Assistant Professor of Cancer Biology @WeillCornell NIH K99/R00 Fellow @theNCI Chromatin & Epigenetics in Cancer.

Joined April 2009
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Thrilled to share we are @theNCI R00-funded. 🥳 Looking for computational biologists or bioinformaticians. 👩‍💻👨‍💻 We have many exciting projects on the role of chromatin remodelers in blood cancers. 🩸🦀 Please share/DM/email if relevant. Our latest story: cell.com/cancer-cell/abstrac…
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Fantastic @BloodCancerUtd SCOR meeting in Germany! Great to see everyone in person!
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Fantastic new method by @raimondi_ivan and @landau_lab 🙌 We had a chance to try it firsthand. Congrats to all the authors! 👏
Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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Absolutely spectacular lymphoma meeting in Germany! 🩸🔬 Thank you for including me in this amazing lineup! @chr_reinhardt 🙌
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🧬 💻 We're looking for a motivated postdoctoral associate in computational biology to join Barisic Lab at Weill Cornell Medicine and study chromatin remodeling and 3D genome organization. Please share and apply below: postdocs.weill.cornell.edu/o…

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Fantastic new story by @efapostolou29 lab! This should be everyone’s next journal club paper! 🤩 Congrats to all the authors! 🙌
Excited to share our new paper in @NatureGenet led by the incredible @6jinLee! We uncover how cohesin loss impairs postmitotic refolding of 3D chromatin topology with limited context-specific effects on gene activation—especially during differentiation. nature.com/articles/s41588-0…
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Darko Barisic retweeted
New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.
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Very excited to share our lab was awarded The Andrew McDonough B Foundation grant for our research on pediatric lymphoma. 🩸@BePositiveFdn We’re so grateful for this support and excited to get to work. 🔬 bepositive.org/
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Darko Barisic retweeted
19 Nov 2025
Last reminder: We’ll see you bright and early at 9:30 AM EST on the 25th to kick off #chromatin2025! Fantastic lineup of speakers with discussion to follow each talk. Don’t forget to register for this virtual meeting if you haven’t yet: bit.ly/chromatin-2025
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Darko Barisic retweeted
9 Sep 2025
Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes: biorxiv.org/content/10.1101/…
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Lab night out on Broadway! 🎭 A well-earned pause from experiments. 🧬 @SixBroadway
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Darko Barisic retweeted
I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces. biorxiv.org/content/10.1101/…
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Darko Barisic retweeted
3 Jul 2025
I am thrilled to share with the world a new preprint, spearheaded by the truly amazing Jose Reyes in partnership with @LoweLabMSKCC. Focused on the benign to malignant transition in PDAC, uncovering roles of plasticity, tissue remodeling and P53 -> biorxiv.org/content/10.1101/…
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Huge congratulations to my postdoc Jiali Yu 👏 who has been awarded a fellowship from the National Cancer Center. @NCC_Org She’ll be investigating how chromatin remodelers contribute to the onset and progression of blood cancers. So proud and excited for what’s ahead. 🚀
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Huge congrats to @LabMelnick on being appointed the Director of the Josep Carreras Leukemia Research Institute in Barcelona! 🙌 👏
We are pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Leukaemia Research Institute. Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases. Read the full release here: carrerasresearch.org/en/news…
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Darko Barisic retweeted
7 Mar 2025
I'm running the NYC half marathon on March 15 to keep raising funds for ALS research - please donate if you can! Thank you. secure.als-ny.org/goto/Chris…

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Darko Barisic retweeted
So what's happening with medical research in the US? This is the cumulative award count from the NIH for the year. Doesn't look so good. But it gets worse. 1/
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Absolutely fantastic work from magnificent @Yael_David__ lab! Incredible science and amazing out-of-the-box approach. Congrats to all the authors and highly recommend the read. 🙌
I am extremely proud to see our work about Hepatitis B now published in @CellCellPress. From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 cell.com/cell/fulltext/S0092…
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#ASH2024 Highly recommend this place for lunch. Also, highly recommend the company @jchellmuth ❤️
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