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The Koirala Lab @KoiralaLab

RNA is a tremendously important yet mysterious biomolecule with diverse functions. Our lab at UMBC aims to dig deeper into the RNA structures and functions!

Joined April 2022
  • Tweets 153
  • Following 258
  • Followers 353
38 Photos and videos
Many congratulations Manju Ojha @Manju_Shree90 who successfully defended her PhD thesis today! The lab is proud of your achievements Dr. Ojha! Wish you all the best for your future endeavors! #PhD, #RNA, #UMBC, @UMBCChemistry
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Many congratulations to the lab members Bethel (graduate), Megan, Magdalen and Hardik (undergraduates) who received various annual awards from the college of natural and mathematical sciences (CNMS)! The lab is proud of you #UMBC, #CNMS, @UMBCChemistry, @UMBCBiology, @KoiralaLab
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Many congratulations to Hasan @hbnnbd who successfully defended his PhD thesis today! All the best for your future endeavors Dr. Banna! #RNA, #UMBC, @UMBCChemistry The lab is proud of your accomplishments!
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Talented undergraduates, Magdalen Ruth and Barathi Sivakumaran presented their posters in UMBC URCAD. Congratulations to their graduate student mentor, @hbnnbd for excellent mentorship. Way to go! #UMBC, #URCAD, @UMBCBiology, @UMBCChemistry, #RNA.
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The Koirala Lab retweeted
Hasan Al Banna@hbnnbd
Mar 25
Excited to share our most recent article on Picornaviral IRES. Here, we determined the crystal structure of Type I IRES RNA (domain V) and identified structural homology among eIF4G-binding domains of different IRES types. nature.com/articles/s41467-0… @KoiralaLab @KrishnaNaba @UMBC

Structures of the eIF4G-binding RNA domains among picornaviral IRES types are topologically...

Nature Communications - The structure of a type I viral IRES RNA that binds human eIF4G shares a common topology with related RNAs from type II and III IRESs, despite sequence variations, offering...

nature.com
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New paper alert! nature.com/articles/s41467-0… Congratulations to all contributors. #RNA @UMBCChemistry @UMBC. Stay tuned for more results from the lab on IRES structural biology.

Structures of the eIF4G-binding RNA domains among picornaviral IRES types are topologically...

Nature Communications - The structure of a type I viral IRES RNA that binds human eIF4G shares a common topology with related RNAs from type II and III IRESs, despite sequence variations, offering...

nature.com
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The Koirala Lab retweeted
Manju Ojha@Manju_Shree90
Mar 8
Pleased to present my research at #ASBMB2026. Had a great first day. Thank you Chemistry/Biochemistry Interface (CBI) program for funding the conference. @KoiralaLab @UMBCChemBiochem
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This is how we do science in our lab @UMBC, educating new generations and serving the community! Thanks to @KrishnaNaba, @hbnnbd, Bethel Beyene and Manju Ojha for mentioning! Sisters in science: How one UMBC lab kindled a family tradition of discovery umbc.edu/stories/sisters-in-…

Sisters In Science: How One UMBC Lab Kindled A Family Tradition Of Discovery - UMBC: University Of...

On the fourth floor of UMBC’s Meyerhoff Chemistry Building, where students are hard at work exploring the intricacies of RNA molecules that may hold the...

umbc.edu
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Proud moment…more excited than my own PhD…many congratulations to Naba @KrishnaNaba for completing his degree as the first PhD from the @KoiralaLab! All the best for your future endeavors!
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The Koirala Lab retweeted
Christopher Bohrer@cbohrer3141
26 Nov 2025
Thrilled to share our new preprint on bioRxiv: we show how chromosomal topological domains in E. coli repress transcription, modulate supercoiling sensitivity, and induce coupling between neighboring genes—establishing DNA topology as a potent regulator. biorxiv.org/content/10.1101/…

Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring...

Chromosomal topology and transcription are tightly coupled, yet the quantitative impact of topological constraints on transcription, supercoiling, and the potential coupling between neighboring genes...

biorxiv.org
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The Koirala Lab retweeted
Saurja DasGupta@SaurjaDasGupta
17 Nov 2025
I adapted the PopSci Writing tutorial I teach at @NotreDame into a virtual workshop series in collaboration with @ClubSciWri, funded by @ResearchAmerica. We’ve had 2 workshops so far — more to come! Revealing the second article from this workshop series: sciwri.club/archives/14387

Cancer And The Immune System: A Molecular Battleground

by Anuli Khairatkar Cancer is a universally feared condition, but what about it is so terrifying? The danger of cancer lies not just in its origins, but also in how it interacts within the body onc…

sciwri.club
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A nice review about roles of RNA structures in viral genome translation! Congratulations to Guangming, Bethel and Josh for their first review paper from the lab! #RNA, ⁦@UMBCChemistry⁩, ⁦⁦@UMBCChemBiochem⁩ mdpi.com/1999-4915/17/11/140…

Roles of RNA Structures in the Genome Translation of ( ) Sense RNA Viruses

Positive ( ) sense RNA viruses include many important pathogens that exploit noncanonical translation mechanisms to express their genomes within the host cells. Unlike DNA or negative (−) sense RNA...

mdpi.com
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The Koirala Lab retweeted
Naba Krishna Das@KrishnaNaba
23 Oct 2025
I'm excited to share that our paper has been published today in @NatureComms! I want to thank my coauthors (undergraduate and high school students), my advisor @KoiralaLab, and lab members for their contributions and support. To read: nature.com/articles/s41467-0…

Structural basis for 3C and 3CD recruitment by enteroviral genomes during negative-strand RNA...

