Father | Assistant Professor @PurdueBiochem (RNA editing and regulation) | Postdoc & PhD @WUSTL | MS & BS @MissouriState | #firstgen #NewPI #NIHMOSAIC K99/R00

Joined January 2013
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I am absolutely thrilled to announce that I will be starting my own lab @PurdueBiochem @PUCancerCenter @Purdue in January 2023. The Cottrell Lab will study RNA editing and post-transcriptional regulation in cancer and normal physiology. 1/5
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Kyle Cottrell retweeted
28 Aug 2025
PACT suppresses PKR activation, thus preventing activation of the integrated stress response, NF-κB, and cell death. Dimerization and double-stranded #RNA binding by PACT is required for this function. bit.ly/4oC3Vm7 @KyleCottrell @PurdueBiochem @PUCancerInst
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This manuscript was accepted @RNAJournal and is online ahead of publication now! Congratulations to first author Addison Young and all the co-authors (for several this is their first publication). @PurdueBiochem @PUCancerInst. rnajournal.cshlp.org/content…

Just in time for #RNA25, the Cottrell Lab has posted our first independent preprint to bioRxiv. This is the first first-author publication from graduate student Addison Young and the first publication for the four undergraduate co-authors. biorxiv.org/content/10.1101/… 1/2
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This is my first research article as sole corresponding author and the first from the Cottrell lab. I'm very happy that it ended up at RNA. This is my first time publishing in RNA and this was by far my best review experience to date. Huge thanks to editor and reviewers!
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This evening, the newest Cottrell Lab graduate student, Cassandra Smoak, will be presenting poster 402. Over the last few months she has been evaluating a recently published ADAR1 inhibitor - ZYS-1. I'll let her tell you if it is a good inhibitor or not... #RNA25
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Just in time for #RNA25, the Cottrell Lab has posted our first independent preprint to bioRxiv. This is the first first-author publication from graduate student Addison Young and the first publication for the four undergraduate co-authors. biorxiv.org/content/10.1101/… 1/2
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Thanks to @PurdueBiochem @PUCancerInst and @NIMHD for support. Head over to Bluesky for a thread describing the work bsky.app/profile/kylecottrel…. 2/2

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I'm thinking of shifting careers. I figure a job as a truck lift-kit salesperson would be more in line with the interests of our society, or maybe a job in the iron lung industry. There's gonna be a lot of demand there soon.
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Yesterday, during my lecture on Roundup and Roundup resistance, I spent a few minutes talking about restriction enzymes. I described how the study of bacterial resistance to phage infection led to one of the most consequential molecular biology discoveries ever. 1/n
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that arouse from studying bacterial immune systems - CRISPR-Cas9. All of this to make the point that funding basic science is essential to advancing human health and our society. After the election, it's a good idea for us to remind our students of the importance of research. 4/n
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The things we are teaching them in class didn't materialize out of thin air. They were discovered thanks to the hard work of scientists, and that work in almost all cases was enabled by federal research funding. Especially funding for basic science. 5/n
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We are about to get a lot of analysis and punditry to explain the election results. Let me simplify it for everyone - it's sexism.
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Nerd thought, I think we are at the 'Great Filter'. I'm not sure we are going to make it past it at the rate we are going.
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How am I going to break this to my daughter? How do I explain that this despicable person is going to be president again? That a lot of people, especially men, could put aside his racism, misogyny, and fascism, and vote for him. Or did they vote for him because of those things?
WTF is wrong with men in this country?
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WTF is wrong with men in this country?
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Somehow, I've managed to teach today and run a PCR (gel and all). Is my phone nearly dead already? Yes. Have I done anything else productive? No
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Hmm, I wonder which color is for the reference gene?
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Hey Buzz, how is a Trump administration going to prioritize human spaceflight while cutting 2 trillion from the federal budget? To cut that much you have to cut all discretionary spending, including NASA. Last I checked rockets are expensive.
prnewswire.com/news-releases… A half-Century ago, it was an honor to serve my country in the effort to put a human being on the Moon. I am proud of what we accomplished then and I have dedicated my life to the pursuit of an enduring human presence in space – it is a calling that runs through every fiber of my being.    Over time, I have seen our government’s approach to space wax and wane. But under the first Trump Administration, I was impressed to see how human space exploration was elevated as a policy of high importance again. Under President Trump’s first term, America saw a revitalized interest in Space, and his Administration reignited national efforts to get back to the Moon, and push on to Mars. The Trump Administration also reinstituted the National Space Council, and our Nation’s defense was enhanced with the creation of the U.S. Space Force – increasingly important as space becomes a contested domain. At the same time, I have been enthused and excited by the great advancements in the private sector space economy, led by visionaries like @elonmusk.  These are concrete accomplishments that align with my concerns and America’s policy priorities.       America is facing serious and difficult challenges both at home and abroad.  The Presidency requires clarity in judgement, decisiveness, and calm under pressure that few have a natural ability to manage, or the life experience to successfully undertake. It is a job where decisions are made that routinely involve American lives – some urgently but not without thought. The job requires sober analysis of frightening scenarios, and the instinct to lead with resolve. From the skies over Korea in air-to-air combat to navigating, landing, and walking on the Moon, I appreciate this kind of pressure. I know what it is like to have to make these kinds of decisions, with firmness and follow-through.   In this election, we have a choice and we all have one vote. For some, the choice may not be easy – but in times of uncertainty real leaders are most needed – to guide and inspire a people, to push through the noise, recognize what really matters, and accomplish missions critical to all citizens. Most Americans rightly consider it an honor to cast their vote for a leader they believe will best serve the nation. For me, for the future of our country, to meet enormous challenges, and for the proven policy accomplishments above, I believe we are best served by voting for @realDonaldTrump. I wholeheartedly endorse him for President of the United States. Godspeed President Trump, and God Bless the United States of America.
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I have most of my lab working on one project so we can get it out soon. Today, we got scooped. Devastated.
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Recently, I keep thinking back to a great lecture during my ethics course as a first year graduate student (Bob Mercer gave the lecture for those @WashUdbbs, @washumedicine). He framed the importance of research ethics in the context of societies' view of scientists. 1/n
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I'm a straight white male. While my politcal views, profession, and the fact that I'm an atheist surely earns me the label of 'the enemy within'. I don't have nearly as much to fear as the less privileged. The poor, BIPOC, LGBTQIA people and all women will suffer terribly... 6/n
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under a second, less restricted, Trump regime. Vote for them! Vote so they can live without oppression and persecution. Say no to bigotry, yes to common decency and yes to science! Vote for Harris.
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