Life sciences, structural biology, ribosome
Joined August 2020
- Tweets 332
- Following 189
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28 Photos and videos
Pinned Tweet
27 Aug 2020
All life depends on accurate translation (both intracellular & international). Using time-resolved cryo-EM, we watched ribosomes decode mRNA, aided by EF-Tu and GTP. See our animations & article (nature.com/articles/s41586-0…) on how ribosomes proofread tRNAs to make correct proteins:
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Korostelev Lab retweeted
10 Dec 2025
The Gonzalez Lab at Columbia University is seeking a scientific leader!
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
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7 Dec 2025
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome. GTPBP1 promotes more stringent mRNA decoding than the bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
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30 Nov 2025
Using "in extracto cryo-EM", we visualize ribosomes in mammalian lysates, including RRL. "Hibernating" ribosomes carry proteins that protect functional centers. These include elongation factor eEF2, LARP1 implicated in mTOR signaling, eIF5A etc. biorxiv.org/content/10.1101/…
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Korostelev Lab retweeted
14 Jul 2025
Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin @shuramankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… researchsquare.com/article/r…
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16 Jun 2025
ROOL monomers entangle with other monomers via strand swapping to form octameric nanocages.
nature.com/articles/s41586-0…
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16 Jun 2025
With our RTI colleagues Xiaobin Ling and @WenwenFang2, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of long-noncoding ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al!
nature.com/articles/s41586-0…
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16 Jun 2025
Activation of Retron-Septu for antiphage defense. Congrats @futianmin and all co-authors!
science.org/doi/full/10.1126…
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Korostelev Lab retweeted
7 May 2025
“Undermining the future of American science is not a path to accountability — it’s a path to decline.”
In a powerful new piece, my colleague Daphna Shohamy explains how canceled grants are driving young scientists out of science—and out of the country.
🔗 statnews.com/2025/05/07/us-s…
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Korostelev Lab retweeted
7 May 2025
In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs…academic.oup.com/nar/article…
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Korostelev Lab retweeted
15 Apr 2025
We developed a new siRNA drug candidate for prion disease, a @broadinstitute / @RTI_UMassChan collaboration. We now have an open IND meaning FDA has given us permission to start first-in-human trials. Work remains before trials can launch. The full update: cureffi.org/2025/04/14/open-…
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Korostelev Lab retweeted
15 Apr 2025
I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex.
jbc.org/article/S0021-9258(2…
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Korostelev Lab retweeted
8 Apr 2025
Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with @inada_lab and Zaher lab. Data collected at @DCI_EM.
PNAS pnas.org/doi/10.1073/pnas.24…
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Korostelev Lab retweeted
7 Apr 2025
Anastasia Khvorova, PhD, named 2025 Else Kröner Fresenius Prize for Medical Research awardee for her pioneering work in the field of RNA-based therapies: direc.to/nacN
#EKFprize25 #EKFS #ElseKrönerFreseniusStiftung #RNA #RNAtherapies @EKFStiftung @RTI_UMassChan
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Korostelev Lab retweeted
27 Feb 2025
Biological systems find ingenuous solutions. Almost anything that can happen, happens.
Still, I would not have guessed a role of RNA-binding proteins on the cell surface.
The Flynn lab are boldly investigating glycoRNAs and following their leads.
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Korostelev Lab retweeted
3 Feb 2025
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
cell.com/cell/fulltext/S0092…
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Korostelev Lab retweeted
24 Jan 2025
Our review on small endogenous RNAs in animals is online. We thank @MartinjSimard, @SvobodaLab and the third, anonymous, reviewer for helping us improve our manuscript. bit.ly/3Ebk931
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13 Jan 2025
Gabriel Demo and colleagues report how a small archaeal protein (aRDF) dimerizes 30S subunits to prevent ribosome formation:
academic.oup.com/nar/article…
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Korostelev Lab retweeted
7 Jan 2025
Using reporters with long unstructured 5’ UTRs, we examined which initiation factors are limiting for 40S scanning. Our results&literature led us to the model that 40S scans 5’ UTRs by one-dimensional diffusion rather than helicase-driven translocation. biorxiv.org/content/10.1101/…
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Korostelev Lab retweeted
17 Dec 2024
It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-fragmented mitoribosome from Apicomplexa, such as Plasmodium falciparum and Toxoplasma gondii, now out in @NatureComms
rdcu.be/d3R8C
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Korostelev Lab retweeted
11 Dec 2024
Our latest work is out in @Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s41586-0…
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