New paper is out in Brain, Behavior, and Immunity!! 🥳 "P2X4 Drives Sex-Specific neuroprotection in autoimmune neuroinflammation" doi.org/10.1016/j.bbi.2026.1… We found that the purinergic receptor P2X4 protects against neuroinflammation, but only in females. Why? 🧵👇

📢🧠 New preprint from our group available on @medrxivpreprint. In this longitudinal study in early untreated RRMS patients, circulating M-MDSCs were associated with immune regulatory dynamics and better relapse recovery. Congratulations to all authors! medrxiv.org/content/10.64898…

Following Bolaños & Magistretti’s October 2025 review on the neuron–astrocyte metabolic unit, the November 2025 Nature Metabolism review by Asimakidou, Pluchino, Silva and colleagues brings microglia–neuron interactions into the discussion. They are not examining the same cellular mechanism, what connects them is the broader move to place neuronal function within the cellular interactions that shape brain metabolism and brain function. The November review adds the neuroimmune dimension, linking microglial metabolism to cognition, ageing, and disease.

Can't wait for this fantastic Symposium!

Does brain aging always mean vessel loss? 🧠We found a surprising hypervascularization, driving cognitive decline & blood-brain barrier damage in aging. 👇🧵biorxiv.org/content/10.64898… Led by @MihailMuc

Take a look at our new article! We demonstrate that the Alzheimer´s disease gene Presenilin regulates tau pathology via the autophagy & proteasome pathways. Funded by @CienciaGob @AgEInves @CIBER_ISCIII #CIBERNED @_BrightFocus @INC_UAB link.springer.com/10.1186/s4…

Today I submitted my review of a manuscript for a journal, which I will not name, and then received the comments sent to authors. There were 7 reviewers!!! Have we lost all sense?

Turkish photographer Uğur Gallenkuş portrays two different worlds within a single image

What happens to the brain after focal myelin loss? Our new paper, published today in @Nature tries to answer this question: go.nature.com/3Qgd47r Details in the 🧵 (1/8)

Minisimposium on #ASD: genetics, molecular mechanisms, circuits and behaviour. Organized by @UPV/EHU and @AchucarroGlia. Join us!!! Speakers and details below.

Achucarro Glia School is backed!!! Please check the program. Excellent speakers. Great opportunity to learn on Glia!!! x.com/i/status/2028798604442…

A recent study found that mice with variants in autism-associated genes have difficulty flexibly updating their expectations, providing new insights into the neurobiology of autism: simonsfoundation.org/2025/10… #neuroscience #BrainAwarenessWeek #BrainWeek

Excited to be back again at Sfari meeting in NY. Excellent meeting, finding colleagues, new ideas, excited findings. Thanks to @SimonsFdn for organising and support

Myelin sheaths persist for weeks following axon degeneration | Science Advances science.org/doi/10.1126/scia…

Registrations and abstract submissions for #AstrocyteCafe2026 are now OPEN!!! Spread the word 🤩 We hope to see many of you on June 3-5 in Pamplona!!! Thanks @KernelScience, for our brand new website and for helping organize this conference! 👇👇👇👇 astrocytecafe.com/#/conferen…

Stay tuned for the 3rd edition of the Achucarro International Glia School #AIGS2026, organized by @AchucarroGlia and @upvehu at the @pie_upvehu in the magnificent Bay of Plentzia, just minutes from Bilbao. 🧠🔬 Registration opens in March!