Group leader at the University of Helsinki. Antibiotic resistance, metagenomics, bioinformatics, and big data.

Joined February 2016
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🚨 Our new study on 14,641 gut metagenomes: 🧬 Women have 9% more antibiotic resistance genes (ARGs) than men 🌍 Difference not observed in LMICs 🧑 ARG differences appear in adulthood 📖 rdcu.be/emLQg #AMR #GenderHealth #Microbiome #GlobalHealth

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Using wastewater surveillance to investigate community-level differences in antibacterial resistance in a major urban center, USA | Applied and Environmental Microbiology journals-asm-org.ezproxy.utu…

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Our article in @NatureComms released in July! What socio-demographic, #microbiome, and health variables associate with higher #AMR? 1) Being a woman & high-income class 2) Poultry and salad 3) #Antibiotic use is most important Read the full article here: rdcu.be/eBRPB

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Big thanks to the FINRISK cohort participants and all the collaborators and co-authors!
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Dr. Katariina Pärnänen retweeted
✨ Job Alert: Bioinformatician & Data Manager ✨ Support our research on milk, microbiomes & child health! 📍Remote (within 🇨🇦) or In-person 💵 $74K–$107K benefits ⏱️ Full Time 🎓 MSc & 4 yrs experience req'd Apply at: umanitoba.ca/careers/ (#38485) Pls share! 🙏🏻
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9/9 Take home message! Recognizing gender and age-specific differences in AMR is essential for research and for creating fair healthcare strategies. For more details, data, and code, read the full study here: nature.com/articles/s41522-0…
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8/9 Age and geography were significant factors associated with resistome composition, with infants and the elderly showing higher ARG loads and diversity. This pattern underscores the impact of life stages on AMR. nature.com/articles/s41522-0…
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7/9 Genders share similar ARGs despite the difference in their abundance. Region and age explained far more variation in ARG composition than gender. nature.com/articles/s41522-0…
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6/9 Gender differences in ARG abundance emerged in adulthood, indicating that gender-associated lifestyle, biological, or healthcare-related factors in adulthood may be linked to antibiotic resistance. nature.com/articles/s41522-0…
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5/9 In LMICs, limited data indicated that when accounting for confounding factors such as age and socio-economics, the difference between men and women was not significant. nature.com/articles/s41522-0…
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4/9 Women in HICs also showed slightly higher ARG diversity than men, suggesting a broader range of resistance genes present in their gut microbiome. nature.com/articles/s41522-0…

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3/9 In high-income countries (HICs), women had 9% higher ARG abundance compared to men. This suggests that women in HICs may be more exposed to or carry more antibiotic-resistant bacteria. In low-income countries (LMICs), the trend was reversed. nature.com/articles/s41522-0…
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2/9 Antimicrobial resistance #AMR is a major #globalhealth threat. How does it vary between genders? We analyzed 14,641 open human gut #metagenomes from 32 countries to investigate gender differences in #antibioticResistance genes (ARGs). nature.com/articles/s41522-0…
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1/9 Did you know that the female #microbiome is unique in many ways, and antibiotic resistance in the gut microbiome varies between genders? See npj Biofilms and Microbiomes special issue, Women and their microbes, to learn more! nature.com/collections/djgii…
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🚨 Our new study on 14,641 gut metagenomes: 🧬 Women have 9% more antibiotic resistance genes (ARGs) than men 🌍 Difference not observed in LMICs 🧑 ARG differences appear in adulthood 📖 rdcu.be/emLQg #AMR #GenderHealth #Microbiome #GlobalHealth

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Dr. Katariina Pärnänen retweeted
New paper out @Nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming testosterone treatment in trans-men assigned female sex at birth: nature.com/articles/s41586-0…
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