Excited to share our latest work published today in @SciImmunology and featured on the cover! This study demonstrates that thrombospondin-1 (Thbs1) is a driver of hematopoietic aging and that targeting Thbs1 suppresses inflammaging and restores systemic and HSC healthspan.
Science #Immunology's January issue is out!
This month's cover depicts how deleting #thrombospondin1 can reverse aging-associated defects known as #inflammaging in hematopoietic stem cells in mice.
Read this research and more: scim.ag/3BI2A9Z
This was a long time coming and was spearheaded by the amazing @pradeepvpr! Congratulations to Pradeep and all our talented crew that helped us along the way. Thank you to @ClaireOlingy and all the reviewers for making this a great experience.
In summary, this study defines NTN1 as critical growth factor that regulates aging of the BM niche, and describes a novel role for NTN1 in reactivating DDR within aged BM vascular cells, mesenchymal stem cells and HSCs.
We would like to thank the Editors at @NatureComms for making this process painless and smooth. As well as our reviewers, particular @ChuteLab, for their constructive comments. Your suggestions most definitely improved the manuscript.
Excited to announce the lab has moved to @UFMedicine@ufhealthcancer. Equally excited for my new role as Vice Chief of Research in Hem/Onc. Many thanks to @DrMarkham & @jdlicht for this wonderful opportunity. Looking forward to working with this amazing scientific community!
Though it feels great to be back home, I will forever miss NYC. The past 16yrs have been spectacular. Thank you to all my past lab colleagues and thank you to my current lab mates continuing this journey with me and those starting new adventures!
I'm also so proud of everything we accomplished as one of the founding labs at the Center for Discovery and Innovation @HMHNewJersey. I want to thank everyone for making my time there special. Looking forward to all the great things the CDI will accomplish in the coming years.
So delighted to welcome an exceptional physician-scientist, science 🧬 #Vascularbiology pioneer & good friend to AAP - Shahin Rafii @Cornell (who needs to get on twitter!)
Check out our new paper in Development! Vascular endothelial growth factor-c regulates hematopoietic stem cell fate in the dorsal aorta | Development | The Company of Biologists journals.biologists.com/dev/…
Check it out! Our very own @anu_res Anurag Maganti was 1 of 26 med students across the country to receive the 2021 @ASH_hematology HONORS (Hematology Opportunities for the Next Generation of Research Scientists) Award here at the @HMHSchoolofMed and CDI! tinyurl.com/xhv3628r
NY has given $116 billion more to the federal government than we received since 2015.
Kentucky *took* $148 billion more from the federal government than it gave.
Just give NY our money back, Senator McConnell.
NEW—Endothelial cell infection and endotheliitis in #COVID19. Correspondence from Z Varga, A Flammer, P Steiger, et al
"Here we demonstrate endothelial cell involvement across vascular beds of different organs in a series of patients with COVID-19" hubs.ly/H0pCwhx0