Efficient base editing and development in human embryos without chromosomal alterations biorxiv.org/content/10.64898…

Excited to share our preprint, reviving @kristyredhorse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:

After 20 years, 58 generations and more than 30,000 cloning attempts, a team of researchers has hit the limit on the number of times a single mouse can be serially re-cloned go.nature.com/47hykPQ

Tam, T.T.K.K., Xu, S., Li, Y. et al. Amniogenesis in embryos and stem cell models. Nat Cell Biol (2026). doi.org/10.1038/s41556-026-0…

Modeling human embryo implantation in vitro: Cell cell.com/cell/fulltext/S0092…

Now online! Modeling human embryo implantation in vitro dlvr.it/TPzkPm

🚨 BIG NEWS: The era of in vitro human embryo implantation has arrived! 🧬 We have successfully modeled the earliest stages of pregnancy in the lab using a new 3D "organoid uterus" platform. Published today in @CellCellPress: doi.org/10.1016/j.cell.2025.…

Leverage on our human blastoid model we now establish a 3D in vitro model for studying human implantation and implantation failure: Cell cell.com/cell/fulltext/S0092… Congrats to all co-authors and collaborators, especially Hongmei Wang @CAS! So proud of my former trainees Leqian Yu and Yulei Wei who have made this finally happen in their own labs! This project started shortly after we published the first human blastoid model based on naive human pluripotent stem cells and it took several years of trial and errors with different strategies. I am happy to see now it has been successfully applied to study mechanisms underlying human implantation and implantation failure. More importantly our model helps screen FDA approved compounds that hold the potential to overcome repeated implantation failure.

Findings may move science closer to growing organs in other species: Newsroom - UT Southwestern, Dallas, Texas utsouthwestern.edu/newsroom/…

RNA innate immunity constitutes a barrier for interspecies chimerism: Cell cell.com/cell/fulltext/S0092…

Despite high cell numbers and long lifespans, large animals don’t have higher cancer rates: Peto’s paradox. Elephants carry extra copies of tumor suppressor genes, while whales enhance DNA repair mechanisms! Fascinating that nature found different solutions to the same problem

Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale go.nature.com/3Lzg1NH

I am honored to express my opinion on this new approach in fertility and reprogramming -exciting times ahead!

Finally .. incredible much awaited wok on deriving avian naive ESCs “Derivation of embryonic stem cells across avian species” nature.com/articles/s41587-0…

Scholarship, abstract and early registration deadlines: 1. Scholarship/Short Talk Abstract Deadline: October 21, 2025 (11:59pm MST) 2. Early Registration: December 18, 2025 (Save $200 – 11:59pm MST) 3. Poster Abstract Deadline: January 27, 2026 (11:59 MST)

Scientists have for the first time ever filmed a crucial step that leads to new human life – cracking open a 'black box' of early development. @ojosnegros_sam @IBECBarcelona sciencealert.com/world-first…

A time-lapse film offers a glimpse of a hidden milestone of human development: the moment when the newly formed embryo latches onto the uterine lining. Watch a human embryo implant itself — with brute force nature.com/articles/d41586-0…

Just mind-blowing in every way!

1/n Fun journey continues: Our new @CellStemCell paper out on how the Inherent & Dormant Plasticity of mouse naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". cell.com/cell-stem-cell/full…