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Jackson Lab @ USU @Jackson_Lab_USU
Joined July 2016
  • Tweets 215
  • Following 224
  • Followers 414
6 Photos and videos
If you didn't catch our previous Nature paper showing how Cas12a2 can selectively kill cells: nature.com/articles/s41586-0…, you have another chance to see this CRISPR enzyme in action, with work we did in collaboration with the Jennifer Doudna Lab: nature.com/articles/s41586-0…

RNA-triggered cell killing with CRISPR–Cas12a2

Nature - Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression,...

nature.com
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A more technical video describing Cas12a2 Cas12a2 video, via @EurekAlert! @UofUHealth eurekalert.org/multimedia/11…

Cas12a2 video

Cas12a2 destroys a cell's DNA when activated, leading to many potential useful medical applications.

eurekalert.org
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Happy to share that our work on Cas12a2 was published in Nature last week. USU Biochemists Show CRISPR Can Selectively Destroy Cells, a Cancer-Treatment Goal usu.edu/today/story/usu-bioc…

USU Biochemists Show CRISPR Can Selectively Destroy Cells, a Cancer-Treatment Goal

Kadin Crosby, Ryan Jackson and colleagues report newly discovered details demonstrating how CRISPR Cas12a2 can be repurposed to discriminately kill cancer cells in the petri dish and in mice.

usu.edu
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Jackson Lab @ USU retweeted
CRISPR2026@crisprmeeting
Mar 1
Early registration for the CRISPR 2026 meeting is extended until March 15, 2026. The Abstract deadline is March 31, 2026. Registration is required before submitting an abstract. web.cvent.com/event/ac20b6f2…

Summary - CRISPR2026

web.cvent.com
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Jackson Lab @ USU retweeted
CRISPR2026@crisprmeeting
Feb 20
Early-bird registration discounts for CRISPR 2026 expire Feb 28. CRISPR 2026, held at Yale University, June 10 - 12, is the continuation of the original CRISPR meeting established in 2008. Register here: web.cvent.com/event/ac20b6f2….
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Jackson Lab @ USU retweeted
CRISPR2026@crisprmeeting
Feb 2
Registration for CRISPR 2026 is now open: web.cvent.com/event/ac20b6f2…. Early-bird price discounts are available until the end of February.

Personal Information - CRISPR2026

web.cvent.com
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Here is another link to the Nature article that should work for everyone. The other one was a link to the USU library. nature.com/articles/s41586-0…

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity

Nature - Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to...

nature.com
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Proud to report our collaborative work on a newly discovered CRISPR system, Cas12a3, published online in Nature today. www-nature-com.dist.lib.usu.… helmholtz-hzi.de/en/media-ce… usu.edu/today/story/usu-chem…
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We hosted a successful STEM experience for 7th and 8th graders this week. ksl.com/article/51342704/ste…

STEM camp focuses on teens who may be first-generation college grads

A science-focused camp at Utah State University is working to help kids who may be the first members in their families to go to college have an interest in higher education.

ksl.com
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Jackson Lab @ USU retweeted
Joseph E. Peters@JoePetersLab
6 Mar 2025
Our preprint is now published science.org/doi/10.1126/scie…

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric...

science.org
Joseph E. Peters@JoePetersLab
15 Nov 2024
Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear genomes. We identified several families of independently evolved telomeric transposons. 1/7 biorxiv.org/content/10.1101/…
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Jackson Lab @ USU retweeted
Kepecs Lab@KepecsLab
6 Mar 2025
Another HUGE cancer breakthrough! Daily low-dose aspirin cuts the risk of cancer spreading (metastasis) by ~55% overall, and by an incredible 74% for colorectal cancer! This study shows why: it leashes T-cells so the immune system fights it. Cheap, safe, could change cancer care!
Roychoudhuri Lab@RoychoudhuriLab
5 Mar 2025
Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
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Jackson Lab @ USU retweeted
Thomson Hallmark, PhD@tjHallmark
6 Mar 2025
An awesome PhD opportunity in the Swarts lab!
This tweet is unavailable
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Jackson Lab @ USU retweeted
Daan C. Swarts@DCSwarts
6 Jan 2025
🔥New paper! 🔥 Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems (cell.com/cell-reports/fullte…) It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...
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Jackson Lab @ USU retweeted
Daan C. Swarts@DCSwarts
7 Jan 2025
🚨New review🚨 Evolution and ecology of anti-defence systems in phages and plasmids Link: cell.com/current-biology/ful…
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Jackson Lab @ USU retweeted
David Taylor@davidwtaylorjr
7 Jan 2025
Check out our new work @NatureComms by awesome grad student Rodrigo Fregoso Ocampo and former postdoc @jpkbravo @TexasScience @ut_mbs! Guide RNA folds into gnarly geometry to tether tiny protein domains together. Great to collaborate with @metagenomi! nature.com/articles/s41467-0…

DNA targeting by compact Cas9d and its resurrected ancestor

Nature Communications - Ocampo et al. present several structures and the biochemical characterization of a compact Cas9 nuclease, shedding light on how these enzymes function and evolve.

nature.com
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Wondering which of Cas12a2's three collateral substrates it prefers to cleave? Work by Thom Hallmark @tjHallmark , Sobita Kunwar, and several others, including Sudeshna Manna from the Beisel Lab @BeiselLab answer this question: biorxiv.org/content/10.1101/…

RNA-triggered CRISPR-Cas12a2 Preferentially and Cooperatively Cleaves Collateral DNA

CRISPR-Cas systems often rely on collateral cleavage activities against nucleic-acid substrates to combat recognized mobile genetic elements. Of the associated RNA-guided Cas effector nucleases,...

biorxiv.org
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Jackson Lab @ USU retweeted
Das Lab@RDasLab
13 Dec 2024
Never seen RNA structures like these before. Congrats to @RachaelKretsch and rest of team biorxiv.org/content/10.1101/…

Naturally ornate RNA-only complexes revealed by cryo-EM

Myriad families of natural RNAs have been proposed, but not yet experimentally shown, to form biologically important structures. Here we report three-dimensional structures of three large ornate...

biorxiv.org
Rachael Kretsch@RachaelKretsch
13 Dec 2024
We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024.12.08.6… Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, @RDasLab @chiulab
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Jackson Lab @ USU retweeted
Alivia Jolley@alivia_jolley
29 Jun 2024
Proud to announce my graduation from @UStateScience with a B.S. in Biochemistry! Next stop: grad school at @utahbioscience !!!! Huge thanks to my mentor Ryan Jackson @Jackson_Lab_USU for his invaluable guidance. Excited for the journey ahead!
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Jackson Lab @ USU retweeted
Thomson Hallmark, PhD@tjHallmark
12 Jul 2024
Successfully defended my dissertation today @USUAggies. Officially #PhDone 🎉! Thanks @Jackson_Lab_USU for all the awesome experiences.
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Jackson Lab @ USU retweeted
Peter Fineran@PeterFineran
16 Jul 2024
Replying to @VoM_2024
@VoM_2024 anyone interested in a job as an assistant research fellow to work on #phages in my lab? Deadline is this Sunday. Come talk with me if interested or follow the link below.
Peter Fineran@PeterFineran
2 Jul 2024
We are looking for an Assistant Research Fellow to join the group and work on #phages as part of our @MBIEsci funded work. You must have right to live and work in NZ to be eligible. Details below otago.taleo.net/careersectio… please share
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