Nature Communications - X-ray crystallographic analysis and in vitro binding assays show that two 3CD monomers bind to each cloverleaf RNA in CVB3 via 3C domains, providing mechanistic insights...

nature.com
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New paper alert @NatureComms, rdcu.be/eL29w! Fantastic teamwork by Naba (graduate), Alisha (undergraduate) and Reem (high-schooler)! This is how we do research at UMBC! #UMBC, #RNA, @UMBCChemBiochem, @UMBCChemistry. Congratulations and thanks to all involved.

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🌳🥪 Our annual lab picnic 2025 was a blast! Great food, great laughs, and the best company. #LabLife #ScienceAndFun
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The last day of our first graduate student (@KrishnaNaba, in dark blue) in the lab! Best wishes for your new career at NCI. We will miss you!
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The Koirala Lab retweeted
UMBC@UMBC
11 Aug 2025
At the 2025 UMBC Summer Undergraduate Research Fest (SURF), students presented and celebrated their summer's worth of research and applied learning experiences while contributing to UMBC's scholarly community. Three participants share their moments of joy throughout the process.
A man in a white shirt stands in front of a research poster. Quote text and the UMBC logo are visible. Transcribed Text: “My UMBC mentors did a great job helping me learn more about robotics and understand everything that goes into a research project. It was very cool getting to interact with all the robots in the lab!” – Henry Gardiner Summer REU Student

ALT A man in a white shirt stands in front of a research poster. Quote text and the UMBC logo are visible. Transcribed Text: “My UMBC mentors did a great job helping me learn more about robotics and understand everything that goes into a research project. It was very cool getting to interact with all the robots in the lab!” – Henry Gardiner Summer REU Student

Person smiling next to a research poster with a quote about research passion. Transcribed Text: "Working on this project with Dr. Leips has reinforced my passion for research. I'm so in love with what I'm doing. It's exciting to get to see a research project through to the end, even when the results are not what we expect." Christa Richardson Biochemistry & Molecular Biology

ALT Person smiling next to a research poster with a quote about research passion. Transcribed Text: "Working on this project with Dr. Leips has reinforced my passion for research. I'm so in love with what I'm doing. It's exciting to get to see a research project through to the end, even when the results are not what we expect." Christa Richardson Biochemistry & Molecular Biology

A woman in a geometric dress stands next to a scientific poster, with text and the UMBC logo on the left. Transcribed Text: “Working in the lab full time over the summer allowed me to see experiments from start to finish, and understand better how different parts of the lab’s research work together. I’m so grateful to Hasan Al Banna, my graduate student mentor, who has always been supportive.” Magdalen Ruth Biological Sciences

ALT A woman in a geometric dress stands next to a scientific poster, with text and the UMBC logo on the left. Transcribed Text: “Working in the lab full time over the summer allowed me to see experiments from start to finish, and understand better how different parts of the lab’s research work together. I’m so grateful to Hasan Al Banna, my graduate student mentor, who has always been supportive.” Magdalen Ruth Biological Sciences
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Undergraduate Magdalen Ruth presenting her research in UMBC’s SURF symposium! Koirala lab is proud of you, Magdalen! Way to go! Many thanks to her graduate student mentor Hasan @hbnnbd #umbc @UMBCChemistry @KoiralaLab #RNA
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The Koirala Lab retweeted
Manju Ojha@Manju_Shree90
7 Jul 2025
I am thrilled to share that our latest research article focusing on the structural plasticity of HIV-1 RRE has been published . I would like to thank my supervisor, co-authors and collaborators. @KoiralaLab academic.oup.com/nar/article…

Mutation-driven RRE stem-loop II conformational change induces HIV-1 nuclear export dysfunction

Abstract. The Rev response element (RRE) forms an oligomeric complex with the viral protein Rev to facilitate the nuclear export of intron-retaining viral

academic.oup.com
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Our lab in UMBC news! Awesome story about graduate-undergraduate collaboration and mentorship! UMBC’s Koirala Lab celebrates students’ award-winning RNA research and peer mentorship umbc.edu/stories/student-awa…

UMBC’s Koirala Lab Celebrates Students’ Award-winning RNA Research And Peer Mentorship - UMBC:...

A talented trio of students has earned accolades for their innovative work with Deepak Koirala, assistant professor of chemistry and biochemistry.

umbc.edu
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