Neurologist / Researcher, helped catch "The Memory Thief" (opioid-associated amnestic syndrome)/ Enthusiast of a good case report and the New York Yankees
Joined July 2021
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Pinned Tweet
20 May 2025
đź“Ł New article alert! đź“Ł
Great to work with Feng Sha @AndrewKofke et al exploring assoc betw regular opioid exposure, MRI brain volumetrics, and dementia outcomes đź§
@alzdemjournals 🔓
1/brief 🧵
alz-journals.onlinelibrary.w…
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Jed Barash retweeted
NEWS: Opioid addiction linked to increased risk of dementia
The study lead by @Oxford_NDPH and @OxPsychiatry finds opioid addiction raises dementia risk by 56% compared with non‑users.
medsci.ox.ac.uk/news/opioid-…
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May 10
“…findings together support Baló-like leukoencephalopathy likely triggered or exacerbated by chronic cocaine exposure…The temporal and geographic proximity of these cases… raises the possibility of a shared toxic exposure.”
@GreenJournal
neurology.org/doi/10.1212/WN…
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Mar 28
Opioid-assoc hippocampal injury has become a staple of the @AANmember annual meeting abstracts
Here is an interesting case report from @TuftsMedSchool — including neuropath!
@joshuaak @SharanyaRamakr2 @SomaSen79612182 @schwetyk_md_phd @AndrewKofke
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Mar 20
After reviewer #1 and just before reviewer #2…
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Jed Barash retweeted
A radiologist finally makes an appearance in the Pitt but gets one-upped by the med student going into psych who has never taken a radiology clerkship 🥲
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Mar 1
Appreciate raising awareness of opioid-associated hippocampal injury, but
this report appears to represent evolution of CHANTER; opioid-associated amnestic syndrome (OAS) is an acute syndrome on the same spectrum — not CHANTER remnants
@francisdeng
sciencedirect.com/science/ar…
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Jed Barash retweeted
Feb 12
That’s why it’s so important to screen people for fentanyl, cognition, in the ED and consider MRI early to ensure these patients get the right help in a timely manner.
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Jan 31
Interesting new study (open access) đź§
Among sample of 205 patients presenting to ED for a suspected or confirmed fentanyl-related OD, 20 % of patients had amnesia or memory loss
@AODtxWorks @MHtxWorks @NpsychLiv @AndrewKofke @WVURNI
sciencedirect.com/science/ar…
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Jed Barash retweeted
Jan 20
Consistent w ample preclinical evidence of opioid neurotoxicity in the limbic system UPenn researchers report hippocampus injury in humans w oud
Jan 20
New article out of UPenn in Addiction Neuroscience đź‘€
Those w OUD had lower hippocampal volume but no evidence of brain tau deposition, compared to healthy controls (HCs)

@CorindeW @AstridPRamos @sandhitsu @NIDAnews @henrykranzler @AndrewKofke
sciencedirect.com/science/ar… (🔓)
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Jan 20
New article out of UPenn in Addiction Neuroscience đź‘€
Those w OUD had lower hippocampal volume but no evidence of brain tau deposition, compared to healthy controls (HCs)

@CorindeW @AstridPRamos @sandhitsu @NIDAnews @henrykranzler @AndrewKofke
sciencedirect.com/science/ar… (🔓)
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Jan 11
Looks like a relevant read
“Neuroimaging Patterns of Recreational Drug Use in the Emergency Setting”
@radiology_rsna
@UNC_SOM @UNCRadiology
pubs.rsna.org/doi/abs/10.114…
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14 Dec 2025
“Chasing the New Dragon
Toxic Spongiform Leukoencephalopathy With Chronic Fentanyl Inhalation”
neurology.org/doi/10.1212/WN…
@unmc
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24 Nov 2025
Would like to see a similar MCI trial for naltrexone, which has a clearer potential mechanism(s) including CNS penetrance, longer clinical experience, is more scalable based on cost
17 Nov 2025
Forecasting $NVO's EVOKE/EVOKE semaglutide in early-stage Alzheimer Disease trial results
aditharun.com/p/semaglutide-…
Open to discussion, please share thoughts and comments.
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25 Oct 2025
Interesting story on complications associated with surviving opioid overdose — including mention of hippocampal injury — by @erikafry in @guardian
theguardian.com/society/ng-i…
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13 Oct 2025
RT @PracticalNeurol: 🧠Fentanyl misuse can cause CHANTER syndrome: Cerebellar, hippocampal and basal nuclei transient oedema with restrict…
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13 Oct 2025
Credit to @PracticalNeuro for raising awareness
11 Oct 2025
🧠Fentanyl misuse can cause CHANTER syndrome: Cerebellar, hippocampal and basal nuclei transient oedema with restricted diffusion.
There’s a characteristic MRI pattern: restricted diffusion in the basal ganglia and hippocampi, with cerebellar oedema and haemorrhage.
đź“– Open access: pn.bmj.com/content/25/5/411
#neuroimaging #toxicology #neurology #OpenAccess #MedEd #neurotwitter
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1 Oct 2025
Was honored to be at the naming of Mass DPH campus at Jamaica Plain after Dr Al DeMaria, a living legend in public health and huge influence on my own path
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27 Sep 2025
More evidence for opioid antagonism as a potential therapeutic intervention in Alzheimer’s spectrum disorders, this time at delta receptors
Naltrexone is a non selective opioid antagonist w established track record and worth a pilot trial
pubs.acs.org/doi/10.1021/acs…
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27 Sep 2025
Studied food deserts in fellowship, interesting to see this study extending food insecurity to cognitive outcomes
🥗 ➡️ đź§
@JAMANetworkOpen
jamanetwork.com/journals/jam…
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