We are studying the heterogeneity, origins and in-vivo tissue specific functions of murine mononuclear phagocytes in health and disease.
Joined May 2019
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Apr 30
We are excited to share our new publication in the @JExpMed . Dr. Jiseon Kim, who has been conducting over the past four years, led this study in collaboration with @jkyeom. I would like to sincerely thank Jiseon and co-authors for their contributions.
New study from Jiseon Kim, Jinki Yeom, Ki-Wook Kim et al. found that mesenteric #macrophage-#monocyte interactions control the magnitude of gut-mesentery #inflammation and its progression to systemic infection following enteric pathogen infection. hubs.la/Q04dSgBH0
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Apr 30
We are excited to share our new publication in the @JExpMed . Dr. Jiseon Kim, who has been conducting over the past four years, led this study in collaboration with @jkyeom. I would like to sincerely thank Jiseon and co-authors for their contributions.
New study from Jiseon Kim, Jinki Yeom, Ki-Wook Kim et al. found that mesenteric #macrophage-#monocyte interactions control the magnitude of gut-mesentery #inflammation and its progression to systemic infection following enteric pathogen infection. hubs.la/Q04dSgBH0
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Apr 30
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6. Il1r1 ko and anti-IL-1R Ab treatment improve survival following STm infection, indicating the dysregulated IL-1b signaling from activated monocytes drives increased mortality.
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5. Depletion of mesentery-resident macrophages accelerates mortality and exacebates systemic STm infection, accompanied by excessive recruitment of activated monocytes with hightened expression of inflammatory cytokines.
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4. During STm infection, activated monocytes are sustantially recruited to mesentery. Although monocytes serve as major cellular sources of inflammatory cytokines, they are not involved in neutrohil efferocytosis.
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3. During STm infection, mesentery-resident macrophages become activated, and monocyte-derived MFs (Mo-MFs) and neutrophils are recruited to mesentery prior to systemic dissemination of STm. Excessively recruited neutrophils are cleared by CX3CR1 MFs, but not by other MFs.
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2. Using Ccr2ko, Cx3cr1- and Ms4a3-mediated fate mapping models, we demonstrated LYVE1hi TIM4(-) and LYVE1lo/- CX3CR1 MFs are replenished by GMP-derived monocytes, whereas LYVE1hi TIM4( ) MFs originate from CX3CR1 embryonic precursors.
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1. We indentified three distinct mesentery-resident MFs: LYVE1hi TIM4( ), LYVE1hi TIM4(-), and LYVE1lo/- CX3CR1 populations. Notably, MHC II epxression in CX3CR1 and LYVE1hi TIM4(-) MFs was reduced under GF condition, implying they are influenced by commensal-derived signals.
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Ki-Wook Kim Lab retweeted
Apr 29
During enteric bacterial infection, mesentery-resident macrophages act as a regulatory hub that controls the recruitment of inflammatory monocytes with elevated pro-inflammatory cytokine expression @JExpMed @KiwookKimLab @uiccom 🇺🇸🇰🇷
rupress.org/jem/article/223/…
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Ki-Wook Kim Lab retweeted
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K T cells: Immunity cell.com/immunity/fulltext/S…
Excited to present Nancy's postoctoral work @ucsfaging @immunox defining the role of aging fibroblasts in driving inflammaging.
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Macrophage Efferocytosis in Heart | Arteriosclerosis, Thrombosis, and Vascular Biology ahajournals.org/doi/10.1161/…
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Ki-Wook Kim Lab retweeted
Mar 23
Excited to share- Building on our work defining TRMacs heterogeneity, we show that distinct chemokine IM subsets and recruited TAM niches shape pro- and anti-tumor immunity within to the TME, while Ag moDCs trafficking to LNs dampen DC-based neoAg vac
nature.com/articles/s41590-0…
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🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴
sciencedirect.com/science/ar…
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It was my first time @AAAAI_org , which was fantastic meeting in learning microbiome-allergen axis. Thank you, Igor Broadsky and Beatriz Leon, for your wonderful monocyte and macrophage talks!
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Ki-Wook Kim Lab retweeted
Feb 26
Online now: Immunity in Alzheimer’s disease: From mechanisms to therapies dlvr.it/TR9xxM
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Feb 26
Online now: MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species dlvr.it/TRB67C
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Ki-Wook Kim Lab retweeted
Nishada Ramphal, Ari Waisman et al. reveal that NIK drives neuroantigen-specific T cell priming by regulating antigen presentation and IL-23 production, identifying NIK as a key orchestrator of #myeloid-driven CNS #autoimmunity. hubs.la/Q0451jT60
#Neuroinflammation
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Ki-Wook Kim Lab retweeted
Feb 20
"Why do females experience longer-lasting pain?"
After five years of Ph.D. work, it is finally out in @SciImmunology !
Huge thanks to @GeoffroyLaumet for the mentorship and guidance!
science.org/doi/10.1126/scii…
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It is an excellent review that covers the most recent findings and knowledge on serous cavities and the mesothelium. Thank you, @LucyHJackson_J
A new Science #Immunology Review examines how the serous cavities generate immune responses and resolves inflammation, highlighting the impact of crosstalk between organs and these spaces in health and disease. @LucyHJackson_J
scim.ag/4a1PgeU
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Ki-Wook Kim Lab retweeted
29 Dec 2025
Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF
nature.com/articles/s41590-0… @NatImmunol @UZH_ch
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