Xiaowei Zhuang's Lab at Harvard University and Howard Hughes Medical Institute
Joined November 2024
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1 Photos and videos
May 30
What is the global structure of cell-state space—and how do perturbations drive transitions within it?
Excited to share our new preprint (biorxiv.org/content/10.64898…), a work in collaboration with @JswLab.
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May 30
Moreover, we perform a genome-scale Perturb-seq screen in human embryonic stem cells, validating and extending these findings and uncovering a class of mesenchymal transitions induced by diverse perturbations to cellular stress-response pathways.
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May 30
Explore the Global Pattern Browser: xingjiepan.github.io/SCMG/
Code: github.com/xingjiepan/SCMG
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25 Nov 2024
Delighted to share this preprint from Prof. Rong Fan Lab @RongFan8 and Prof. Sidi Chen lab @sidichen on Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT. Congatulations, Alev, Xiaolong, Feifei, Paul, Sidi and Rong!
Thrilled to share Perturb-DBiT — spatial unbiased in vivo perturb-seq with genome-scale CRISPR libraries! Hope you enjoy reading it over the Thanksgiving week 🥰 Kudos to @AlevBaysoy, Xiaolong, Feifei, and Paul. & collaboration with @sidichen, Hongbo Chi.
biorxiv.org/content/10.1101/…
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25 Nov 2024
Check out our preprint on Perturb-multi (doi.org/10.1101/2024.11.18.6…), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.
21 Nov 2024
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
biorxiv.org/content/10.1101/…
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