@UWBiochemistry. Ubiquitin and small heat-shock proteins. Biochemistry and biophysics. Student-run account. Email Rachel with inquiries.
Joined August 2021
- Tweets 30
- Following 108
- Followers 404
- Likes 57
Photos and videos
Pinned Tweet
21 Sep 2021
Please RT. Join the Kleviteers! Exciting post-doctoral opportunities available now. Uncover the mysteries of small heat shock proteins. Do a deep dive into protein ubiquitylation. Check us out at klevitlab.org/.
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Klevit Lab retweeted
4 Oct 2023
Really happy to share our paper out today @ Molecular Cell, where we elucidate the pivotal roles of BRCA1-BARD1 ligase in not only early DNA end resection but also subsequent stages in homology-directed repair. Congratulations to all the authors!
sciencedirect.com/science/ar…
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20 Oct 2023
Grad School Updates: Natalie Stone pursues a PhD at University of Washington -
#gradschool #research wix.to/RuDOs68
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20 Oct 2023
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13 Jun 2023
The final version of our work highlighting the role of BARD1 in BRCA1/BARD1-mediated chromatin recognition and modification is out now @embojournal
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Klevit Lab retweeted
31 Oct 2022
I'm a bit behind on posting this (as I just finished moving transatlantic) but my second PhD paper is finally published! @NatureComms
nature.com/articles/s41467-0…
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Klevit Lab retweeted
13 Sep 2022
The Preview ‘HHARI in motion reveals an unexpected substrate recognition site for RBR ligases’ from Ben Stieglitz @QMUL
doi.org/10.1016/j.str.2022.0…
highlights the recent Structure paper from @KlevitLab @UWBiochemistry:
doi.org/10.1016/j.str.2022.0…
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Klevit Lab retweeted
15 Aug 2022
Super excited for Chris Woods to defend his dissertation (working with @KlevitLab) gonna be 🔥🔥
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17 Jun 2022
We are thrilled to share our work on Cullin-independent substrate recognition by the RBR E3 ligase HHARI, led by @KHReiter now out in @Structure_CP. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic.
authors.elsevier.com/a/1fG9j…
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17 Jun 2022
HDX-MS, XL-MS, and NMR studies reveal that HHARI is released from auto-inhibition by a phosphomimetic mutation, and that the Rcat domain contains a substrate-binding surface.
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17 Jun 2022
A wonderful collaborative effort with the labs of Mike Guttman, Trisha Davis, and Mike MacCoss.
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Klevit Lab retweeted
12 Jun 2022
There is a story that I have been wanting to tell for a while regarding a scientific journey that started more than 6 years ago. It’s been a really eye-opening process and I hope it can serve as an inspiration to others, especially those starting their research careers.
A 🧵...
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Klevit Lab retweeted
13 Jun 2022
Really excited (and a little jealous) that @tylergfranklin is spending the week up in the @KlevitLab at @UWBiochemistry. Can’t wait to see what kind of data he comes home with. I wonder if my old lab bench is available…
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Klevit Lab retweeted
12 May 2022
I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. biorxiv.org/content/10.1101/…
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14 Apr 2022
Exciting new preprint from past lab member @HannahEBaughman
13 Apr 2022
We posted a manuscript of my postdoc research on bioRxiv yesterday. We characterize the transcription activation domain of RelA and found that it enhances the binding affinity of the p50/RelA heterodimer for DNA, especially for sequences that don't match the κB consensus motif.
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Klevit Lab retweeted
29 Mar 2022
1/4 Join us at this year's @FASEBorg summer conference "The Ubiquitin and Ub-like Proteins Conference: Cell Functions and Therapeutic Targeting" July 24-28 in Southbridge, MA.
faseb.org/meetings-and-event…
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26 Mar 2022
Check out our new review highlighting recent structural and cellular insights into BRCA1/BARD1 recognition and activity at nucleosomes!
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26 Mar 2022
We're looking for a post-doc to join our BRCA1/BARD1 team. Lots of exciting science to be done. Contact Rachel @ klevit@uw.edu.
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