • Followers 1,516
121 Photos and videos
RT @ShorterLab: Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: science.org/doi/10.1126/scie…

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how...

science.org
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David Kuster retweeted
Kazuhiro Maeshima@kazu_maeshima
Apr 10
Our linker histone H1 paper is featured on the cover of the April 10 issue of @ScienceAdvances. science.org/doi/10.1126/scia… A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: science.org/toc/sciadv/12/15
Kazuhiro Maeshima@kazu_maeshima
Apr 8
Our linker histone H1 paper is out @ScienceAdvances: science.org/doi/10.1126/scia… @MasaAShimazoe et al. reveal that H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo, @janhuemar, Charlie Phillips and others—huge thanks! 🙌 ½
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David Morales-Álamo@D_Morales_Alamo
Apr 3
New research shows “pearling” — a constriction of mitochondria — drives distribution of mitochondrial DNA nucleoids, helping ensure proper genetic organization and inheritance within cells. 🧬 science.org/doi/10.1126/scie…

Pearling drives mitochondrial DNA nucleoid distribution

The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their...

science.org
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Nature Chemical Biology@nchembio
Apr 1
The Focus issue features views from redox biologists on the next frontiers and most needed developments in the field nature.com/articles/s41589-0… Free to read link: rdcu.be/fbdwd
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ShorterLab@ShorterLab
Mar 25
A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms: journals.plos.org/plosbiolog…

A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic...

TDP-43 pathology is a hallmark of several neurodegenerative disorders, but the connection between TDP-43 aggregation and dysfunction remains poorly understood. This study develops a quantitative...

journals.plos.org
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Pombo-GarciaLab@karina_pombo
Feb 20
We are hiring a research assistant for the lab! Come join us if you are excited about cell cell interactions in the gut, genetics and imaging!  Deadline: 15 th March Apply here  nature.com/naturecareers/job… #oxford #Hiring #pombogarcialab

Research Assistant (10390) - Harwell, Didcot

The Rosalind Franklin Institute (the Franklin) is a technology institute established by the UK Government as a unique centre committed to advancing...

nature.com
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Kazuhiro Maeshima@kazu_maeshima
Feb 10
My student @Aoi_Otsuka_’s PhD work is now officially published @CSF_JSCB! 🔬Single-nucleosome imaging uncovers biphasic local chromatin dynamics in an oncogene-inducible human carcinogenesis model (1–3 d: same, 5–7 d: ↑, back by week 4). Congrats! 👏 jstage.jst.go.jp/article/csf…
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Bede Portz@YSPTSPS
Feb 4
nature.com/articles/s41467-0…

The role of low-complexity repeats in RNA–RNA interactions and a deep learning framework for duplex...

Nature Communications - Interactions between long RNA molecules play essential roles in shaping gene regulation. Here, the authors show that low-complexity repeats drive stable contacts between...

nature.com
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News from Science
@NewsfromScience
Jan 15
The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles. Learn more: scim.ag/3NKZXJQ
Two panel graphic showing new method for tracking gene activity.

ALT Two panel graphic showing new method for tracking gene activity.

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ShorterLab@ShorterLab
Jan 15
Organelle biogenesis on a synthetic bead: biorxiv.org/content/10.64898…

Organelle biogenesis on a synthetic bead

Centrosomes are complex organelles that comprise multiple copies of hundreds of different proteins, yet they can precisely duplicate every cell cycle. Here we reconstitute centrosome duplication on...

biorxiv.org
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David Kuster retweeted
Rothstein Lab@Rothstein_Lab
Jan 15
TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues biorxiv.org/content/10.64898…

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons,...

TDP-43 is an RNA and DNA binding protein that plays major roles in regulating RNA processing. In particular, TDP-43 dysfunction leads to the accumulation of cryptic splice isoforms that result from...

biorxiv.org
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Science Magazine
@ScienceMagazine
12 Dec 2025
Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure. Learn more in a new #SciencePerspective: scim.ag/48FsaIR
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ShorterLab@ShorterLab
28 Nov 2025
Proximal proteomics reveals a landscape of human nuclear condensates: nature.com/articles/s41556-0…

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Ugo Kelvin Ihenacho@Absolutenivlek
2 Nov 2023
Pleased to announce that my PhD thesis work in @Blake_Hill_Lab on structural mechanisms governing vertebrate FIS1 function is finally out in JBC. sciencedirect.com/science/ar… 🧵a thread

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Ugo Kelvin Ihenacho@Absolutenivlek
30 Oct 2025
🛡️”The Iron Dome”🛡️ Under alcohol stress, a slime mold rapidly retracts into a sclerotia of thousands of hexagonal spherules, sealing so tightly that Dextran-FITC (cyan) can’t enter. Captured by me at the MBL Physiology Course (Gladfelter Lab rotation). #MBL #Microscopy
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Ugo Kelvin Ihenacho@Absolutenivlek
30 Oct 2025
Replying to @RNADavid
@RNADavid 👀
ShorterLab@ShorterLab
30 Oct 2025
Selective RNA sequestration in biomolecular condensates directs cell fate transitions: nature.com/articles/s41587-0…
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ShorterLab@ShorterLab
30 Oct 2025
Selective RNA sequestration in biomolecular condensates directs cell fate transitions: nature.com/articles/s41587-0…

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Nature Biotechnology - Stem cell differentiation is controlled by manipulating RNA condensates.

nature.com
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Barak Raveh@BarakRaveh
18 Oct 2025
Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of nucleocytoplasmic transport: pnas.org/doi/10.1073/pnas.25…

Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic...

Nuclear pore complexes (NPCs) enable rapid, selective, and robust nucleocytoplasmic transport. To explain how transport emerges from the system com...

pnas.org
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ShorterLab@ShorterLab
16 Oct 2025
Nucleic acid-protein condensates in innate immunity: Molecular Cell cell.com/molecular-cell/full…

Nucleic acid-protein condensates in innate immunity

This review highlights work describing nucleic acid-protein co-condensates that form or accumulate upon activation of innate immune pathways in mammalian cells. Areas of discussion include insights...

cell.com
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brangwynnelab@brangwynnelab
20 Sep 2025
A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @VirusesImmunity. princeton.edu/news/2025/09/1… #KeioMedicalSciencePrize

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize

Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell...

princeton.edu
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