Ribosomes & Translation Regulation; Antibiotics & Resistance Mechanisms; Structural Biology & Cryo-EM; University of Hamburg.
Joined June 2018
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96 Photos and videos
Nature research paper: RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity
go.nature.com/49sFSzs
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Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria dlvr.it/TQFc7k
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Jan 7
If you're a senior researcher (i.e., associate professor or more senior), and you'd consider moving to the University of Toronto to take up a Canada Impact Research Chair (1 million/year in funding), email me. Discretion guaranteed.
Please share to help me spread the word!
21 Dec 2025
Canada is investing over $130 million to recruit top researchers from abroad, with up to 1 million/year in research funding.🚀
📢Also: 600 doctoral scholarships and 400 postdoctoral research awards!
Join us at UToronto: jobs.utoronto.ca/job/Toronto…
@UofT @VectorInst @TorontoSRI
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Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: pdb101.rcsb.org/motm/313
ALT OLE RNA from Clostridium botulinum (pdb_00009lcr) is shown in pink on the left. ROOL RNAs can form cages built from 6 (right, top, pdb_00009j6y) or 8 (right, bottom, pdb_00009mds) subunits.
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New Biochem Soc Trans review:
eIF3 as a modular, central regulator of translation.
Authored by @ide_nicholas and Colin Echeverría Aitken, this review integrates genetic, biochemical, and structural perspectives and highlights open mechanistic questions.
doi.org/10.1042/BST20253069
ALT eIF3 is a central player in translation initiation and has been implicated in events throughout translation.
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Slightly overdue article highlight!
In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue.
🧵⬇️
doi.org/10.1073/pnas.2509408…
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@EUjamrai's “Sketching Antimicrobial Resistance” campaign is an important reminder of the power of antibiotics. Global, multi-faceted action is needed to address AMR. @CARB_X is committed to accelerating innovative projects that target the most serious, resistant bacteria.
We are about to launch a new campaign! 🎨 30 illustrators. 30 countries. One shared story.
🖌️ Across Europe, artists have come together to transform science into art, giving shape, colour and emotion to one of the biggest health challenges of our time: #antimicrobialresistance.
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15 Dec 2025
A Method to Watch: Predicting RNA structures
nature.com/articles/s41592-0…
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14 Dec 2025
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination | Nature Methods nature.com/articles/s41592-0…
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9 Dec 2025
New online! EMProt improves structure determination from cryo-EM maps bit.ly/48PJafU
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7 Dec 2025
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome. GTPBP1 promotes more stringent mRNA decoding than the bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
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4 Dec 2025
Great collaboration with @CarpeRibosomam and @slavicaPD labs on using MPRAs to look into non-coding mutations.
Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes: Cell Reports Methods cell.com/cell-reports-method…
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3 Dec 2025
New online! Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation bit.ly/4iCO2JI
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4 Dec 2025
nature.com/articles/s41592-0…
Huge congrats to our collaborative team for their success achieving "Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale"
rdcu.be/eS2ps
An advance in experimental throughput and sensitivity that revealed unexpected results!
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3 Dec 2025
I'm working on this little ribosome game. You have to build a peptide as fast as you can. Prokaryotes can incorporate 20 amino acids per second. Currently, only the tRNAs work; the amino acids are next.
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1 Dec 2025
Many congratulations to @DrMartyTaylor and all the co-first authors for providing a structural understanding of how mTORC2 recognizes and phosphorylates the Akt/PKB kinase, its most famous substrate. Massive amounts of work and creativity were required to make this possible.
1 Dec 2025
How can the same "master regulatory" protein mTOR recognize different sets of targets to separate nutrient and growth factor signals?
Thrilled to share our new paper, in which we reveal how mTORC2 recognizes Akt.
🧵 on our new paper in Science:
science.org/doi/10.1126/scie…
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2 Dec 2025
It was a great experience to work with a wonderful team led by @ruchianand1975. 👏👏
@unescorcb @DBTIndia @rajesh_gokhale
1 Dec 2025
Excited to share our collaborative work on Erm-mediated Antibiotic Resistance. Kudos to @SombuddhaS, @raj_at_iitb! Thanks @ANRFIndia (National Cryo-EM Facility) @iitbombay, @India_Alliance @SMSDLab_IITB @BattyBoffin @prem_s_kaushal @lab_engel @NACB_IITB
science.org/doi/10.1126/scia…
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1 Dec 2025
Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome - PubMed pubmed.ncbi.nlm.nih.gov/4128…
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25 Nov 2025
Japanese researchers found a new type of archaea with the smallest known genome: 238k bases.
They live inside ocean-dwelling dinoflagellates as symbiotes. Their genome "encodes the barest minimum of proteins for its own replication." All other molecules are taken from the host.
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