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Institute of Molecular Immunology @KnolleLab

#HBV #Tcells #tissueimmunity #antiviral #anticancer #immuneregulation #immunotherapy #preclinicalmodels #clinicaltranslation #imagingmassspec

Joined April 2022
  • Tweets 254
  • Following 347
  • Followers 449
19 Photos and videos
Institute of Molecular Immunology retweeted
WüSI - Systems Immunology Würzburg@Wue_SI
10 Apr 2025
A second priming phase promotes high-affinity CD8 T cells by coordinating CD4 help and the relay of IL-2 in subfollicular LN niches. Congrats to @Wue_SI’s Kasia, Deeksha, @Kamu_Lab @GeorgGasteiger . science.org/doi/10.1126/scie…

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals

T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their...

science.org
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Job alert in our Institute of Molecular Immunology! Two PhD positions in the field of immune regulation in autoimmune liver diseases. Both positions are embedded in the newly funded CRC1700 together with Hamburg. Please check our official job announcement for more information
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We are proud to host the GASL Annual Meeting 2025 from 14-15 February in Munich. The GASL program with fanatastic talks and poster is out now! Here you can find it👇
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We are proud to announce that the SFB 1700 Initiative "Immunregulation in der Leber: von Homöostase zur Krankheit" in which we will be part of will be funded for the next four years!🥳 Exciting opportunitiy to unravel immune-mediated mechanisms of autoimmune liver diseases!
DFG public | @dfg_public@wisskomm.social@dfg_public
25 Nov 2024
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️dfg.de/de/service/presse/pre…
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We are excited that our study on the liver immune rheostat regulating CD8 T cell immunity in chronic HBV infection is published!🥳 @nature (nature.com/articles/s41586-0…)

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Nature - A liver-intrinsic mechanism is presented that suppresses effective anti-hepatitis virus B responses in mice and humans by rendering virus-specific CD8 T cells refractory to activation...

nature.com
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🔎HBV-specific CD8 T cells are in close & prolonged contact with liver sinusoidal endothelial cells when recognizing their antigen on hepatocytes. We termed this close & prolonged contact an immune rheostat, that increases cAMP-PKA signalling and hampers T cell effector functions
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Huge thanks to all of our collaborationpartners for their contributions and continuos help! @ProtzerLab @JBoettcherLab @maini_lab @LauerLab @LabOxenius
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Huge thanks to all of our collaborationpartners for their contributions and continuos help! @ProtzerLab @JBoettcherLab @maini_lab @LauerLab @LabOxenius
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Institute of Molecular Immunology retweeted
Cell@CellCellPress
18 Jun 2024
Now online! Therapeutic potential of co-signaling receptor modulation in hepatitis B dlvr.it/T8SXy2

Therapeutic potential of co-signaling receptor modulation in hepatitis B

In this study, we traced the trajectory and fate of dysfunctional HBV-specific CD8 T cells and analyzed the modulation of co-signaling receptors following hepatocellular priming. We identified 4-1BB...

cell.com
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Institute of Molecular Immunology retweeted
Waggoner Lab@LabWaggoner
14 Jun 2024
A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity @SciImmunology science.org/doi/10.1126/scii…

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity.

science.org
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Institute of Molecular Immunology retweeted
Waggoner Lab@LabWaggoner
14 Jun 2024
NK cells undergo tissue redistribution during fasting, where the spleen and bone marrow microenvironments metabolically reprogram and prime NK cells to increase anti-tumor function @ScientistBecs @SunLab_Official @ImmunityCP cell.com/immunity/abstract/S…

Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity

Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...

cell.com
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Shape of naive T cells shapes the immune response. Pretty cool findings! ://www.science.org/doi/10.1126/science.adh8967
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Institute of Molecular Immunology retweeted
Mirco J. Friedrich@mircoscopy
3 May 2024
Excited to share our latest publication in @SciImmunology! We've uncovered an NK cell-mediated immune checkpoint (B7H6 : NKp30) that limits CAR T cell persistence, revealing new insights into immune regulation. #Immunology @broadinstitute @DKFZ science.org/doi/10.1126/scii…
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This is a very impressive study just published in @Nature about the molecular and cellular mechanisms of liver regeneration after injury! There are migrating heptocytes😵 nature.com/articles/s41586-0…

Multimodal decoding of human liver regeneration

Nature - Harnessing single-nucleus RNA sequencing and spatial profiling, this work dissects unanticipated aspects of human liver regeneration to uncover a novel migratory hepatocyte subpopulation...

nature.com
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Fantastic story from in-house research group @JBoettcherLab out today in @Nature! PGE2 impair the differentiation of stem-like CD8 T cells into effector CD8 T cells locally in the tumor. A very important study for the development of effective anti-cancer immunotherapy
Jan Böttcher@JBoettcherLab
24 Apr 2024
We are thrilled that our study on PGE2-mediated impairment of TCF1 stem-like CD8 T cell responses in cancer, with (twitterless) Sebastian Lacher as first author, is now published @Nature! 👇 a short 🧵 below! nature.com/articles/s41586-0…
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Institute of Molecular Immunology retweeted
The Binder Lab@TheBinderLab
15 Apr 2024
Please check out this exciting symposium @dkfz @DKFZImmunology coming up June 5 and 6! Fantastic international speakers on #immunology, #virology and #cancer! Ask you students if they are interested– deadline for poster abstracts is April 30!
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Extensive and diverse fitness program for T cells to uncover stengths and weaknesses of T cell effector functions cell.com/cancer-cell/fulltex…
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