Kelly Chibale (@Kelly_Chibale)

25 Jul 2022

1/2 #Afropessimism – a term that I often use to emphasize a critical & often ignored issue. It is sad that people don’t trust African scientific #innovation. I always say this & I repeat – as Africans, we must take pride in what is #locallyproduced & support #localproducers.

ACS Publications Bio & Med Chem Content

Kelly Chibale retweeted

Jun 11

The June Issue of #ACSMedChemLett is out today! Sara Goldstein describes three must read articles this month In this Issue: go.acs.org/ejs

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Kelly Chibale

Jun 11

#ACSMedChemLett reports a greener, simpler way to make a new molecules that may fight bacteria. In early tests, bacteria did not develop resistance to one compound after many repeated exposures. @ACSBioMed pubs.acs.org/doi/10.1021/acs…

Eco-Friendly Access to Indenodiazepinones from o-Formylynones and o-Phenylenediamines and Their...

We have conceptualized and executed an efficient, eco-friendly, one-flask, synthetic approach to functionally enriched and potentially pharmacophoric tetracyclic indenodiazepinones through a base-m...

ACS Publications Bio & Med Chem Content

Kelly Chibale retweeted

BLANCO-MEDI @MJBlanco_medi

Jun 4

📢 Call for Abstracts: ACS150 JACS Symposium Series: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa! 📍 @UCT_news 📅 10-11 September Submit your abstract before 10 June 2026.  🔗 Apply today:  go.acs.org/eh5

Poster abstract submissions for the ACS150 JACS Symposium: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa are now open!  

📍University of Cape Town, South Africa
📅 10-11 September 2026

We are seeking abstracts that are focused on the following topics:

Drug Discovery & Therapeutics
Infectious Diseases & Resistance
Non-Communicable Diseases
Biomedical Imaging & Diagnostics
Biomaterials Applications in Medicine
Chemical & Molecular Biology Methods
Natural Products Synthesis

To present at this scientific exchange on biological and medicinal chemistry, apply to attend this free event and submit your poster abstract before 10 June 2026.

ALT Poster abstract submissions for the ACS150 JACS Symposium: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa are now open!   📍University of Cape Town, South Africa 📅 10-11 September 2026 We are seeking abstracts that are focused on the following topics: Drug Discovery & Therapeutics Infectious Diseases & Resistance Non-Communicable Diseases Biomedical Imaging & Diagnostics Biomaterials Applications in Medicine Chemical & Molecular Biology Methods Natural Products Synthesis To present at this scientific exchange on biological and medicinal chemistry, apply to attend this free event and submit your poster abstract before 10 June 2026. 

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BLANCO-MEDI

Kelly Chibale retweeted

Jun 3

Announcing Call for Papers for Special Issue on Allosteric Modulators in Drug Discovery. pubs.acs.org/doi/10.1021/acs…

ACS Publications Bio & Med Chem Content

Kelly Chibale retweeted

May 31

Don't forget to register for our upcoming webinar, where winners of the 2026 Portoghese Lectureship Award will be discussing 'Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’. 📅 June 3, 12:00PM EDT Register to attend: go.acs.org/eg0

Announcing ‘Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’, part of our ‘Fueling Scientific Discovery: ACS Publications’ Celebrated Scientists’ webinar series.

Taking place on June 3, 12:00–13:30 ET - and presented by our 2026 Portoghese Lectureship Award winners:

🌟 Prof. Alison Axtman, UNC Chapel Hill, United States
🌟 Prof. Fleur Ferguson, UC San Diego, United States

Moderated by: Prof. Craig Lindsley, Editor-in-Chief, Journal of Medicinal Chemistry and Professor at Vanderbilt University, United States

ALT Announcing ‘Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’, part of our ‘Fueling Scientific Discovery: ACS Publications’ Celebrated Scientists’ webinar series. Taking place on June 3, 12:00–13:30 ET - and presented by our 2026 Portoghese Lectureship Award winners: 🌟 Prof. Alison Axtman, UNC Chapel Hill, United States 🌟 Prof. Fleur Ferguson, UC San Diego, United States Moderated by: Prof. Craig Lindsley, Editor-in-Chief, Journal of Medicinal Chemistry and Professor at Vanderbilt University, United States

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ACS Publications Bio & Med Chem Content

Kelly Chibale retweeted

May 30

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Kelly Chibale

May 26

My latest essay reflects on how AI can strengthen African drug discovery and development ecosystems, from research and clinical trials to scientific capacity and locally relevant innovation. amacad.org/publication/daeda… #KellyChibale #AI #DrugDiscovery #AfricaScience #GlobalHealth

The Role of AI in Drug Discovery in Africa

The proliferation of artificial intelligence presents Africa’s drug discovery landscape with a transformative opportunity to accelerate research and development (R&D) to address the continent’s heavy...

amacad.org

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Kelly Chibale

May 25

On #AfricaDay, I reflect on how surviving malaria as a child in Zambia shaped my life’s work in science and drug discovery. Read more: linkedin.com/posts/kelly-chi… #KellyChibale #AfricaScience #GlobalHealth #MalariaResearch

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Kelly Chibale

May 25

It also reminded me that behind every medicine are years of research, collaboration, investment and volunteers who participate in clinical trials for the benefit of others.

