8 Photos and videos
HalicLab retweeted
4 Dec 2025
nature.com/articles/s41592-0…
Huge congrats to our collaborative team for their success achieving "Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale"
rdcu.be/eS2ps
An advance in experimental throughput and sensitivity that revealed unexpected results!
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HalicLab retweeted
6 Nov 2025
Researchers have mapped 117 kinases capable of phosphorylating the RNA polymerase II tail, revealing modifications at previously disregarded positions beyond amino acids two and five. This discovery expands our understanding of gene transcription control. ow.ly/crFR50Xo1en
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HalicLab retweeted
18 May 2025
Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H
nature.com/articles/s41422-0…
@StJudeStructBio @StJudeResearch
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HalicLab retweeted
3 Apr 2025
Scientists used cryo-EM to capture 13 distinct structures of the chromatin remodeler SNF2H in action. This research provides a complete view of nucleosome sliding, a key process in gene regulation. ow.ly/mhv150VtUoH
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Our recent publication in Cell Research visualizes continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H.
nature.com/articles/s41422-0…
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HalicLab retweeted
Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: cell.com/cell/fulltext/S0092…
Explore this amazing resource here:
yslproteomics.shinyapps.io/t…
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In our latest work we visualize continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H.
biorxiv.org/content/10.1101/…
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HalicLab retweeted
15 Nov 2024
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms
Awesome collaboration with @sagarchittori .
@StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab
rdcu.be/d0h2G
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HalicLab retweeted
30 Oct 2024
A preprint from the lab led by graduate student Dana R Kennedy.
doi.org/10.1101/2024.10.25.6…
Over 20 years ago, the Eissenberg lab showed that phosphorylation of HP1 is important for its silencing function. Why? Key observations from our study in fission yeast:
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HalicLab retweeted
We have exciting news to share!
Abhay Kotecha (@abhaykot) is joining us as Senior Director of Technologies for Cryo-EM and Cryo-ET. We're thrilled to have him continue his great work in #CryoET, building on his innovation at @thermosciEMSpec.
Welcome to @stjuderesearch, Abhay!
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HalicLab retweeted
12 Oct 2024
Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms
Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs.
@StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab
rdcu.be/dWKpF
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HalicLab retweeted
Still hot off the press — @kellogg_liz and colleagues present the first structure of a Fanzor2!
Fanzors are eukaryotic RNA-guided DNA endonucleases. With the available Fanzor1 structures, the new work offers a comprehensive view of the family's evolution
nature.com/articles/s41594-0…
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HalicLab retweeted
1 Oct 2024
St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomedical research with 115 new roles. His work will help integrate vast datasets and improve patient care. #DataScience #BiomedicalResearch
ow.ly/gQbN50TAASu
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HalicLab retweeted
1 Oct 2024
Happy to share our latest work from the @kellogg_liz lab, in collaboration with the Protein Technologies Center at St. Jude, where we describe the structure of Fanzor2. Special thanks to my co-authors, Zuhaib Qayyum and Ajay Tanwar.
nature.com/articles/s41594-0…
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HalicLab retweeted
1 Oct 2024
Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/S0092…
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HalicLab retweeted
We are thrilled to welcome the incomparable Yiorgo Skiniotis and his lab!
Yiorgo will also lead the new Center of Excellence for Structural Cell Biology, to advance cryoET and other cutting-edge approaches @StJudeResearch, paving the way for new, exciting biological insights!
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HalicLab retweeted
9 Sep 2024
Building on the work of Richard and Chris, here is our latest work showcasing the potential of the 100 keV #Tundra microscope with the Ceta F and Falcon C. We achieved high-resolution structures for a variety of protein complexes🧵.🔬#100keV #CryoEM. Movie by @lingboyu
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