A Taiwanese in Chicago 👨🔬📯🌈｜#TeamMassSpec @NLKProteomics | Find me @jfhorner.bsky.social
Joined June 2013
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18 Photos and videos
I will be presenting at Consortium for Top-Down Proteomics’s Proteoform Thursday Webinar Series. The catenin phospho-code work laid the foundation for my future research group. Free register link below!
Join us March 26 for Proteoform Thursday: Jeffrey Huang presents - "A Catenin Phospho-Code for Adherens Junction Organization"
us06web.zoom.us/meeting/regi… #proteomics #massspec
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I am thrilled to share that I will be joining @TAMUChemistry as a tenure-track Assistant Professor this summer. My research group will advance top-down mass spectrometry and proteomics to study the proteoform biology of cell–cell adhesion and phosphorylation in disease.
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This transition also marks the close of more than 10 years at Northwestern as a PhD student and postdoc. I am deeply grateful to my mentors, @NLKProteomics, @GottardiLab, and @MrksichGroup, whose guidance and support shaped both my scientific thinking and my career path.
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You can learn more about my research here:
artsci.tamu.edu/chemistry/co…
Our group website will be launching this summer. Check back then!
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21 Nov 2025
It was a great pleasure attending my first #HUPO world congress in Toronto last week and sharing our catenin phospho-code story! It was inspiring meeting with peers and pioneers in the field, which reminded me how special the proteomics community is!
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21 Nov 2025
I want to thank @us_hupo for the Travel Award that made this trip possible; and @AFFINISEP for the generous and supportive seminar invitation.
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21 Nov 2025
It was a great pleasure attending my first #HUPO world congress in Toronto last week and sharing our catenin phospho-code story! It was inspiring meeting with peers and pioneers in the field, which reminded me how special the proteomics community is!
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Che-Fan Jeffrey Huang retweeted
3 Nov 2025
The @NLKProteomics team, in collaboration with @GottardiLab, applies individual ion mass spectrometry to characterize LARGE intact catenin proteoforms — led by postdoc @JFhorner. #openaccess 🔓 onlinelibrary.wiley.com/doi/…
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31 Oct 2025
THRILLED to share our new publication in @angew_chem from @CLP_Institute @NU_CDB “Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85–110 kDa) Regulated by Actomyosin Contractility” using TDMS to study LARGE catenin proteoforms. (1/7)
doi.org/10.1002/anie.2025185…
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31 Oct 2025
BIOLOGY TAKEAWAY: We proposed a catenin phospho-code—where combinatorial phosphorylation of these large proteoforms works with mechanical signals to drive cadherin–catenin organization and #adherensjunction function. (6/7)
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31 Oct 2025
TECHNICAL INNOVATION: We demonstrated that I2MS for fragment ion analysis (I2MS2) increases catenin top-down sequence coverages from <1% to ~30%. We expect future instrumentation advances will improve proteoform-level analysis of these LARGE structural proteins/complexes. (7/7)
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27 Oct 2025
Heading to #HUPO2025! I’ll talk about our catenin phospho-code story and how top-down MS reveals how adhesion proteins respond to actomyosin force!
Thanks for the invite, @AFFINISEP!
Full story on bioRxiv 👉 doi.org/10.1101/2025.09.06.6…
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Che-Fan Jeffrey Huang retweeted
8 May 2025
Come join us at NMO's Spring 2025 Concert TOMORROW at 7:30pm in Thorne Auditorium! Register with the QR code below or through the link in our Instagram bio!
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Che-Fan Jeffrey Huang retweeted
17 Apr 2025
Phuong Le, @j_quinn_edu , @JFhorner @GottardiLab & co show that the adhesion protein α-catenin has a key modification that allows dividing cells to stay better connected to their neighbours, helping the tissue stick together during mechanical stress. doi.org/10.1242/bio.061726
ALT The phosphorylated form of α-catenin localizes to the apical portion of adherens junctions. The image shows 3D surface rendering using Imaris software of a confocal image of a dividing kidney epithelial cell line (Madin–Darby canine kidney or MDCK cells). Phosphorylated α-catenin is shown in magenta and adherens junctions are in green. The phosphorylated form of α-catenin localizes to the apical portion of adherens junctions. The image shows 3D surface rendering using Imaris software of a confocal image of a dividing kidney epithelial cell line (Madin–Darby canine kidney or MDCK cells). Phosphorylated α-catenin is shown in magenta and adherens junctions are in green.
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11 Apr 2025
The mass spectrometry research community at Chicago is thriving! Many thanks to the Chicago Mass Spec Interest Group for the invitation to share my catenin proteoform story in the inaugural event. It was a pleasure to meet with researchers at the beautiful CZbiohub space!
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