Kelly Chibale

May 20

Scientists are designing smarter cancer drugs that target tumour cells while sparing healthy ones. A new class of molecules developed by Ipatova et al. showed activity against breast cancer cells with less harm to normal cells: pubs.acs.org/doi/10.1021/acs… @ACSPublications

Spirocyclohexane-Chroman-4-one Derivatives as Selectively Cytotoxic Agents in Breast Cancer Models

The design of novel small molecules with high selectivity for anticancer action remains a priority in the development of chemotherapy. A combination of the “privileged scaffold” of the chroman-4-one...

Kelly Chibale

May 13

Researchers have discovered a promising new way to treat pain without opioids. By targeting a specific “pain signal” channel (NaV1.8), Dialer et al. developed compounds that are more selective, longer-lasting and potentially safer: pubs.acs.org/doi/10.1021/acs… @ACSPublications

Discovery and Optimization of Potent and Subtype-Selective Urea-Derived NaV1.8 Inhibitors

Inhibitors of voltage-gated sodium channel 1.8 (NaV1.8) are anticipated to provide opioid-free treatment for acute pain and potentially chronic neuropathic pain. Herein, we report on the discovery of...

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Kelly Chibale

May 6

Scientists are getting a clearer picture of how diabetes and weight-loss drugs work. By watching receptors on cells in real time, they found that drugs “grab on” in two ways, helping to explain why some treatments work better than others: pubs.acs.org/doi/10.1021/acs… @ACSPublications

In Vitro Characterization of Agonist and Antagonist Peptide Binding Interaction Kinetics to GLP-1R...

The glucagon peptide 1 receptor (GLP-1R), a class-B-type G protein-coupled receptor (GPCR), is a key therapeutic target for many metabolic disorders, including obesity and type 2 diabetes, due to its...

National Academy of Sciences @theNASciences

National Academy of Sciences

Kelly Chibale retweeted

Apr 25

Congratulations Kelly Chibale of @UCT_news, newly inducted NAS international member! #NAS163 #NASmember #chemistry #biology #pharmacology

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Kelly Chibale

Mar 31

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway pubs.acs.org/doi/10.1021/acs… @ACSPublications #KellyChibale #AntibioticDiscovery #DrugDiscovery #MedicinalChemistry #AntimicrobialResistance #InfectiousDiseases #GlobalHealth

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway

To tackle the emerging resistance against existing antibiotics, we screened natural-product (NP) libraries against two underexploited target enzymes from the 2C-methyl-d-erythritol 4-phosphate (MEP)...

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Kelly Chibale

Mar 26

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid) #DrugDevelopment #MedicinalChemistry #DrugDesign #ProdrugStrategy #InflammationResearch #Immunology #Resatorvid #Pharmacokinetics #DrugRelease #ChemicalBiology

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Kelly Chibale

Mar 24

Discovery of a Colon-Targeted Prodrug as an Escherichia coli Biofilm Inhibitor for Treating Inflammatory Bowel Disease pubs.acs.org/doi/10.1021/acs… @ACSPublications #MedicinalChemistry #DrugDiscovery #ProdrugDesign #IBDResearch #InflammatoryBowelDisease #MicrobiomeScience #Biofilms

Discovery of a Colon-Targeted Prodrug As an Escherichia coli Biofilm Inhibitor for Treating...

We hypothesized that the formation of biofilms contributes to the onset of inflammatory bowel disease and, thus, attempted to develop biofilm inhibitors as potential treatment options. We identified...

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Kelly Chibale

Feb 26

Isoindolines and Isoindoline-1,3-diones as Nonpeptide ACE Inhibitors: An In Silico and In Vitro Modeling Approach pubs.acs.org/doi/10.1021/acs… @ACSBioMed #KellyChibale #MedicinalChemistry #Hypertension #CardiovascularResearch #ACEInhibitors #DrugDiscovery #ComputationalChemistry

Isoindolines and Isoindoline-1,3-diones as Nonpeptide ACE Inhibitors: An In Silico and In Vitro...

Hypertension, a major cardiovascular risk factor, is often treated with peptide-derived angiotensin-converting enzyme inhibitors (ACEi), which can have several side effects. This study examined a new...

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Kelly Chibale

Feb 24

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity pubs.acs.org/doi/10.1021/acs… @ACSBioMed #KellyChibale #MedicinalChemistry #CancerResearch #MitochondrialBiology #OncologyResearch #DrugDiscovery

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitoch...

Niclosamide, an FDA-approved anthelmintic, functions as a mitochondrial uncoupler with promising anticancer potential, yet its efficacy remains limited, often ascribed to poor bioavailability. We...

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Kelly Chibale

Feb 17

Maltose-Conjugated Thiosemicarbazones from Substituted Benzaldehydes: Synthesis and Inhibitory Activity against Gram-( ) and Gram-(−) Bacteria pubs.acs.org/doi/10.1021/acs… @ACSBioMed #KellyChibale #AntimicrobialResistance #AntibioticDiscovery #InfectiousDiseases #DrugDiscovery

Maltose-Conjugated Thiosemicarbazones from Substituted Benzaldehydes: Synthesis and Inhibitory...

The increasing prevalence of multidrug-resistant bacteria necessitates the development of new antibacterial scaffolds with improved efficacy and safety. Thiosemicarbazones are known for their diverse...

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Kelly Chibale