Jonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members.
Joined October 2019
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Jonathan Weissman's Lab retweeted
📣 new preprint multimodal atlas. Imaging scRNA, 57M cells. 🧬🔬
Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std?
The answer surprised us 🧵
biorxiv.org/content/10.64898…
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Jonathan Weissman's Lab retweeted
May 30
What is the global structure of cell-state space—and how do perturbations drive transitions within it?
Excited to share our new preprint (biorxiv.org/content/10.64898…), a work in collaboration with @JswLab.
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Jonathan Weissman's Lab retweeted
May 9
A few years in the making in the @JswLab with @WilliamNColgan, Zack Smith, and the rest of our fantastic team: Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis. Excited to hear everyone's thoughts!
Excited to share a new preprint from the lab led by @LukeKoblan and @WilliamNColgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! biorxiv.org/content/10.64898…
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Excited to share a new preprint from the lab led by @LukeKoblan and @WilliamNColgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! biorxiv.org/content/10.64898…
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This has been a wonderful collaboration between our group and Zachary Smith’s Group @yalemed and the Max Planck Institute with important contributions from @nir_yosef1 @WeizmannScience, @ZhuangLab @HarvardCCB, and Kyle Loh @Stanford
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The scale and density of this dataset provide a framework for quantifying cell fate restriction dynamics–the frequency, reproducibility, and variance of fate decisions across embryos–and enabling a unified view of embryogenesis to uncover core principles of mouse development
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There is plenty more in the manuscript so please give it a read, we are excited to hear feedback from the community. Stay tuned for exciting next steps!
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